BRD-K48488978_YM-201636_SKBR3_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

117 genes differentially expressed following the BRD-K48488978_YM-201636_SKBR3_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACTA1 actin, alpha 1, skeletal muscle
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTG2 actin, gamma 2, smooth muscle, enteric
ACTN2 actinin, alpha 2
ADRB2 adrenoceptor beta 2, surface
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
AGR2 anterior gradient 2
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
BHLHE40 basic helix-loop-helix family, member e40
CCNG2 cyclin G2
CD1C CD1c molecule
CD9 CD9 molecule
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKM creatine kinase, muscle
CPD carboxypeptidase D
CRISP3 cysteine-rich secretory protein 3
CRYAB crystallin, alpha B
CST1 cystatin SN
CTSW cathepsin W
CTSZ cathepsin Z
DES desmin
DHRS9 dehydrogenase/reductase (SDR family) member 9
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DSG3 desmoglein 3
E2F2 E2F transcription factor 2
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
FAS Fas cell surface death receptor
FLNA filamin A, alpha
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FZD7 frizzled class receptor 7
GAS1 growth arrest-specific 1
GNLY granulysin
GZMH granzyme H (cathepsin G-like 2, protein h-CCPX)
HOXC6 homeobox C6
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KLHL41 kelch-like family member 41
KRT19 keratin 19, type I
LCN2 lipocalin 2
LTF lactotransferrin
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAN2B1 mannosidase, alpha, class 2B, member 1
MB myoglobin
MYBPC1 myosin binding protein C, slow type
MYL1 myosin, light chain 1, alkali; skeletal, fast
MYOT myotilin
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
PDLIM3 PDZ and LIM domain 3
PITX1 paired-like homeodomain 1
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PSPH phosphoserine phosphatase
PTN pleiotrophin
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RAD51C RAD51 paralog C
RBM47 RNA binding motif protein 47
RCAN1 regulator of calcineurin 1
REG1A regenerating islet-derived 1 alpha
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SFTPA2 surfactant protein A2
SIM2 single-minded family bHLH transcription factor 2
SIX1 SIX homeobox 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLN sarcolipin
SMPX small muscle protein, X-linked
SNAP25 synaptosomal-associated protein, 25kDa
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
SYNE2 spectrin repeat containing, nuclear envelope 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF3 trefoil factor 3 (intestinal)
TNNC2 troponin C type 2 (fast)
TOB1 transducer of ERBB2, 1
TSPAN1 tetraspanin 1

decreased expression

Symbol Name
AREG amphiregulin
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CA2 carbonic anhydrase II
CD200 CD200 molecule
CFI complement factor I
COCH cochlin
CXCL14 chemokine (C-X-C motif) ligand 14
CYCS cytochrome c, somatic
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
F11R F11 receptor
FGFR2 fibroblast growth factor receptor 2
GJA1 gap junction protein, alpha 1, 43kDa
HACD3 3-hydroxyacyl-CoA dehydratase 3
HBB hemoglobin, beta
HSPA2 heat shock 70kDa protein 2
IL13RA1 interleukin 13 receptor, alpha 1
ITGB1BP1 integrin beta 1 binding protein 1
KRT23 keratin 23, type I
LARP1 La ribonucleoprotein domain family, member 1
LGALS4 lectin, galactoside-binding, soluble, 4
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1A1 mannosidase, alpha, class 1A, member 1
MCL1 myeloid cell leukemia 1
MTSS1 metastasis suppressor 1
PLIN2 perilipin 2
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RND3 Rho family GTPase 3
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
S100A7 S100 calcium binding protein A7
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC1 syndecan 1
SMAD1 SMAD family member 1
TF transferrin
TMEM176B transmembrane protein 176B
TMEM45A transmembrane protein 45A
TOX3 TOX high mobility group box family member 3
TSC22D2 TSC22 domain family, member 2
Funding