BRD-K46531780_Methyl benzethonium chloride_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

193 genes differentially expressed following the BRD-K46531780_Methyl benzethonium chloride_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACBD3 acyl-CoA binding domain containing 3
ADM adrenomedullin
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX3 armadillo repeat containing, X-linked 3
ATF3 activating transcription factor 3
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BHLHE40 basic helix-loop-helix family, member e40
BTG1 B-cell translocation gene 1, anti-proliferative
C6ORF62 chromosome 6 open reading frame 62
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK17 cyclin-dependent kinase 17
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CEMIP cell migration inducing protein, hyaluronan binding
CFLAR CASP8 and FADD-like apoptosis regulator
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHN1 chimerin 1
CTH cystathionine gamma-lyase
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
F3 coagulation factor III (thromboplastin, tissue factor)
FADS1 fatty acid desaturase 1
FNDC3A fibronectin type III domain containing 3A
FOSL2 FOS-like antigen 2
FSCN1 fascin actin-bundling protein 1
FTH1 ferritin, heavy polypeptide 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GATAD1 GATA zinc finger domain containing 1
GCLC glutamate-cysteine ligase, catalytic subunit
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GOLT1B golgi transport 1B
GTPBP2 GTP binding protein 2
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HIST2H2BE histone cluster 2, H2be
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
JUN jun proto-oncogene
KLF6 Kruppel-like factor 6
KYNU kynureninase
LAMC2 laminin, gamma 2
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1B microtubule-associated protein 1B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MARCKS myristoylated alanine-rich protein kinase C substrate
MIR22HG MIR22 host gene
MSMO1 methylsterol monooxygenase 1
MT1X metallothionein 1X
MTSS1 metastasis suppressor 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
N4BP2L2 NEDD4 binding protein 2-like 2
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPC1 Niemann-Pick disease, type C1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRIP1 nuclear receptor interacting protein 1
NUPL1 nucleoporin like 1
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PELI1 pellino E3 ubiquitin protein ligase 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RABGGTB Rab geranylgeranyltransferase, beta subunit
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RIOK3 RIO kinase 3
RND3 Rho family GTPase 3
RPL37A ribosomal protein L37a
SDC4 syndecan 4
SEC24D SEC24 family member D
SEC31A SEC31 homolog A (S. cerevisiae)
SETD5 SET domain containing 5
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC38A1 solute carrier family 38, member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SMIM7 small integral membrane protein 7
SPG20 spastic paraplegia 20 (Troyer syndrome)
SWAP70 SWAP switching B-cell complex 70kDa subunit
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TARS threonyl-tRNA synthetase
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TES testin LIM domain protein
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
TUBB2B tubulin, beta 2B class IIb
TUFT1 tuftelin 1
TXNRD1 thioredoxin reductase 1
UFM1 ubiquitin-fold modifier 1
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
VEZF1 vascular endothelial zinc finger 1
WAC WW domain containing adaptor with coiled-coil
WIPI1 WD repeat domain, phosphoinositide interacting 1
WSB1 WD repeat and SOCS box containing 1
YARS tyrosyl-tRNA synthetase
ZFAND5 zinc finger, AN1-type domain 5
ZFP36 ZFP36 ring finger protein
ZNF24 zinc finger protein 24
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ASF1B anti-silencing function 1B histone chaperone
ATG3 autophagy related 3
B3GNT1
CDC45 cell division cycle 45
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CKLF chemokine-like factor
COX5B cytochrome c oxidase subunit Vb
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous)
DLK1 delta-like 1 homolog (Drosophila)
DUT deoxyuridine triphosphatase
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FEN1 flap structure-specific endonuclease 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GNAS GNAS complex locus
GRWD1 glutamate-rich WD repeat containing 1
GSTM3 glutathione S-transferase mu 3 (brain)
H2AFX H2A histone family, member X
HAT1 histone acetyltransferase 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
ICMT isoprenylcysteine carboxyl methyltransferase
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
KANK2 KN motif and ankyrin repeat domains 2
KIAA0101 KIAA0101
LIG1 ligase I, DNA, ATP-dependent
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MYBPC1 myosin binding protein C, slow type
MYCBP MYC binding protein
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
NPY1R neuropeptide Y receptor Y1
NT5DC2 5'-nucleotidase domain containing 2
PI3 peptidase inhibitor 3, skin-derived
PLBD1 phospholipase B domain containing 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PPIF peptidylprolyl isomerase F
PROM1 prominin 1
RNASEH2A ribonuclease H2, subunit A
RRM2 ribonucleotide reductase M2
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
SEPW1 selenoprotein W, 1
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SPINK5 serine peptidase inhibitor, Kazal type 5
STMN1 stathmin 1
TFDP1 transcription factor Dp-1
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TMEM109 transmembrane protein 109
TUBA1A tubulin, alpha 1a
TUBB tubulin, beta class I
TYRP1 tyrosinase-related protein 1
UBL5 ubiquitin-like 5
ZWINT ZW10 interacting kinetochore protein