BRD-K49669041_BX-912_HEPG2_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

229 genes differentially expressed following the BRD-K49669041_BX-912_HEPG2_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
AGTR1 angiotensin II receptor, type 1
AKAP12 A kinase (PRKA) anchor protein 12
AKAP13 A kinase (PRKA) anchor protein 13
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA1 annexin A1
ANXA3 annexin A3
APOD apolipoprotein D
AREG amphiregulin
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATP9A ATPase, class II, type 9A
BBX bobby sox homolog (Drosophila)
C1ORF116 chromosome 1 open reading frame 116
CASP4 caspase 4, apoptosis-related cysteine peptidase
CD52 CD52 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD59 CD59 molecule, complement regulatory protein
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CFLAR CASP8 and FADD-like apoptosis regulator
CLEC2B C-type lectin domain family 2, member B
COTL1 coactosin-like F-actin binding protein 1
CRISP3 cysteine-rich secretory protein 3
CTGF connective tissue growth factor
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DHRS7 dehydrogenase/reductase (SDR family) member 7
DUSP22 dual specificity phosphatase 22
DUSP6 dual specificity phosphatase 6
EHF ets homologous factor
EMP1 epithelial membrane protein 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FHL2 four and a half LIM domains 2
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GPRC5A G protein-coupled receptor, class C, group 5, member A
GSN gelsolin
HECA headcase homolog (Drosophila)
HIST1H2AC histone cluster 1, H2ac
IFRD1 interferon-related developmental regulator 1
IGHM immunoglobulin heavy constant mu
INPP1 inositol polyphosphate-1-phosphatase
ITGA6 integrin, alpha 6
ITGB5 integrin, beta 5
KLF10 Kruppel-like factor 10
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KRT23 keratin 23, type I
LAMC1 laminin, gamma 1 (formerly LAMB2)
LCN2 lipocalin 2
LIMS1 LIM and senescent cell antigen-like domains 1
LPIN1 lipin 1
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1B microtubule-associated protein 1B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MBNL1 muscleblind-like splicing regulator 1
MGLL monoglyceride lipase
MIR22HG MIR22 host gene
MMP7 matrix metallopeptidase 7
MMRN1 multimerin 1
NEBL nebulette
PAM peptidylglycine alpha-amidating monooxygenase
PARVA parvin, alpha
PELI1 pellino E3 ubiquitin protein ligase 1
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PLCB4 phospholipase C, beta 4
PRNP prion protein
QPCT glutaminyl-peptide cyclotransferase
RGCC regulator of cell cycle
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SDCBP syndecan binding protein (syntenin)
SEPP1 selenoprotein P, plasma, 1
SERINC1 serine incorporator 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERTAD2 SERTA domain containing 2
SGK1 serum/glucocorticoid regulated kinase 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SMAD3 SMAD family member 3
SOX4 SRY (sex determining region Y)-box 4
SPTBN1 spectrin, beta, non-erythrocytic 1
STS steroid sulfatase (microsomal), isozyme S
STXBP1 syntaxin binding protein 1
TACSTD2 tumor-associated calcium signal transducer 2
TCF4 transcription factor 4
TFF1 trefoil factor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TM4SF1 transmembrane 4 L six family member 1
TMPRSS2 transmembrane protease, serine 2
TRAF5 TNF receptor-associated factor 5
TXN thioredoxin
TXNIP thioredoxin interacting protein
TXNRD1 thioredoxin reductase 1
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1
YBX3 Y box binding protein 3
ZMYND8 zinc finger, MYND-type containing 8

decreased expression

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ADIRF adipogenesis regulatory factor
AKAP1 A kinase (PRKA) anchor protein 1
ALG8 ALG8, alpha-1,3-glucosyltransferase
AMDHD2 amidohydrolase domain containing 2
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
C4BPA complement component 4 binding protein, alpha
C5 complement component 5
CADM1 cell adhesion molecule 1
CALR calreticulin
CASP8AP2 caspase 8 associated protein 2
CCNA2 cyclin A2
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CENPA centromere protein A
CEP55 centrosomal protein 55kDa
CFB complement factor B
CHEK2 checkpoint kinase 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CLU clusterin
COA3 cytochrome c oxidase assembly factor 3
COL1A2 collagen, type I, alpha 2
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CX3CR1 chemokine (C-X3-C motif) receptor 1
DCXR dicarbonyl/L-xylulose reductase
DHCR7 7-dehydrocholesterol reductase
DHFR dihydrofolate reductase
DMD dystrophin
EBP emopamil binding protein (sterol isomerase)
FASN fatty acid synthase
FEN1 flap structure-specific endonuclease 1
GALE UDP-galactose-4-epimerase
GAMT guanidinoacetate N-methyltransferase
GANAB glucosidase, alpha; neutral AB
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GCAT glycine C-acetyltransferase
GCDH glutaryl-CoA dehydrogenase
GGCT gamma-glutamylcyclotransferase
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GSTZ1 glutathione S-transferase zeta 1
H2AFX H2A histone family, member X
HILPDA hypoxia inducible lipid droplet-associated
HMMR hyaluronan-mediated motility receptor (RHAMM)
HMOX1 heme oxygenase 1
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIF18B kinesin family member 18B
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LIG1 ligase I, DNA, ATP-dependent
LOC100505650 uncharacterized LOC100505650
LUM lumican
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MEA1 male-enhanced antigen 1
MRPL12 mitochondrial ribosomal protein L12
MRPL57 mitochondrial ribosomal protein L57
MRPS12 mitochondrial ribosomal protein S12
MSMO1 methylsterol monooxygenase 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYLK myosin light chain kinase
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NPY1R neuropeptide Y receptor Y1
OIP5 Opa interacting protein 5
P4HB prolyl 4-hydroxylase, beta polypeptide
PAGR1 PAXIP1 associated glutamate-rich protein 1
PDZK1 PDZ domain containing 1
PIPOX pipecolic acid oxidase
POLD2 polymerase (DNA directed), delta 2, accessory subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
PRDX2 peroxiredoxin 2
PREB prolactin regulatory element binding
PRIM1 primase, DNA, polypeptide 1 (49kDa)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RBKS ribokinase
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RMI1 RecQ mediated genome instability 1
RNASEH2A ribonuclease H2, subunit A
RRM2 ribonucleotide reductase M2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDF2L1 stromal cell-derived factor 2-like 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11
SLC2A4RG SLC2A4 regulator
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SMC4 structural maintenance of chromosomes 4
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SORD sorbitol dehydrogenase
SRM spermidine synthase
STRA13 stimulated by retinoic acid 13
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SUZ12 SUZ12 polycomb repressive complex 2 subunit
TIAM1 T-cell lymphoma invasion and metastasis 1
TK1 thymidine kinase 1, soluble
TMEM5 transmembrane protein 5
TMEM97 transmembrane protein 97
TOP2A topoisomerase (DNA) II alpha 170kDa
TPSAB1 tryptase alpha/beta 1
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VDAC1 voltage-dependent anion channel 1
ZWINT ZW10 interacting kinetochore protein
Funding