BRD-K49010888_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

73 genes differentially expressed following the BRD-K49010888_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABLIM1 actin binding LIM protein 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANXA1 annexin A1
ANXA4 annexin A4
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXADR coxsackie virus and adenovirus receptor
DSP desmoplakin
DSTN destrin (actin depolymerizing factor)
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
ECM1 extracellular matrix protein 1
FADS1 fatty acid desaturase 1
HMOX1 heme oxygenase 1
HOPX HOP homeobox
IER3 immediate early response 3
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IRS2 insulin receptor substrate 2
KRT18 keratin 18, type I
KRT7 keratin 7, type II
KRT8 keratin 8, type II
KYNU kynureninase
LGALS1 lectin, galactoside-binding, soluble, 1
LIMCH1 LIM and calponin homology domains 1
MGP matrix Gla protein
MSLN mesothelin
MTMR11 myotubularin related protein 11
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NUPR1 nuclear protein, transcriptional regulator, 1
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PNKP polynucleotide kinase 3'-phosphatase
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RAB2A RAB2A, member RAS oncogene family
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RGS2 regulator of G-protein signaling 2
RGS5 regulator of G-protein signaling 5
S100A4 S100 calcium binding protein A4
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFN stratifin
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPRED2 sprouty-related, EVH1 domain containing 2
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
VNN1 vanin 1

decreased expression

Symbol Name
AK4 adenylate kinase 4
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNE2 cyclin E2
CHD7 chromodomain helicase DNA binding protein 7
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CXCL13 chemokine (C-X-C motif) ligand 13
EGFR epidermal growth factor receptor
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GOLGA8A golgin A8 family, member A
HES1 hes family bHLH transcription factor 1
LTF lactotransferrin
MEIS2 Meis homeobox 2
MT1X metallothionein 1X
NOP16 NOP16 nucleolar protein
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
POU2AF1 POU class 2 associating factor 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SFRP1 secreted frizzled-related protein 1
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
ZNF107 zinc finger protein 107
Funding