BRD-K45842176_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

45 genes differentially expressed following the BRD-K45842176_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AARS alanyl-tRNA synthetase
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
AUTS2 autism susceptibility candidate 2
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CD24 CD24 molecule
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CLU clusterin
CSTA cystatin A (stefin A)
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EGFR epidermal growth factor receptor
FBN2 fibrillin 2
FCMR Fc fragment of IgM receptor
GLTSCR2 glioma tumor suppressor candidate region gene 2
GUSBP3 glucuronidase, beta pseudogene 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
IGFBP7 insulin-like growth factor binding protein 7
INSIG1 insulin induced gene 1
KIAA0226L KIAA0226-like
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFIL3 nuclear factor, interleukin 3 regulated
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PSAT1 phosphoserine aminotransferase 1
RNASE4 ribonuclease, RNase A family, 4
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TRIB3 tribbles pseudokinase 3
VTCN1 V-set domain containing T cell activation inhibitor 1
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACP5 acid phosphatase 5, tartrate resistant
CCNE2 cyclin E2
CXCL9 chemokine (C-X-C motif) ligand 9
H3F3B H3 histone, family 3B (H3.3B)
PEG10 paternally expressed 10
TGFA transforming growth factor, alpha
TRIM2 tripartite motif containing 2
UBE2E3 ubiquitin-conjugating enzyme E2E 3