BRD-K49865102_PD-0325901_A549_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

306 genes differentially expressed following the BRD-K49865102_PD-0325901_A549_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5
ABHD4 abhydrolase domain containing 4
ABLIM1 actin binding LIM protein 1
ACSF2 acyl-CoA synthetase family member 2
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADGRG1 adhesion G protein-coupled receptor G1
ADIRF adipogenesis regulatory factor
AHNAK AHNAK nucleoprotein
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AMDHD2 amidohydrolase domain containing 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANPEP alanyl (membrane) aminopeptidase
ANXA4 annexin A4
APOA1 apolipoprotein A-I
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BIRC3 baculoviral IAP repeat containing 3
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
C3 complement component 3
C6ORF62 chromosome 6 open reading frame 62
CAST calpastatin
CCNG2 cyclin G2
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD59 CD59 molecule, complement regulatory protein
CFB complement factor B
CFI complement factor I
CGA glycoprotein hormones, alpha polypeptide
CKB creatine kinase, brain
CLU clusterin
COL4A1 collagen, type IV, alpha 1
COL5A1 collagen, type V, alpha 1
COMP cartilage oligomeric matrix protein
CRYAB crystallin, alpha B
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CTSZ cathepsin Z
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DCN decorin
DDAH2 dimethylarginine dimethylaminohydrolase 2
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DMD dystrophin
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DSP desmoplakin
DSTN destrin (actin depolymerizing factor)
DUSP1 dual specificity phosphatase 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNA1 ephrin-A1
EPS8L2 EPS8-like 2
ERBB2 erb-b2 receptor tyrosine kinase 2
FABP4 fatty acid binding protein 4, adipocyte
FAM134B family with sequence similarity 134, member B
FBN1 fibrillin 1
FILIP1L filamin A interacting protein 1-like
FKBP1B FK506 binding protein 1B, 12.6 kDa
FLRT3 fibronectin leucine rich transmembrane protein 3
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL2 FOS-like antigen 2
FOXC1 forkhead box C1
FSTL1 follistatin-like 1
FXYD3 FXYD domain containing ion transport regulator 3
GADD45B growth arrest and DNA-damage-inducible, beta
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GLS glutaminase
GLUL glutamate-ammonia ligase
GPRC5B G protein-coupled receptor, class C, group 5, member B
GSTA1 glutathione S-transferase alpha 1
HCLS1 hematopoietic cell-specific Lyn substrate 1
HIST3H2A histone cluster 3, H2a
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
HMOX1 heme oxygenase 1
HOXA5 homeobox A5
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IGFBP7 insulin-like growth factor binding protein 7
IGHM immunoglobulin heavy constant mu
IRF6 interferon regulatory factor 6
ISG15 ISG15 ubiquitin-like modifier
KLF2 Kruppel-like factor 2
KLF6 Kruppel-like factor 6
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT23 keratin 23, type I
KRT5 keratin 5, type II
KRT7 keratin 7, type II
LAMA3 laminin, alpha 3
LCN2 lipocalin 2
LOX lysyl oxidase
LPL lipoprotein lipase
LRRC16A leucine rich repeat containing 16A
LTBP1 latent transforming growth factor beta binding protein 1
LY75 lymphocyte antigen 75
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
METTL7A methyltransferase like 7A
MFAP5 microfibrillar associated protein 5
MSN moesin
MYO6 myosin VI
NDRG1 N-myc downstream regulated 1
NEBL nebulette
NFIL3 nuclear factor, interleukin 3 regulated
NMRK1 nicotinamide riboside kinase 1
NNMT nicotinamide N-methyltransferase
NPEPL1 aminopeptidase-like 1
NPTX2 neuronal pentraxin II
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NREP neuronal regeneration related protein
OBSL1 obscurin-like 1
OPTN optineurin
OXTR oxytocin receptor
PAN2 PAN2 poly(A) specific ribonuclease subunit
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFD platelet derived growth factor D
PDZK1IP1 PDZK1 interacting protein 1
PERP PERP, TP53 apoptosis effector
PHYH phytanoyl-CoA 2-hydroxylase
PMEPA1 prostate transmembrane protein, androgen induced 1
PROM1 prominin 1
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PXDN peroxidasin
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RCAN1 regulator of calcineurin 1
RHOQ ras homolog family member Q
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPL38 ribosomal protein L38
RUNX1 runt-related transcription factor 1
SATB1 SATB homeobox 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPP1 selenoprotein P, plasma, 1
SERINC3 serine incorporator 3
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SIK1 salt-inducible kinase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SST somatostatin
