BRD-K46419649_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

120 genes differentially expressed following the BRD-K46419649_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
BACE2 beta-site APP-cleaving enzyme 2
C9ORF3 chromosome 9 open reading frame 3
CXCL5 chemokine (C-X-C motif) ligand 5
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDB2 damage-specific DNA binding protein 2, 48kDa
ERBB3 erb-b2 receptor tyrosine kinase 3
FAM134B family with sequence similarity 134, member B
FOLR1 folate receptor 1 (adult)
HMG20B high mobility group 20B
HMOX1 heme oxygenase 1
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
KAZN kazrin, periplakin interacting protein
KIF20A kinesin family member 20A
NEFM neurofilament, medium polypeptide
PCDH9 protocadherin 9
PDZK1IP1 PDZK1 interacting protein 1
PENK proenkephalin
PNKP polynucleotide kinase 3'-phosphatase
PTPRC protein tyrosine phosphatase, receptor type, C
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RFC5 replication factor C (activator 1) 5, 36.5kDa
RNF167 ring finger protein 167
TPD52L1 tumor protein D52-like 1
TST thiosulfate sulfurtransferase (rhodanese)
TUSC3 tumor suppressor candidate 3
WNT5A wingless-type MMTV integration site family, member 5A

decreased expression

Symbol Name
ADORA2B adenosine A2b receptor
ALB albumin
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA3 annexin A3
AQP3 aquaporin 3 (Gill blood group)
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARL4C ADP-ribosylation factor-like 4C
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
BCAR3 breast cancer anti-estrogen resistance 3
C7 complement component 7
CCL20 chemokine (C-C motif) ligand 20
CCND1 cyclin D1
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CPE carboxypeptidase E
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EHD4 EH-domain containing 4
EMP1 epithelial membrane protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENOPH1 enolase-phosphatase 1
EPHA2 EPH receptor A2
EREG epiregulin
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FJX1 four jointed box 1 (Drosophila)
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GNAS GNAS complex locus
GPRC5A G protein-coupled receptor, class C, group 5, member A
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HMGA2 high mobility group AT-hook 2
HOPX HOP homeobox
HTRA1 HtrA serine peptidase 1
IER3 immediate early response 3
IFITM3 interferon induced transmembrane protein 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP3 insulin-like growth factor binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
JAG1 jagged 1
LAMC2 laminin, gamma 2
LDLR low density lipoprotein receptor
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MOK MOK protein kinase
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1HL1 metallothionein 1H-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYOF myoferlin
NET1 neuroepithelial cell transforming 1
NT5E 5'-nucleotidase, ecto (CD73)
NUAK1 NUAK family, SNF1-like kinase, 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
PLAUR plasminogen activator, urokinase receptor
PLK2 polo-like kinase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNP purine nucleoside phosphorylase
PODXL podocalyxin-like
PPAT phosphoribosyl pyrophosphate amidotransferase
PTPN12 protein tyrosine phosphatase, non-receptor type 12
SH2B3 SH2B adaptor protein 3
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SOX9 SRY (sex determining region Y)-box 9
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
STC1 stanniocalcin 1
STX1A syntaxin 1A (brain)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TMEM2 transmembrane protein 2
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
XIST X inactive specific transcript (non-protein coding)