BRD-K46137903_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

80 genes differentially expressed following the BRD-K46137903_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AHR aryl hydrocarbon receptor
CAPN2 calpain 2, (m/II) large subunit
CCDC86 coiled-coil domain containing 86
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CSTA cystatin A (stefin A)
CTBP2 C-terminal binding protein 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DOCK9 dedicator of cytokinesis 9
ELANE elastase, neutrophil expressed
EVI2A ecotropic viral integration site 2A
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBB hemoglobin, beta
HOPX HOP homeobox
IFI6 interferon, alpha-inducible protein 6
KRT7 keratin 7, type II
LXN latexin
MAOA monoamine oxidase A
MMP7 matrix metallopeptidase 7
MNDA myeloid cell nuclear differentiation antigen
MT1F metallothionein 1F
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NT5E 5'-nucleotidase, ecto (CD73)
PDZK1IP1 PDZK1 interacting protein 1
PPOX protoporphyrinogen oxidase
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
S100A12 S100 calcium binding protein A12
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SGK1 serum/glucocorticoid regulated kinase 1
SH3YL1 SH3 and SYLF domain containing 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SRGN serglycin
TACSTD2 tumor-associated calcium signal transducer 2
TFPI2 tissue factor pathway inhibitor 2
VGLL1 vestigial-like family member 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
AEBP1 AE binding protein 1
AKR1C2 aldo-keto reductase family 1, member C2
ASCL1 achaete-scute family bHLH transcription factor 1
ASS1 argininosuccinate synthase 1
C1QA complement component 1, q subcomponent, A chain
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CLEC2B C-type lectin domain family 2, member B
COMP cartilage oligomeric matrix protein
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
FXYD6 FXYD domain containing ion transport regulator 6
GCH1 GTP cyclohydrolase 1
GPX2 glutathione peroxidase 2
IGFBP3 insulin-like growth factor binding protein 3
IGKV1-5 immunoglobulin kappa variable 1-5
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL13RA2 interleukin 13 receptor, alpha 2
ITM2A integral membrane protein 2A
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4
KDM5D lysine (K)-specific demethylase 5D
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LGALS4 lectin, galactoside-binding, soluble, 4
MAOB monoamine oxidase B
MFAP4 microfibrillar-associated protein 4
MYH11 myosin, heavy chain 11, smooth muscle
OLFM1 olfactomedin 1
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
RPS4Y1 ribosomal protein S4, Y-linked 1
SMAD1 SMAD family member 1
SNX7 sorting nexin 7
TFF3 trefoil factor 3 (intestinal)
TGFB3 transforming growth factor, beta 3
TIMP3 TIMP metallopeptidase inhibitor 3
TSPAN7 tetraspanin 7
ZW10 zw10 kinetochore protein