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SYNGR3 synaptogyrin 3
TACSTD2 tumor-associated calcium signal transducer 2
TAGLN2 transgelin 2
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TCEA2 transcription elongation factor A (SII), 2
TMEM45A transmembrane protein 45A
TNIP1 TNFAIP3 interacting protein 1
TRAM2 translocation associated membrane protein 2
TRIM22 tripartite motif containing 22
TRIM38 tripartite motif containing 38
TSKU tsukushi, small leucine rich proteoglycan
TXNIP thioredoxin interacting protein
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast)
VAMP8 vesicle-associated membrane protein 8
VAT1 vesicle amine transport 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ACD adrenocortical dysplasia homolog (mouse)
ADRB2 adrenoceptor beta 2, surface
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ANXA1 annexin A1
ARL4C ADP-ribosylation factor-like 4C
ASCL1 achaete-scute family bHLH transcription factor 1
BCHE butyrylcholinesterase
C5 complement component 5
CADPS2 Ca++-dependent secretion activator 2
CALML5 calmodulin-like 5
CAPN6 calpain 6
CCL2 chemokine (C-C motif) ligand 2
CCND1 cyclin D1
CD44 CD44 molecule (Indian blood group)
CD9 CD9 molecule
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKAP4 cytoskeleton-associated protein 4
COL4A6 collagen, type IV, alpha 6
CPB1 carboxypeptidase B1 (tissue)
CRIP1 cysteine-rich protein 1 (intestinal)
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
DDAH1 dimethylarginine dimethylaminohydrolase 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ETV1 ets variant 1
ETV5 ets variant 5
EXO1 exonuclease 1
FABP7 fatty acid binding protein 7, brain
FOSL1 FOS-like antigen 1
GEM GTP binding protein overexpressed in skeletal muscle
GINS2 GINS complex subunit 2 (Psf2 homolog)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GRWD1 glutamate-rich WD repeat containing 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HMGA2 high mobility group AT-hook 2
HOXB6 homeobox B6
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IGFBP5 insulin-like growth factor binding protein 5
IL13RA2 interleukin 13 receptor, alpha 2
ITM2A integral membrane protein 2A
KLK11 kallikrein-related peptidase 11
KRT13 keratin 13, type I
LMO3 LIM domain only 3 (rhombotin-like 2)
LPAR1 lysophosphatidic acid receptor 1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LTF lactotransferrin
LYZ lysozyme
MAL mal, T-cell differentiation protein
MALL mal, T-cell differentiation protein-like
MAN1C1 mannosidase, alpha, class 1C, member 1
MLPH melanophilin
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MYH11 myosin, heavy chain 11, smooth muscle
NEFL neurofilament, light polypeptide
NFIB nuclear factor I/B
NLGN4X neuroligin 4, X-linked
NOP56 NOP56 ribonucleoprotein
NPTX1 neuronal pentraxin I
NPY neuropeptide Y
NRGN neurogranin (protein kinase C substrate, RC3)
NT5E 5'-nucleotidase, ecto (CD73)
NTS neurotensin
ODC1 ornithine decarboxylase 1
ORC6 origin recognition complex, subunit 6
PCSK1 proprotein convertase subtilisin/kexin type 1
PDE4B phosphodiesterase 4B, cAMP-specific
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PITX1 paired-like homeodomain 1
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PLAC8 placenta-specific 8
PLK2 polo-like kinase 2
PNMAL1 paraneoplastic Ma antigen family-like 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRKCB protein kinase C, beta
PRKCH protein kinase C, eta
PRPF4 pre-mRNA processing factor 4
PTMA prothymosin, alpha
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RAD23B RAD23 homolog B (S. cerevisiae)
RAP1GAP RAP1 GTPase activating protein
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RGS2 regulator of G-protein signaling 2
RPIA ribose 5-phosphate isomerase A
RRM2 ribonucleotide reductase M2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A12 S100 calcium binding protein A12
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFRP1 secreted frizzled-related protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC35F2 solute carrier family 35, member F2
SOX9 SRY (sex determining region Y)-box 9
SPRED2 sprouty-related, EVH1 domain containing 2
SPRR1B small proline-rich protein 1B
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SQRDL sulfide quinone reductase-like (yeast)
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STC1 stanniocalcin 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
STK17A serine/threonine kinase 17a
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TIAM1 T-cell lymphoma invasion and metastasis 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNC tenascin C
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TXN thioredoxin
UBE2S ubiquitin-conjugating enzyme E2S
VCAN versican
XIST X inactive specific transcript (non-protein coding)
ZBTB18 zinc finger and BTB domain containing 18
Funding