BRD-K47869605_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

96 genes differentially expressed following the BRD-K47869605_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AHSP alpha hemoglobin stabilizing protein
ALAS2 5'-aminolevulinate synthase 2
ANXA3 annexin A3
CALD1 caldesmon 1
CCDC86 coiled-coil domain containing 86
CHIC2 cysteine-rich hydrophobic domain 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
DDAH1 dimethylarginine dimethylaminohydrolase 1
DEPTOR DEP domain containing MTOR-interacting protein
EGFR epidermal growth factor receptor
EXT1 exostosin glycosyltransferase 1
FHL2 four and a half LIM domains 2
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
INHBB inhibin, beta B
JUN jun proto-oncogene
KIAA1033 KIAA1033
KLF5 Kruppel-like factor 5 (intestinal)
KLK11 kallikrein-related peptidase 11
KRT14 keratin 14, type I
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MT1X metallothionein 1X
MYC v-myc avian myelocytomatosis viral oncogene homolog
P3H2 prolyl 3-hydroxylase 2
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDLIM5 PDZ and LIM domain 5
PNMA2 paraneoplastic Ma antigen 2
PPOX protoporphyrinogen oxidase
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
RGS4 regulator of G-protein signaling 4
SAMD4A sterile alpha motif domain containing 4A
SCGB1D2 secretoglobin, family 1D, member 2
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFRP1 secreted frizzled-related protein 1
SGK1 serum/glucocorticoid regulated kinase 1
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SLPI secretory leukocyte peptidase inhibitor
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
TXNIP thioredoxin interacting protein
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AHR aryl hydrocarbon receptor
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
BAMBI BMP and activin membrane-bound inhibitor
CCND1 cyclin D1
CHGB chromogranin B
CIRBP cold inducible RNA binding protein
CXCL5 chemokine (C-X-C motif) ligand 5
DCLK1 doublecortin-like kinase 1
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP6 dual specificity phosphatase 6
EDNRB endothelin receptor type B
EPB41L3 erythrocyte membrane protein band 4.1-like 3
ERBB3 erb-b2 receptor tyrosine kinase 3
EXOSC4 exosome component 4
FHL1 four and a half LIM domains 1
FZD7 frizzled class receptor 7
GNG11 guanine nucleotide binding protein (G protein), gamma 11
HES1 hes family bHLH transcription factor 1
HIST1H2BK histone cluster 1, H2bk
HSPA1A heat shock 70kDa protein 1A
IER3 immediate early response 3
LEF1 lymphoid enhancer-binding factor 1
MARCKSL1 MARCKS-like 1
MDK midkine (neurite growth-promoting factor 2)
METRN meteorin, glial cell differentiation regulator
MFSD10 major facilitator superfamily domain containing 10
NPY1R neuropeptide Y receptor Y1
NQO1 NAD(P)H dehydrogenase, quinone 1
OLFM1 olfactomedin 1
PIR pirin (iron-binding nuclear protein)
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAB13 RAB13, member RAS oncogene family
RFC5 replication factor C (activator 1) 5, 36.5kDa
RPS4Y1 ribosomal protein S4, Y-linked 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCG2 secretogranin II
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SRPX sushi-repeat containing protein, X-linked
SRSF9 serine/arginine-rich splicing factor 9
TFF1 trefoil factor 1
THBS1 thrombospondin 1
TSPAN13 tetraspanin 13
TSPAN8 tetraspanin 8
WNT5A wingless-type MMTV integration site family, member 5A
ZMAT3 zinc finger, matrin-type 3