BRD-K46137903_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

119 genes differentially expressed following the BRD-K46137903_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADCY1 adenylate cyclase 1 (brain)
ADM adrenomedullin
AIM1 absent in melanoma 1
APOB apolipoprotein B
ARL4C ADP-ribosylation factor-like 4C
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
BEX4 brain expressed, X-linked 4
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CD40 CD40 molecule, TNF receptor superfamily member 5
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL1A2 collagen, type I, alpha 2
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCR4 chemokine (C-X-C motif) receptor 4
CYCS cytochrome c, somatic
DPYD dihydropyrimidine dehydrogenase
DRAM1 DNA-damage regulated autophagy modulator 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF5A eukaryotic translation initiation factor 5A
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EXT1 exostosin glycosyltransferase 1
FCHO1 FCH domain only 1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGFR2 fibroblast growth factor receptor 2
FILIP1L filamin A interacting protein 1-like
FZD5 frizzled class receptor 5
GATA3 GATA binding protein 3
GMPR guanosine monophosphate reductase
GPNMB glycoprotein (transmembrane) nmb
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOPX HOP homeobox
HOXB2 homeobox B2
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER5 immediate early response 5
IGFBP7 insulin-like growth factor binding protein 7
IL13RA1 interleukin 13 receptor, alpha 1
LUM lumican
MME membrane metallo-endopeptidase
MPZL2 myelin protein zero-like 2
MTFR1 mitochondrial fission regulator 1
NFE2L3 nuclear factor, erythroid 2-like 3
NOX4 NADPH oxidase 4
NRGN neurogranin (protein kinase C substrate, RC3)
NT5E 5'-nucleotidase, ecto (CD73)
ORC1 origin recognition complex, subunit 1
PDE4A phosphodiesterase 4A, cAMP-specific
PDPN podoplanin
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRR15L proline rich 15-like
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
SCPEP1 serine carboxypeptidase 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SHB Src homology 2 domain containing adaptor protein B
SHOX2 short stature homeobox 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SOCS2 suppressor of cytokine signaling 2
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STS steroid sulfatase (microsomal), isozyme S
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
THBS2 thrombospondin 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM176B transmembrane protein 176B
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TRIB3 tribbles pseudokinase 3
TRIM13 tripartite motif containing 13
TRIM2 tripartite motif containing 2

decreased expression

Symbol Name
ALDOA aldolase A, fructose-bisphosphate
ARMCX6 armadillo repeat containing, X-linked 6
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DLG5 discs, large homolog 5 (Drosophila)
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM46A family with sequence similarity 46, member A
FOLR1 folate receptor 1 (adult)
GPX3 glutathione peroxidase 3
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
KLHL21 kelch-like family member 21
KPNB1 karyopherin (importin) beta 1
LAPTM4B lysosomal protein transmembrane 4 beta
LPL lipoprotein lipase
MAMLD1 mastermind-like domain containing 1
NFIB nuclear factor I/B
PEBP1 phosphatidylethanolamine binding protein 1
PKN2 protein kinase N2
PLAC8 placenta-specific 8
PPIF peptidylprolyl isomerase F
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRKCZ protein kinase C, zeta
RPS11 ribosomal protein S11
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A2 S100 calcium binding protein A2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SFN stratifin
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TESC tescalcin
TFF3 trefoil factor 3 (intestinal)
TGFBR3 transforming growth factor, beta receptor III
THBS4 thrombospondin 4
TNPO1 transportin 1
TSPAN8 tetraspanin 8
WBSCR22 Williams Beuren syndrome chromosome region 22
Funding