BRD-K48803730_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

113 genes differentially expressed following the BRD-K48803730_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C3 aldo-keto reductase family 1, member C3
AMDHD2 amidohydrolase domain containing 2
ANG angiogenin, ribonuclease, RNase A family, 5
BLNK B-cell linker
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CHRDL1 chordin-like 1
CLDN3 claudin 3
CX3CR1 chemokine (C-X3-C motif) receptor 1
DDAH1 dimethylarginine dimethylaminohydrolase 1
DDIT4 DNA-damage-inducible transcript 4
DHRS7 dehydrogenase/reductase (SDR family) member 7
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EIF5A eukaryotic translation initiation factor 5A
FABP4 fatty acid binding protein 4, adipocyte
FXYD6 FXYD domain containing ion transport regulator 6
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GLRX glutaredoxin (thioltransferase)
GRIA2 glutamate receptor, ionotropic, AMPA 2
GSDMB gasdermin B
GULP1 GULP, engulfment adaptor PTB domain containing 1
HEPH hephaestin
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HOXA5 homeobox A5
HOXB2 homeobox B2
HOXB7 homeobox B7
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
IER3 immediate early response 3
IGF1 insulin-like growth factor 1 (somatomedin C)
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIAA1598
LAPTM5 lysosomal protein transmembrane 5
LMO3 LIM domain only 3 (rhombotin-like 2)
LOC100505650 uncharacterized LOC100505650
LRRC17 leucine rich repeat containing 17
LXN latexin
MANSC1 MANSC domain containing 1
MEIS2 Meis homeobox 2
MLF1 myeloid leukemia factor 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMD monocyte to macrophage differentiation-associated
MME membrane metallo-endopeptidase
MMP10 matrix metallopeptidase 10
MORC4 MORC family CW-type zinc finger 4
MSN moesin
MSX1 msh homeobox 1
MTMR11 myotubularin related protein 11
MYO6 myosin VI
NES nestin
NMU neuromedin U
NRCAM neuronal cell adhesion molecule
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBX1 pre-B-cell leukemia homeobox 1
PDE4DIP phosphodiesterase 4D interacting protein
PDLIM3 PDZ and LIM domain 3
PERP PERP, TP53 apoptosis effector
PLIN2 perilipin 2
PROCR protein C receptor, endothelial
PRUNE2 prune homolog 2 (Drosophila)
PSAP prosaposin
PTN pleiotrophin
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RGS10 regulator of G-protein signaling 10
RNASE4 ribonuclease, RNase A family, 4
RTN2 reticulon 2
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDC3 syndecan 3
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SPON1 spondin 1, extracellular matrix protein
SYT1 synaptotagmin I
TBX3 T-box 3
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TMSB15A thymosin beta 15a
TPD52 tumor protein D52
TPM2 tropomyosin 2 (beta)
VAV3 vav 3 guanine nucleotide exchange factor
WASF3 WAS protein family, member 3
WWTR1 WW domain containing transcription regulator 1
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
AKAP8 A kinase (PRKA) anchor protein 8
ASS1 argininosuccinate synthase 1
AXIN1 axin 1
AZU1 azurocidin 1
BPIFA1 BPI fold containing family A, member 1
CCND1 cyclin D1
CLDN8 claudin 8
CRISP3 cysteine-rich secretory protein 3
CTSG cathepsin G
CXCL12 chemokine (C-X-C motif) ligand 12
ELANE elastase, neutrophil expressed
GOLGA8A golgin A8 family, member A
GRWD1 glutamate-rich WD repeat containing 1
IGFBP7 insulin-like growth factor binding protein 7
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A9 S100 calcium binding protein A9
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SPAG7 sperm associated antigen 7
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)
TATDN2 TatD DNase domain containing 2
THUMPD1 THUMP domain containing 1
TSTA3 tissue specific transplantation antigen P35B
Funding