BRD-K46056750_AZD-7762_MCF10A_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

168 genes differentially expressed following the BRD-K46056750_AZD-7762_MCF10A_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADGRG2 adhesion G protein-coupled receptor G2
ANXA4 annexin A4
APOD apolipoprotein D
ARMCX1 armadillo repeat containing, X-linked 1
BAX BCL2-associated X protein
BID BH3 interacting domain death agonist
BTG2 BTG family, member 2
C6ORF48 chromosome 6 open reading frame 48
CCNG1 cyclin G1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFB complement factor B
CFD complement factor D (adipsin)
COLEC12 collectin sub-family member 12
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CPE carboxypeptidase E
CXCL12 chemokine (C-X-C motif) ligand 12
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCN decorin
DDB2 damage-specific DNA binding protein 2, 48kDa
DES desmin
DPP4 dipeptidyl-peptidase 4
EXOSC4 exosome component 4
FAM13A family with sequence similarity 13, member A
FAS Fas cell surface death receptor
FAXDC2 fatty acid hydroxylase domain containing 2
FBLN1 fibulin 1
FDXR ferredoxin reductase
FILIP1L filamin A interacting protein 1-like
FOXO4 forkhead box O4
FTH1 ferritin, heavy polypeptide 1
GAS1 growth arrest-specific 1
GDF15 growth differentiation factor 15
GJA1 gap junction protein, alpha 1, 43kDa
GLRX glutaredoxin (thioltransferase)
GMPR guanosine monophosphate reductase
GPX1 glutathione peroxidase 1
GPX3 glutathione peroxidase 3
GSN gelsolin
GULP1 GULP, engulfment adaptor PTB domain containing 1
H2BFS H2B histone family, member S (pseudogene)
HBB hemoglobin, beta
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
HLA-B major histocompatibility complex, class I, B
HLA-E major histocompatibility complex, class I, E
HOXB2 homeobox B2
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
ISCU iron-sulfur cluster assembly enzyme
ISG15 ISG15 ubiquitin-like modifier
ITM2A integral membrane protein 2A
ITM2C integral membrane protein 2C
KIZ kizuna centrosomal protein
LAMP2 lysosomal-associated membrane protein 2
LGALS1 lectin, galactoside-binding, soluble, 1
LY96 lymphocyte antigen 96
MFAP5 microfibrillar associated protein 5
MT1F metallothionein 1F
MUC1 mucin 1, cell surface associated
MUC16 mucin 16, cell surface associated
NEFH neurofilament, heavy polypeptide
NFIL3 nuclear factor, interleukin 3 regulated
NOX4 NADPH oxidase 4
NPTX2 neuronal pentraxin II
NR4A2 nuclear receptor subfamily 4, group A, member 2
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAN2 PAN2 poly(A) specific ribonuclease subunit
PBX1 pre-B-cell leukemia homeobox 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDZK1IP1 PDZK1 interacting protein 1
PEX11A peroxisomal biogenesis factor 11 alpha
PFDN5 prefoldin subunit 5
PFKM phosphofructokinase, muscle
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLIN2 perilipin 2
PNRC1 proline-rich nuclear receptor coactivator 1
PRKCQ protein kinase C, theta
PRNP prion protein
PROM1 prominin 1
PRSS8 protease, serine, 8
RAB13 RAB13, member RAS oncogene family
RABAC1 Rab acceptor 1 (prenylated)
RABGAP1L RAB GTPase activating protein 1-like
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPS27L ribosomal protein S27-like
RTN2 reticulon 2
S100A4 S100 calcium binding protein A4
SALL2 spalt-like transcription factor 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SESN1 sestrin 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SPON2 spondin 2, extracellular matrix protein
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
TFPI2 tissue factor pathway inhibitor 2
TM7SF2 transmembrane 7 superfamily member 2
TMEM59 transmembrane protein 59
TOB1 transducer of ERBB2, 1
TPM2 tropomyosin 2 (beta)
TRIM22 tripartite motif containing 22
TSC22D3 TSC22 domain family, member 3
TUBA1A tubulin, alpha 1a
UQCRH ubiquinol-cytochrome c reductase hinge protein
XIST X inactive specific transcript (non-protein coding)
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
AUTS2 autism susceptibility candidate 2
BMP2 bone morphogenetic protein 2
CALU calumenin
CCNA2 cyclin A2
CD24 CD24 molecule
CDC6 cell division cycle 6
CHD7 chromodomain helicase DNA binding protein 7
COL4A2 collagen, type IV, alpha 2
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CYR61 cysteine-rich, angiogenic inducer, 61
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DICER1 dicer 1, ribonuclease type III
DKK1 dickkopf WNT signaling pathway inhibitor 1
EFHD1 EF-hand domain family, member D1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EREG epiregulin
F3 coagulation factor III (thromboplastin, tissue factor)
FOSL1 FOS-like antigen 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
HMGA2 high mobility group AT-hook 2
IL1B interleukin 1, beta
INHBA inhibin, beta A
ITGA6 integrin, alpha 6
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KLF6 Kruppel-like factor 6
MCM10 minichromosome maintenance complex component 10
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP12 matrix metallopeptidase 12
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NRG1 neuregulin 1
NRIP3 nuclear receptor interacting protein 3
PDLIM5 PDZ and LIM domain 5
PODXL podocalyxin-like
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
PTX3 pentraxin 3, long
S100A2 S100 calcium binding protein A2
SATB1 SATB homeobox 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
TM4SF1 transmembrane 4 L six family member 1
TPM4 tropomyosin 4
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
Funding