BRD-K49865102_PD-0325901_HME1_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

130 genes differentially expressed following the BRD-K49865102_PD-0325901_HME1_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACKR3 atypical chemokine receptor 3
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTG2 actin, gamma 2, smooth muscle, enteric
C9ORF3 chromosome 9 open reading frame 3
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDH3 cadherin 3, type 1, P-cadherin (placental)
CELF2 CUGBP, Elav-like family member 2
CLIC3 chloride intracellular channel 3
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COMT catechol-O-methyltransferase
CREG1 cellular repressor of E1A-stimulated genes 1
CRYAB crystallin, alpha B
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCN decorin
DMD dystrophin
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNA1 ephrin-A1
EPHB2 EPH receptor B2
FABP7 fatty acid binding protein 7, brain
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GFOD1 glucose-fructose oxidoreductase domain containing 1
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GPM6A glycoprotein M6A
HIST1H2BG histone cluster 1, H2bg
HLA-B major histocompatibility complex, class I, B
HLA-F major histocompatibility complex, class I, F
HMOX1 heme oxygenase 1
HSPA2 heat shock 70kDa protein 2
HSPB1 heat shock 27kDa protein 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IL32 interleukin 32
MATN2 matrilin 2
MID1 midline 1
MYL9 myosin, light chain 9, regulatory
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NLGN4X neuroligin 4, X-linked
NOTCH1 notch 1
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM4 olfactomedin 4
OLFML2A olfactomedin-like 2A
OXTR oxytocin receptor
PCDH9 protocadherin 9
PCP4 Purkinje cell protein 4
POSTN periostin, osteoblast specific factor
PSAP prosaposin
REPIN1 replication initiator 1
S100A10 S100 calcium binding protein A10
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SPP1 secreted phosphoprotein 1
STK38L serine/threonine kinase 38 like
SULF1 sulfatase 1
SYT11 synaptotagmin XI
TAGLN transgelin
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPD52L1 tumor protein D52-like 1
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
TUBB2B tubulin, beta 2B class IIb
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
ZIC1 Zic family member 1

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
AKAP7 A kinase (PRKA) anchor protein 7
AREG amphiregulin
ASPH aspartate beta-hydroxylase
CCL19 chemokine (C-C motif) ligand 19
CEP57 centrosomal protein 57kDa
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL9 chemokine (C-X-C motif) ligand 9
DCLK1 doublecortin-like kinase 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EPCAM epithelial cell adhesion molecule
ETV1 ets variant 1
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GAL galanin/GMAP prepropeptide
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GULP1 GULP, engulfment adaptor PTB domain containing 1
GZMK granzyme K (granzyme 3; tryptase II)
HMGA1 high mobility group AT-hook 1
HMGA2 high mobility group AT-hook 2
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP4 insulin-like growth factor binding protein 4
IGHM immunoglobulin heavy constant mu
LPAR1 lysophosphatidic acid receptor 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MAP7 microtubule-associated protein 7
MMD monocyte to macrophage differentiation-associated
MMP1 matrix metallopeptidase 1
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
NELL2 NEL-like 2 (chicken)
NRGN neurogranin (protein kinase C substrate, RC3)
NRP1 neuropilin 1
NT5E 5'-nucleotidase, ecto (CD73)
NTS neurotensin
OLFM1 olfactomedin 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
PLAT plasminogen activator, tissue
PRSS2 protease, serine, 2 (trypsin 2)
RAB38 RAB38, member RAS oncogene family
RPA3 replication protein A3, 14kDa
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SPRY2 sprouty homolog 2 (Drosophila)
STEAP1 six transmembrane epithelial antigen of the prostate 1
STK39 serine threonine kinase 39
STX1A syntaxin 1A (brain)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM4SF1 transmembrane 4 L six family member 1
TRIB3 tribbles pseudokinase 3
UPP1 uridine phosphorylase 1
Funding