BRD-K49669041_BX-912_PC3_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

125 genes differentially expressed following the BRD-K49669041_BX-912_PC3_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGR2 anterior gradient 2
ANXA4 annexin A4
ASS1 argininosuccinate synthase 1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BCL3 B-cell CLL/lymphoma 3
BIRC3 baculoviral IAP repeat containing 3
CCL20 chemokine (C-C motif) ligand 20
CCR7 chemokine (C-C motif) receptor 7
CD48 CD48 molecule
CD52 CD52 molecule
CD69 CD69 molecule
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CP ceruloplasmin (ferroxidase)
CTSB cathepsin B
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DLK1 delta-like 1 homolog (Drosophila)
ELF1 E74-like factor 1 (ets domain transcription factor)
F2RL1 coagulation factor II (thrombin) receptor-like 1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FN1 fibronectin 1
GBP1 guanylate binding protein 1, interferon-inducible
HIST1H2AC histone cluster 1, H2ac
HIST1H2BK histone cluster 1, H2bk
ICAM1 intercellular adhesion molecule 1
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL7R interleukin 7 receptor
ITK IL2-inducible T-cell kinase
KRT81 keratin 81, type II
KYNU kynureninase
LCN2 lipocalin 2
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LTBP1 latent transforming growth factor beta binding protein 1
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAST4 microtubule associated serine/threonine kinase family member 4
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
NEFL neurofilament, light polypeptide
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NR4A3 nuclear receptor subfamily 4, group A, member 3
PCP4 Purkinje cell protein 4
PDE4B phosphodiesterase 4B, cAMP-specific
PDZK1IP1 PDZK1 interacting protein 1
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
PLAT plasminogen activator, tissue
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PPAP2B phosphatidic acid phosphatase type 2B
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
QPCT glutaminyl-peptide cyclotransferase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS1 regulator of G-protein signaling 1
RHOQ ras homolog family member Q
SELL selectin L
SESN1 sestrin 1
SGK1 serum/glucocorticoid regulated kinase 1
SOD2 superoxide dismutase 2, mitochondrial
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
STS steroid sulfatase (microsomal), isozyme S
TBX2 T-box 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
TNC tenascin C
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TNIP1 TNFAIP3 interacting protein 1
TOB1 transducer of ERBB2, 1
TOX3 TOX high mobility group box family member 3
TRAC T cell receptor alpha constant
TRBC1 T cell receptor beta constant 1
XYLT1 xylosyltransferase I
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ABHD3 abhydrolase domain containing 3
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ATAD2 ATPase family, AAA domain containing 2
AURKB aurora kinase B
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CDT1 chromatin licensing and DNA replication factor 1
CEP55 centrosomal protein 55kDa
CFD complement factor D (adipsin)
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DPT dermatopontin
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EXO1 exonuclease 1
FEN1 flap structure-specific endonuclease 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GOLM1 golgi membrane protein 1
HELLS helicase, lymphoid-specific
KIF14 kinesin family member 14
LMNB1 lamin B1
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MKI67 marker of proliferation Ki-67
NCAPG non-SMC condensin I complex, subunit G
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
PARP2 poly (ADP-ribose) polymerase 2
PKP4 plakophilin 4
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PPARG peroxisome proliferator-activated receptor gamma
RAD51C RAD51 paralog C
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SPC25 SPC25, NDC80 kinetochore complex component
TEX30 testis expressed 30
TLR4 toll-like receptor 4
Funding