BRD-K49075727_nintedanib_A375_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

136 genes differentially expressed following the BRD-K49075727_nintedanib_A375_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ANXA4 annexin A4
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BMP4 bone morphogenetic protein 4
C1ORF115 chromosome 1 open reading frame 115
C3 complement component 3
CASP10 caspase 10, apoptosis-related cysteine peptidase
CAST calpastatin
CCNA1 cyclin A1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN2A cyclin-dependent kinase inhibitor 2A
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CNTNAP2 contactin associated protein-like 2
COLEC12 collectin sub-family member 12
CTSB cathepsin B
CTSZ cathepsin Z
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DHRS7 dehydrogenase/reductase (SDR family) member 7
DPP4 dipeptidyl-peptidase 4
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF5A eukaryotic translation initiation factor 5A
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FAM13A family with sequence similarity 13, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FN1 fibronectin 1
FTH1 ferritin, heavy polypeptide 1
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
GNPDA1 glucosamine-6-phosphate deaminase 1
GNS glucosamine (N-acetyl)-6-sulfatase
GPNMB glycoprotein (transmembrane) nmb
GYG1 glycogenin 1
HEXB hexosaminidase B (beta polypeptide)
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HMG20B high mobility group 20B
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI27 interferon, alpha-inducible protein 27
INSIG1 insulin induced gene 1
KDM5D lysine (K)-specific demethylase 5D
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MAGEA3 melanoma antigen family A3
MAOA monoamine oxidase A
MAP2K5 mitogen-activated protein kinase kinase 5
MEST mesoderm specific transcript
MME membrane metallo-endopeptidase
MSMO1 methylsterol monooxygenase 1
MYO6 myosin VI
NDFIP1 Nedd4 family interacting protein 1
NQO1 NAD(P)H dehydrogenase, quinone 1
OLFM4 olfactomedin 4
PAIP1 poly(A) binding protein interacting protein 1
PDZK1IP1 PDZK1 interacting protein 1
PHYH phytanoyl-CoA 2-hydroxylase
PPL periplakin
PROCR protein C receptor, endothelial
PRUNE2 prune homolog 2 (Drosophila)
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTGIS prostaglandin I2 (prostacyclin) synthase
PTPRO protein tyrosine phosphatase, receptor type, O
RCAN2 regulator of calcineurin 2
SCPEP1 serine carboxypeptidase 1
SDCBP syndecan binding protein (syntenin)
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SORD sorbitol dehydrogenase
SPON2 spondin 2, extracellular matrix protein
SPP1 secreted phosphoprotein 1
SQRDL sulfide quinone reductase-like (yeast)
SQSTM1 sequestosome 1
TKT transketolase
TUBA1A tubulin, alpha 1a
TXNIP thioredoxin interacting protein

decreased expression

Symbol Name
AREG amphiregulin
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa
BASP1 brain abundant, membrane attached signal protein 1
CA12 carbonic anhydrase XII
CAB39 calcium binding protein 39
CD59 CD59 molecule, complement regulatory protein
CHSY1 chondroitin sulfate synthase 1
CMTM6 CKLF-like MARVEL transmembrane domain containing 6
CRISP3 cysteine-rich secretory protein 3
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CSTA cystatin A (stefin A)
CXCL12 chemokine (C-X-C motif) ligand 12
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
FKBP11 FK506 binding protein 11, 19 kDa
FNBP1 formin binding protein 1
GADD45B growth arrest and DNA-damage-inducible, beta
HES1 hes family bHLH transcription factor 1
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1
ICAM3 intercellular adhesion molecule 3
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
LAMA3 laminin, alpha 3
LAMB3 laminin, beta 3
LAPTM5 lysosomal protein transmembrane 5
LPL lipoprotein lipase
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MARCKS myristoylated alanine-rich protein kinase C substrate
MOK MOK protein kinase
NOTCH2NL notch 2 N-terminal like
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PLAT plasminogen activator, tissue
PLK1 polo-like kinase 1
POSTN periostin, osteoblast specific factor
PPIF peptidylprolyl isomerase F
PURA purine-rich element binding protein A
QKI QKI, KH domain containing, RNA binding
RUNX3 runt-related transcription factor 3
S100A2 S100 calcium binding protein A2
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SNX11 sorting nexin 11
TRIM44 tripartite motif containing 44
TSPYL5 TSPY-like 5
UBE2E3 ubiquitin-conjugating enzyme E2E 3
USP6NL USP6 N-terminal like
XPO7 exportin 7
Funding