BRD-K48654774_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

136 genes differentially expressed following the BRD-K48654774_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AQP3 aquaporin 3 (Gill blood group)
AREG amphiregulin
ATF3 activating transcription factor 3
BEX1 brain expressed, X-linked 1
BMP2 bone morphogenetic protein 2
C10ORF10 chromosome 10 open reading frame 10
CCL20 chemokine (C-C motif) ligand 20
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CHIC2 cysteine-rich hydrophobic domain 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL6A2 collagen, type VI, alpha 2
CTGF connective tissue growth factor
CYR61 cysteine-rich, angiogenic inducer, 61
DLC1 DLC1 Rho GTPase activating protein
EGR1 early growth response 1
EGR3 early growth response 3
EMP1 epithelial membrane protein 1
EPHA2 EPH receptor A2
EREG epiregulin
FAM60A family with sequence similarity 60, member A
FHL2 four and a half LIM domains 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FXYD3 FXYD domain containing ion transport regulator 3
GABPB1 GA binding protein transcription factor, beta subunit 1
GEM GTP binding protein overexpressed in skeletal muscle
HAPLN1 hyaluronan and proteoglycan link protein 1
HBEGF heparin-binding EGF-like growth factor
HCAR3 hydroxycarboxylic acid receptor 3
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
INHBA inhibin, beta A
JAG1 jagged 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KDM6B lysine (K)-specific demethylase 6B
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
LYZ lysozyme
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCL1 myeloid cell leukemia 1
MGP matrix Gla protein
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFIL3 nuclear factor, interleukin 3 regulated
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
P3H2 prolyl 3-hydroxylase 2
PDGFA platelet-derived growth factor alpha polypeptide
PDLIM5 PDZ and LIM domain 5
PER1 period circadian clock 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAU plasminogen activator, urokinase
PLBD1 phospholipase B domain containing 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
RGS4 regulator of G-protein signaling 4
RND3 Rho family GTPase 3
S100A11 S100 calcium binding protein A11
S100A12 S100 calcium binding protein A12
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SMAD3 SMAD family member 3
SMAD7 SMAD family member 7
SOX9 SRY (sex determining region Y)-box 9
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SRGN serglycin
STC2 stanniocalcin 2
STOM stomatin
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THBD thrombomodulin
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
AURKA aurora kinase A
BASP1 brain abundant, membrane attached signal protein 1
BPIFA1 BPI fold containing family A, member 1
BRCA1 breast cancer 1, early onset
C6ORF62 chromosome 6 open reading frame 62
CANT1 calcium activated nucleotidase 1
CCNF cyclin F
CHRDL1 chordin-like 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP22 dual specificity phosphatase 22
DUSP3 dual specificity phosphatase 3
EIF5 eukaryotic translation initiation factor 5
FASTKD5 FAST kinase domains 5
FBXO9 F-box protein 9
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IGF1 insulin-like growth factor 1 (somatomedin C)
IGHD immunoglobulin heavy constant delta
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KIAA0125 KIAA0125
KIAA0907 KIAA0907
KRT7 keratin 7, type II
LINC00342 long intergenic non-protein coding RNA 342
METTL3 methyltransferase like 3
MUC16 mucin 16, cell surface associated
NDRG3 NDRG family member 3
NELL2 NEL-like 2 (chicken)
NRN1 neuritin 1
PARP2 poly (ADP-ribose) polymerase 2
PDE4DIP phosphodiesterase 4D interacting protein
PDZK1 PDZ domain containing 1
PNISR PNN-interacting serine/arginine-rich protein
PTP4A2 protein tyrosine phosphatase type IVA, member 2
RPS11 ribosomal protein S11
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC38A1 solute carrier family 38, member 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPON1 spondin 1, extracellular matrix protein
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TOP2A topoisomerase (DNA) II alpha 170kDa
TOX3 TOX high mobility group box family member 3
TRAK2 trafficking protein, kinesin binding 2
TTC3 tetratricopeptide repeat domain 3
USP34 ubiquitin specific peptidase 34
Funding