BRD-K46056750_AZD-7762_HCC515_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

222 genes differentially expressed following the BRD-K46056750_AZD-7762_HCC515_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
AMACR alpha-methylacyl-CoA racemase
APOD apolipoprotein D
ARID4B AT rich interactive domain 4B (RBP1-like)
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ASCL1 achaete-scute family bHLH transcription factor 1
AUH AU RNA binding protein/enoyl-CoA hydratase
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BBS1 Bardet-Biedl syndrome 1
BCL3 B-cell CLL/lymphoma 3
BCL6 B-cell CLL/lymphoma 6
C3 complement component 3
C6ORF48 chromosome 6 open reading frame 48
CAMLG calcium modulating ligand
CAPN1 calpain 1, (mu/I) large subunit
CCNG2 cyclin G2
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CFB complement factor B
CFD complement factor D (adipsin)
CLPTM1 cleft lip and palate associated transmembrane protein 1
COCH cochlin
CORO1B coronin, actin binding protein, 1B
CPD carboxypeptidase D
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CST3 cystatin C
CTSA cathepsin A
CTSC cathepsin C
CXCL5 chemokine (C-X-C motif) ligand 5
DDIT3 DNA-damage-inducible transcript 3
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DZIP3 DAZ interacting zinc finger protein 3
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENPEP glutamyl aminopeptidase (aminopeptidase A)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERGIC3 ERGIC and golgi 3
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F13A1 coagulation factor XIII, A1 polypeptide
FAM46A family with sequence similarity 46, member A
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXO4 forkhead box O4
FXYD2 FXYD domain containing ion transport regulator 2
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45B growth arrest and DNA-damage-inducible, beta
GNS glucosamine (N-acetyl)-6-sulfatase
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GOLGA8H golgin A8 family, member H
GRN granulin
GSDMB gasdermin B
GSTK1 glutathione S-transferase kappa 1
HCAR3 hydroxycarboxylic acid receptor 3
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST2H2BE histone cluster 2, H2be
HOXC6 homeobox C6
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IGBP1 immunoglobulin (CD79A) binding protein 1
IQCK IQ motif containing K
IRS2 insulin receptor substrate 2
JUN jun proto-oncogene
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KIF14 kinesin family member 14
KLHL24 kelch-like family member 24
KYNU kynureninase
LAMP1 lysosomal-associated membrane protein 1
LAMP2 lysosomal-associated membrane protein 2
LOC399491
MAOA monoamine oxidase A
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MUC1 mucin 1, cell surface associated
N4BP2L2 NEDD4 binding protein 2-like 2
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEU1 sialidase 1 (lysosomal sialidase)
NFIL3 nuclear factor, interleukin 3 regulated
NUSAP1 nucleolar and spindle associated protein 1
OBSL1 obscurin-like 1
OPN3 opsin 3
PAN2 PAN2 poly(A) specific ribonuclease subunit
PARP6 poly (ADP-ribose) polymerase family, member 6
PBX1 pre-B-cell leukemia homeobox 1
PDZK1 PDZ domain containing 1
PDZK1IP1 PDZK1 interacting protein 1
PILRB paired immunoglobin-like type 2 receptor beta
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PLEKHA5 pleckstrin homology domain containing, family A member 5
PNISR PNN-interacting serine/arginine-rich protein
PNRC1 proline-rich nuclear receptor coactivator 1
PROM1 prominin 1
QPCT glutaminyl-peptide cyclotransferase
RAD9A RAD9 homolog A (S. pombe)
RALGDS ral guanine nucleotide dissociation stimulator
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBBP6 retinoblastoma binding protein 6
RBM47 RNA binding motif protein 47
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RPS4Y1 ribosomal protein S4, Y-linked 1
RSRP1 arginine/serine-rich protein 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SYF2 SYF2 pre-mRNA-splicing factor
TFE3 transcription factor binding to IGHM enhancer 3
TM7SF2 transmembrane 7 superfamily member 2
TMEM176B transmembrane protein 176B
TPP1 tripeptidyl peptidase I
TUG1 taurine up-regulated 1 (non-protein coding)
TXNIP thioredoxin interacting protein
VCAN versican
VDAC1 voltage-dependent anion channel 1
XBP1 X-box binding protein 1
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ACOX2 acyl-CoA oxidase 2, branched chain
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANKRD1 ankyrin repeat domain 1 (cardiac muscle)
ANXA1 annexin A1
ARL4C ADP-ribosylation factor-like 4C
C1QBP complement component 1, q subcomponent binding protein
CALD1 caldesmon 1
CARD10 caspase recruitment domain family, member 10
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCND1 cyclin D1
CCNF cyclin F
CD58 CD58 molecule
CDK2 cyclin-dependent kinase 2
CNN3 calponin 3, acidic
COL5A1 collagen, type V, alpha 1
CPOX coproporphyrinogen oxidase
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DOK5 docking protein 5
DPYSL2 dihydropyrimidinase-like 2
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EIF4E eukaryotic translation initiation factor 4E
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENO2 enolase 2 (gamma, neuronal)
EPHA2 EPH receptor A2
EPHB2 EPH receptor B2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM57A family with sequence similarity 57, member A
FGFR3 fibroblast growth factor receptor 3
FKBP1A FK506 binding protein 1A, 12kDa
FOSL1 FOS-like antigen 1
FXYD5 FXYD domain containing ion transport regulator 5
GAL galanin/GMAP prepropeptide
GATA6 GATA binding protein 6
GCLM glutamate-cysteine ligase, modifier subunit
GPER1 G protein-coupled estrogen receptor 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
HAPLN1 hyaluronan and proteoglycan link protein 1
HEBP1 heme binding protein 1
HEPH hephaestin
HES1 hes family bHLH transcription factor 1
HSPA8 heat shock 70kDa protein 8
IGFBP3 insulin-like growth factor binding protein 3
IL1RL1 interleukin 1 receptor-like 1
IQGAP1 IQ motif containing GTPase activating protein 1
ITGA6 integrin, alpha 6
ITM2A integral membrane protein 2A
JAG1 jagged 1
KCTD12 potassium channel tetramerization domain containing 12
KRT13 keratin 13, type I
KRT15 keratin 15, type I
MCM6 minichromosome maintenance complex component 6
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MELK maternal embryonic leucine zipper kinase
MMP12 matrix metallopeptidase 12
MPZL2 myelin protein zero-like 2
MX1 MX dynamin-like GTPase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NES nestin
NOLC1 nucleolar and coiled-body phosphoprotein 1
NREP neuronal regeneration related protein
NT5E 5'-nucleotidase, ecto (CD73)
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAT plasminogen activator, tissue
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMP22 peripheral myelin protein 22
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSD3 pleckstrin and Sec7 domain containing 3
PSPH phosphoserine phosphatase
RAI14 retinoic acid induced 14
RGS4 regulator of G-protein signaling 4
RRM2 ribonucleotide reductase M2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SFN stratifin
SIK1 salt-inducible kinase 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC35F2 solute carrier family 35, member F2
SPRR3 small proline-rich protein 3
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TFRC transferrin receptor
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TM4SF1 transmembrane 4 L six family member 1
TMEM109 transmembrane protein 109
TMEM97 transmembrane protein 97
TPM1 tropomyosin 1 (alpha)
TRIB2 tribbles pseudokinase 2
TUBB6 tubulin, beta 6 class V
UXS1 UDP-glucuronate decarboxylase 1
Funding