BRD-K49328571_dasatinib_BT20_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

103 genes differentially expressed following the BRD-K49328571_dasatinib_BT20_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
APOD apolipoprotein D
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARID5B AT rich interactive domain 5B (MRF1-like)
BCL6 B-cell CLL/lymphoma 6
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CFH complement factor H
CP ceruloplasmin (ferroxidase)
CYBA cytochrome b-245, alpha polypeptide
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FGFR2 fibroblast growth factor receptor 2
GRB14 growth factor receptor-bound protein 14
HES1 hes family bHLH transcription factor 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HIST1H1C histone cluster 1, H1c
HIST1H2BK histone cluster 1, H2bk
HNMT histamine N-methyltransferase
IGFBP1 insulin-like growth factor binding protein 1
KDM3A lysine (K)-specific demethylase 3A
MAPT microtubule-associated protein tau
MGLL monoglyceride lipase
PECR peroxisomal trans-2-enoyl-CoA reductase
PERP PERP, TP53 apoptosis effector
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PIP prolactin-induced protein
RPA2 replication protein A2, 32kDa
SEPP1 selenoprotein P, plasma, 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLPI secretory leukocyte peptidase inhibitor
TSC22D3 TSC22 domain family, member 3
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSPAN7 tetraspanin 7
TYRP1 tyrosinase-related protein 1
VAV3 vav 3 guanine nucleotide exchange factor

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
AEBP1 AE binding protein 1
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AP2B1 adaptor-related protein complex 2, beta 1 subunit
AREG amphiregulin
ARL4C ADP-ribosylation factor-like 4C
AXL AXL receptor tyrosine kinase
CD24 CD24 molecule
CDC20 cell division cycle 20
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
COL11A1 collagen, type XI, alpha 1
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
COL5A1 collagen, type V, alpha 1
COL5A2 collagen, type V, alpha 2
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTGF connective tissue growth factor
CYR61 cysteine-rich, angiogenic inducer, 61
DFNA5 deafness, autosomal dominant 5
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLC1 DLC1 Rho GTPase activating protein
DUSP14 dual specificity phosphatase 14
FBN2 fibrillin 2
FGFBP1 fibroblast growth factor binding protein 1
FHL2 four and a half LIM domains 2
FILIP1L filamin A interacting protein 1-like
FOSL1 FOS-like antigen 1
FSTL1 follistatin-like 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GPRC5A G protein-coupled receptor, class C, group 5, member A
HN1 hematological and neurological expressed 1
IGHM immunoglobulin heavy constant mu
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
KRT18 keratin 18, type I
LBH limb bud and heart development
LRRC17 leucine rich repeat containing 17
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYL9 myosin, light chain 9, regulatory
NEFH neurofilament, heavy polypeptide
NPR3 natriuretic peptide receptor 3
ODC1 ornithine decarboxylase 1
PLAU plasminogen activator, urokinase
PTRF polymerase I and transcript release factor
RBP1 retinol binding protein 1, cellular
RGS4 regulator of G-protein signaling 4
RRAS2 related RAS viral (r-ras) oncogene homolog 2
S100A2 S100 calcium binding protein A2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP1 secreted frizzled-related protein 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK1 serine peptidase inhibitor, Kazal type 1
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SULF1 sulfatase 1
TAGLN transgelin
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TM4SF1 transmembrane 4 L six family member 1
TP53I3 tumor protein p53 inducible protein 3
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
Funding