BRD-K47869605_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

126 genes differentially expressed following the BRD-K47869605_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTN1 actinin, alpha 1
ADD3 adducin 3 (gamma)
AKAP12 A kinase (PRKA) anchor protein 12
ANXA3 annexin A3
AREG amphiregulin
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATF3 activating transcription factor 3
BEX1 brain expressed, X-linked 1
CASP10 caspase 10, apoptosis-related cysteine peptidase
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC42 cell division cycle 42
CENPE centromere protein E, 312kDa
CHIC2 cysteine-rich hydrophobic domain 2
CLDN4 claudin 4
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CYR61 cysteine-rich, angiogenic inducer, 61
DDR1 discoidin domain receptor tyrosine kinase 1
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DENND5A DENN/MADD domain containing 5A
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EAPP E2F-associated phosphoprotein
EPCAM epithelial cell adhesion molecule
EPHA2 EPH receptor A2
EZR ezrin
F2RL1 coagulation factor II (thrombin) receptor-like 1
FLNB filamin B, beta
FOLR1 folate receptor 1 (adult)
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
GAL galanin/GMAP prepropeptide
GBP1 guanylate binding protein 1, interferon-inducible
GLIPR1 GLI pathogenesis-related 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
HNRNPL heterogeneous nuclear ribonucleoprotein L
ITGA6 integrin, alpha 6
KIAA1598
KLF6 Kruppel-like factor 6
KRT19 keratin 19, type I
KRT6B keratin 6B, type II
L1CAM L1 cell adhesion molecule
LDOC1 leucine zipper, down-regulated in cancer 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
MBOAT7 membrane bound O-acyltransferase domain containing 7
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NPC1 Niemann-Pick disease, type C1
PDLIM5 PDZ and LIM domain 5
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAC8 placenta-specific 8
RFK riboflavin kinase
RGS4 regulator of G-protein signaling 4
RHOB ras homolog family member B
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SIK1 salt-inducible kinase 1
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SMAD3 SMAD family member 3
SOX4 SRY (sex determining region Y)-box 4
SQRDL sulfide quinone reductase-like (yeast)
ST14 suppression of tumorigenicity 14 (colon carcinoma)
STX3 syntaxin 3
TEX10 testis expressed 10
THBS1 thrombospondin 1
TM4SF1 transmembrane 4 L six family member 1
TP53I3 tumor protein p53 inducible protein 3
TSC22D2 TSC22 domain family, member 2
UGCG UDP-glucose ceramide glucosyltransferase
VNN1 vanin 1
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae)
WAC WW domain containing adaptor with coiled-coil

decreased expression

Symbol Name
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
C14ORF132 chromosome 14 open reading frame 132
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CFB complement factor B
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CIAPIN1 cytokine induced apoptosis inhibitor 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL15A1 collagen, type XV, alpha 1
COL1A2 collagen, type I, alpha 2
COL21A1 collagen, type XXI, alpha 1
COL6A2 collagen, type VI, alpha 2
CPD carboxypeptidase D
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYBA cytochrome b-245, alpha polypeptide
DHFR dihydrofolate reductase
EML1 echinoderm microtubule associated protein like 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
F13A1 coagulation factor XIII, A1 polypeptide
FAM129A family with sequence similarity 129, member A
FAXDC2 fatty acid hydroxylase domain containing 2
FBLN1 fibulin 1
FGG fibrinogen gamma chain
GLUL glutamate-ammonia ligase
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GPM6B glycoprotein M6B
GULP1 GULP, engulfment adaptor PTB domain containing 1
IFITM1 interferon induced transmembrane protein 1
IGL immunoglobulin lambda locus
IL17RB interleukin 17 receptor B
LPAR6 lysophosphatidic acid receptor 6
LRRC17 leucine rich repeat containing 17
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MSH6 mutS homolog 6
MYBPC1 myosin binding protein C, slow type
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PLXND1 plexin D1
PPAP2B phosphatidic acid phosphatase type 2B
RNF130 ring finger protein 130
SCGB2A1 secretoglobin, family 2A, member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SHB Src homology 2 domain containing adaptor protein B
SMAD6 SMAD family member 6
SPDEF SAM pointed domain containing ETS transcription factor
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TMEM158 transmembrane protein 158 (gene/pseudogene)
TP63 tumor protein p63
VDAC1 voltage-dependent anion channel 1
WNT5A wingless-type MMTV integration site family, member 5A
Funding