BRD-K45746021_CC-401_PC3_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

176 genes differentially expressed following the BRD-K45746021_CC-401_PC3_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADARB1 adenosine deaminase, RNA-specific, B1
ADGRA3 adhesion G protein-coupled receptor A3
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANKRD27 ankyrin repeat domain 27 (VPS9 domain)
AURKA aurora kinase A
AXL AXL receptor tyrosine kinase
CCND2 cyclin D2
CHIC2 cysteine-rich hydrophobic domain 2
COL9A3 collagen, type IX, alpha 3
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
DKC1 dyskeratosis congenita 1, dyskerin
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DUSP22 dual specificity phosphatase 22
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FBL fibrillarin
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GAS6 growth arrest-specific 6
HACD1 3-hydroxyacyl-CoA dehydratase 1
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1
HOMER1 homer scaffolding protein 1
HSPA8 heat shock 70kDa protein 8
JADE2 jade family PHD finger 2
JMJD6 jumonji domain containing 6
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT14 keratin 14, type I
LARP1 La ribonucleoprotein domain family, member 1
MAGEA12 melanoma antigen family A12
MAGEA6 melanoma antigen family A6
MALT1 MALT1 paracaspase
MFSD12 major facilitator superfamily domain containing 12
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
ODC1 ornithine decarboxylase 1
OXTR oxytocin receptor
PIEZO1 piezo-type mechanosensitive ion channel component 1
PLK1 polo-like kinase 1
PODXL podocalyxin-like
POSTN periostin, osteoblast specific factor
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SATB2 SATB homeobox 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
TEX10 testis expressed 10
TPM1 tropomyosin 1 (alpha)
UBE2S ubiquitin-conjugating enzyme E2S
WNT5B wingless-type MMTV integration site family, member 5B

decreased expression

Symbol Name
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ADAM28 ADAM metallopeptidase domain 28
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADM adrenomedullin
AGA aspartylglucosaminidase
AGR2 anterior gradient 2
AHR aryl hydrocarbon receptor
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ALDOC aldolase C, fructose-bisphosphate
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANXA10 annexin A10
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
C10ORF10 chromosome 10 open reading frame 10
C1QTNF3 C1q and tumor necrosis factor related protein 3
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNE2 cyclin E2
CCNG2 cyclin G2
CD24 CD24 molecule
CD58 CD58 molecule
CDK1 cyclin-dependent kinase 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CFH complement factor H
CFI complement factor I
CLEC2B C-type lectin domain family 2, member B
COL3A1 collagen, type III, alpha 1
COL6A1 collagen, type VI, alpha 1
CRIP1 cysteine-rich protein 1 (intestinal)
CSTA cystatin A (stefin A)
CYB5A cytochrome b5 type A (microsomal)
DLD dihydrolipoamide dehydrogenase
DPP4 dipeptidyl-peptidase 4
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
ECM2 extracellular matrix protein 2, female organ and adipocyte specific
EGLN3 egl-9 family hypoxia-inducible factor 3
EMP1 epithelial membrane protein 1
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
ETV1 ets variant 1
FAM134B family with sequence similarity 134, member B
FAM162A family with sequence similarity 162, member A
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GRIA2 glutamate receptor, ionotropic, AMPA 2
GSPT2 G1 to S phase transition 2
HBB hemoglobin, beta
HBP1 HMG-box transcription factor 1
HES1 hes family bHLH transcription factor 1
HILPDA hypoxia inducible lipid droplet-associated
HIST1H4C histone cluster 1, H4c
HMGA2 high mobility group AT-hook 2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
KIAA0101 KIAA0101
LAMA3 laminin, alpha 3
LAMA4 laminin, alpha 4
LAMB1 laminin, beta 1
LRRC17 leucine rich repeat containing 17
LYZ lysozyme
MAGED1 melanoma antigen family D1
MAPT microtubule-associated protein tau
MARCKSL1 MARCKS-like 1
MDK midkine (neurite growth-promoting factor 2)
MET MET proto-oncogene, receptor tyrosine kinase
MME membrane metallo-endopeptidase
MMP11 matrix metallopeptidase 11
MMP14 matrix metallopeptidase 14 (membrane-inserted)
NDRG2 NDRG family member 2
NRCAM neuronal cell adhesion molecule
NREP neuronal regeneration related protein
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCCB propionyl CoA carboxylase, beta polypeptide
PLIN2 perilipin 2
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RAD51AP1 RAD51 associated protein 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RNASE4 ribonuclease, RNase A family, 4
RRM2 ribonucleotide reductase M2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SCEL sciellin
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SKAP2 src kinase associated phosphoprotein 2
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SOX11 SRY (sex determining region Y)-box 11
SOX4 SRY (sex determining region Y)-box 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
THBD thrombomodulin
TMEM45A transmembrane protein 45A
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TOP2A topoisomerase (DNA) II alpha 170kDa
TPD52L1 tumor protein D52-like 1
TPP1 tripeptidyl peptidase I
TRD T cell receptor delta locus
TRIM2 tripartite motif containing 2
TRIM22 tripartite motif containing 22
TSPAN6 tetraspanin 6
TXNDC9 thioredoxin domain containing 9
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VCAM1 vascular cell adhesion molecule 1
WNT5A wingless-type MMTV integration site family, member 5A
WWTR1 WW domain containing transcription regulator 1
ZNF274 zinc finger protein 274
Funding