BRD-K46056750_AZD-7762_MCF7_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

74 genes differentially expressed following the BRD-K46056750_AZD-7762_MCF7_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANXA1 annexin A1
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
CADPS2 Ca++-dependent secretion activator 2
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CD163 CD163 molecule
CD36 CD36 molecule (thrombospondin receptor)
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CHN1 chimerin 1
COL1A1 collagen, type I, alpha 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ELOVL5 ELOVL fatty acid elongase 5
FOS FBJ murine osteosarcoma viral oncogene homolog
GLRX glutaredoxin (thioltransferase)
GLUL glutamate-ammonia ligase
GRB7 growth factor receptor-bound protein 7
HMGB2 high mobility group box 2
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HOPX HOP homeobox
HOXA5 homeobox A5
IGFBP5 insulin-like growth factor binding protein 5
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
LDLR low density lipoprotein receptor
LGALS1 lectin, galactoside-binding, soluble, 1
LPL lipoprotein lipase
MSMO1 methylsterol monooxygenase 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NCF2 neutrophil cytosolic factor 2
PAN2 PAN2 poly(A) specific ribonuclease subunit
PLK1 polo-like kinase 1
POSTN periostin, osteoblast specific factor
PRC1 protein regulator of cytokinesis 1
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
RPS4Y1 ribosomal protein S4, Y-linked 1
RSRP1 arginine/serine-rich protein 1
S100A8 S100 calcium binding protein A8
TMEM259 transmembrane protein 259
TMEM45A transmembrane protein 45A
TNIK TRAF2 and NCK interacting kinase
TOP2A topoisomerase (DNA) II alpha 170kDa
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
UBE2S ubiquitin-conjugating enzyme E2S
VCAN versican
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
DHRS2 dehydrogenase/reductase (SDR family) member 2
EDNRA endothelin receptor type A
EGFR epidermal growth factor receptor
EGR1 early growth response 1
FCGBP Fc fragment of IgG binding protein
HES1 hes family bHLH transcription factor 1
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
JAG1 jagged 1
KRT13 keratin 13, type I
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MAP1B microtubule-associated protein 1B
MX1 MX dynamin-like GTPase 1
NET1 neuroepithelial cell transforming 1
NREP neuronal regeneration related protein
S100P S100 calcium binding protein P
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SPP1 secreted phosphoprotein 1
XIST X inactive specific transcript (non-protein coding)
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
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