BRD-K46531780_Methyl benzethonium chloride_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

320 genes differentially expressed following the BRD-K46531780_Methyl benzethonium chloride_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
AMIGO2 adhesion molecule with Ig-like domain 2
AMOTL2 angiomotin like 2
AQP1 aquaporin 1 (Colton blood group)
AQP3 aquaporin 3 (Gill blood group)
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BHLHE40 basic helix-loop-helix family, member e40
BTG1 B-cell translocation gene 1, anti-proliferative
C6ORF48 chromosome 6 open reading frame 48
CA2 carbonic anhydrase II
CAST calpastatin
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCDC28A coiled-coil domain containing 28A
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHN1 chimerin 1
CLCA4 chloride channel accessory 4
COL9A2 collagen, type IX, alpha 2
CPA3 carboxypeptidase A3 (mast cell)
CRISP3 cysteine-rich secretory protein 3
CTH cystathionine gamma-lyase
CXCL2 chemokine (C-X-C motif) ligand 2
CYBRD1 cytochrome b reductase 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EFNA1 ephrin-A1
EGFR epidermal growth factor receptor
EHF ets homologous factor
EPAS1 endothelial PAS domain protein 1
FAM129A family with sequence similarity 129, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FLOT1 flotillin 1
FOLR1 folate receptor 1 (adult)
FOXG1 forkhead box G1
FOXO4 forkhead box O4
GAB2 GRB2-associated binding protein 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GRB7 growth factor receptor-bound protein 7
GREM1 gremlin 1, DAN family BMP antagonist
GRIA2 glutamate receptor, ionotropic, AMPA 2
GSDMB gasdermin B
GTPBP2 GTP binding protein 2
H1F0 H1 histone family, member 0
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST2H2BE histone cluster 2, H2be
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
IFITM1 interferon induced transmembrane protein 1
INSIG1 insulin induced gene 1
IRF9 interferon regulatory factor 9
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KLF5 Kruppel-like factor 5 (intestinal)
KRT81 keratin 81, type II
LARP6 La ribonucleoprotein domain family, member 6
LETMD1 LETM1 domain containing 1
LGALS4 lectin, galactoside-binding, soluble, 4
LMO3 LIM domain only 3 (rhombotin-like 2)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
MEIS1 Meis homeobox 1
MFAP5 microfibrillar associated protein 5
MYO1D myosin ID
NCOA3 nuclear receptor coactivator 3
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NIT1 nitrilase 1
NPC1 Niemann-Pick disease, type C1
NT5E 5'-nucleotidase, ecto (CD73)
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
ORAI3 ORAI calcium release-activated calcium modulator 3
PAN2 PAN2 poly(A) specific ribonuclease subunit
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDE4DIP phosphodiesterase 4D interacting protein
PEG10 paternally expressed 10
PHGDH phosphoglycerate dehydrogenase
PNRC1 proline-rich nuclear receptor coactivator 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPOX protoporphyrinogen oxidase
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRSS8 protease, serine, 8
PSAT1 phosphoserine aminotransferase 1
PTPRO protein tyrosine phosphatase, receptor type, O
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic)
RAP1GAP RAP1 GTPase activating protein
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RGCC regulator of cell cycle
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNF19B ring finger protein 19B
S100A14 S100 calcium binding protein A14
S100A4 S100 calcium binding protein A4
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDC4 syndecan 4
SERINC3 serine incorporator 3
SERINC5 serine incorporator 5
SERP1 stress-associated endoplasmic reticulum protein 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SH3YL1 SH3 and SYLF domain containing 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC38A2 solute carrier family 38, member 2
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SQSTM1 sequestosome 1
TCEA1 transcription elongation factor A (SII), 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TPP1 tripeptidyl peptidase I
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
UBQLN2 ubiquilin 2
VEGFA vascular endothelial growth factor A
WBP2 WW domain binding protein 2
WDR13 WD repeat domain 13
WDR45 WD repeat domain 45
WNK1 WNK lysine deficient protein kinase 1
XBP1 X-box binding protein 1
YIPF3 Yip1 domain family, member 3
YPEL5 yippee-like 5 (Drosophila)
ZFAND1 zinc finger, AN1-type domain 1

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ACSL1 acyl-CoA synthetase long-chain family member 1
AK4 adenylate kinase 4
AKAP12 A kinase (PRKA) anchor protein 12
ALDOC aldolase C, fructose-bisphosphate
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
ATAD2 ATPase family, AAA domain containing 2
B3GNT1
BACE2 beta-site APP-cleaving enzyme 2
BAG2 BCL2-associated athanogene 2
BAG3 BCL2-associated athanogene 3
BLMH bleomycin hydrolase
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C14ORF169 chromosome 14 open reading frame 169
CAV1 caveolin 1, caveolae protein, 22kDa
CBR1 carbonyl reductase 1
CCDC86 coiled-coil domain containing 86
CCNA2 cyclin A2
CCND1 cyclin D1
CD3EAP CD3e molecule, epsilon associated protein
CDC123 cell division cycle 123
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CTPS1 CTP synthase 1
CTSZ cathepsin Z
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL8 chemokine (C-X-C motif) ligand 8
DCTPP1 dCTP pyrophosphatase 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ECI2 enoyl-CoA delta isomerase 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF4E eukaryotic translation initiation factor 4E
EIF5A eukaryotic translation initiation factor 5A
F12 coagulation factor XII (Hageman factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM216A family with sequence similarity 216, member A
FAM57A family with sequence similarity 57, member A
FEN1 flap structure-specific endonuclease 1
FERMT1 fermitin family member 1
FSTL1 follistatin-like 1
G0S2 G0/G1 switch 2
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GAL galanin/GMAP prepropeptide
GCLM glutamate-cysteine ligase, modifier subunit
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPX3 glutathione peroxidase 3
GSTM3 glutathione S-transferase mu 3 (brain)
HAT1 histone acetyltransferase 1
HCAR3 hydroxycarboxylic acid receptor 3
HN1 hematological and neurological expressed 1
HOMER1 homer scaffolding protein 1
HPRT1 hypoxanthine phosphoribosyltransferase 1
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
ICMT isoprenylcysteine carboxyl methyltransferase
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
IRF4 interferon regulatory factor 4
KCTD12 potassium channel tetramerization domain containing 12
LAMC1 laminin, gamma 1 (formerly LAMB2)
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LMNB2 lamin B2
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAPT microtubule-associated protein tau
MARCKSL1 MARCKS-like 1
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MEX3D mex-3 RNA binding family member D
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MSH6 mutS homolog 6
MTCL1 microtubule crosslinking factor 1
MTERF3 mitochondrial transcription termination factor 3
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYBPC1 myosin binding protein C, slow type
MYCBP MYC binding protein
NAAA N-acylethanolamine acid amidase
NAMPT nicotinamide phosphoribosyltransferase
NCAPD3 non-SMC condensin II complex, subunit D3
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NPM3 nucleophosmin/nucleoplasmin 3
NREP neuronal regeneration related protein
NUP210 nucleoporin 210kDa
OAT ornithine aminotransferase
ODC1 ornithine decarboxylase 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PARP1 poly (ADP-ribose) polymerase 1
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PFN2 profilin 2
PGAM1 phosphoglycerate mutase 1 (brain)
PGC progastricsin (pepsinogen C)
PHB prohibitin
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PLBD1 phospholipase B domain containing 1
PMPCA peptidase (mitochondrial processing) alpha
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR3G polymerase (RNA) III (DNA directed) polypeptide G (32kD)
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PPIF peptidylprolyl isomerase F
PRDX1 peroxiredoxin 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRR7 proline rich 7 (synaptic)
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
PTDSS1 phosphatidylserine synthase 1
PUS7 pseudouridylate synthase 7 (putative)
PXMP2 peroxisomal membrane protein 2, 22kDa
RBP1 retinol binding protein 1, cellular
RFC5 replication factor C (activator 1) 5, 36.5kDa
RGS2 regulator of G-protein signaling 2
RRM2 ribonucleotide reductase M2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUVBL1 RuvB-like AAA ATPase 1
SAC3D1 SAC3 domain containing 1
SACS sacsin molecular chaperone
SAMD4A sterile alpha motif domain containing 4A
SCARB1 scavenger receptor class B, member 1
SEPT11 septin 11
SFN stratifin
SFPQ splicing factor proline/glutamine-rich
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SLC35F2 solute carrier family 35, member F2
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
SNX10 sorting nexin 10
SORD sorbitol dehydrogenase
SRM spermidine synthase
SRSF7 serine/arginine-rich splicing factor 7
STMN1 stathmin 1
TESC tescalcin
TFRC transferrin receptor
TGM2 transglutaminase 2
TM4SF1 transmembrane 4 L six family member 1
TMEM14A transmembrane protein 14A
TRIP13 thyroid hormone receptor interactor 13
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSPAN8 tetraspanin 8
TUBB tubulin, beta class I
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
TUBB4B tubulin, beta 4B class IVb
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UMPS uridine monophosphate synthetase
UNG uracil-DNA glycosylase
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
VCAN versican
WWTR1 WW domain containing transcription regulator 1
ZMYM2 zinc finger, MYM-type 2