BRD-K49865102_PD-0325901_HME1_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

282 genes differentially expressed following the BRD-K49865102_PD-0325901_HME1_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABHD4 abhydrolase domain containing 4
ACKR3 atypical chemokine receptor 3
ACTA2 actin, alpha 2, smooth muscle, aorta
ADCY9 adenylate cyclase 9
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
ALAS2 5'-aminolevulinate synthase 2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANXA4 annexin A4
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
BLNK B-cell linker
BLVRB biliverdin reductase B
BTG1 B-cell translocation gene 1, anti-proliferative
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
C3 complement component 3
C9ORF3 chromosome 9 open reading frame 3
CA1 carbonic anhydrase I
CADM1 cell adhesion molecule 1
CCDC92 coiled-coil domain containing 92
CCL20 chemokine (C-C motif) ligand 20
CD58 CD58 molecule
CDH3 cadherin 3, type 1, P-cadherin (placental)
CELF2 CUGBP, Elav-like family member 2
CFB complement factor B
CFD complement factor D (adipsin)
CLIC3 chloride intracellular channel 3
CLU clusterin
CNN1 calponin 1, basic, smooth muscle
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CPQ carboxypeptidase Q
CREG1 cellular repressor of E1A-stimulated genes 1
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CRYAB crystallin, alpha B
CSRP2 cysteine and glycine-rich protein 2
CXADR coxsackie virus and adenovirus receptor
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DNASE2 deoxyribonuclease II, lysosomal
DSP desmoplakin
DST dystonin
DSTN destrin (actin depolymerizing factor)
E2F2 E2F transcription factor 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNA1 ephrin-A1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FOLR1 folate receptor 1 (adult)
FTH1 ferritin, heavy polypeptide 1
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GATA6 GATA binding protein 6
GBP1 guanylate binding protein 1, interferon-inducible
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
GREM1 gremlin 1, DAN family BMP antagonist
GRN granulin
HBB hemoglobin, beta
HEG1 heart development protein with EGF-like domains 1
HLA-B major histocompatibility complex, class I, B
HLA-F major histocompatibility complex, class I, F
HMOX1 heme oxygenase 1
HSPB1 heat shock 27kDa protein 1
HSPB8 heat shock 22kDa protein 8
ICAM1 intercellular adhesion molecule 1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IL15 interleukin 15
IL32 interleukin 32
IRF6 interferon regulatory factor 6
ISG15 ISG15 ubiquitin-like modifier
ITGAV integrin, alpha V
KLF4 Kruppel-like factor 4 (gut)
KRT13 keratin 13, type I
LCN2 lipocalin 2
LGALS3 lectin, galactoside-binding, soluble, 3
LIMS2 LIM and senescent cell antigen-like domains 2
LMOD1 leiomodin 1 (smooth muscle)
LUM lumican
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAN1A1 mannosidase, alpha, class 1A, member 1
MATN2 matrilin 2
MEIS1 Meis homeobox 1
METTL7A methyltransferase like 7A
MGP matrix Gla protein
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
MXRA5 matrix-remodelling associated 5
MYL9 myosin, light chain 9, regulatory
NCAM1 neural cell adhesion molecule 1
NDRG1 N-myc downstream regulated 1
NEFL neurofilament, light polypeptide
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM4 olfactomedin 4
OLFML2A olfactomedin-like 2A
ORAI3 ORAI calcium release-activated calcium modulator 3
OSR2 odd-skipped related transciption factor 2
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PALLD palladin, cytoskeletal associated protein
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFC platelet derived growth factor C
PERP PERP, TP53 apoptosis effector
PEX11A peroxisomal biogenesis factor 11 alpha
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLXNB2 plexin B2
PPIC peptidylprolyl isomerase C (cyclophilin C)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBKS ribokinase
RBP1 retinol binding protein 1, cellular
REG1A regenerating islet-derived 1 alpha
RIOK3 RIO kinase 3
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
S100A7 S100 calcium binding protein A7
SDC2 syndecan 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SELENBP1 selenium binding protein 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SIDT2 SID1 transmembrane family, member 2
SOD2 superoxide dismutase 2, mitochondrial
SORBS2 sorbin and SH3 domain containing 2
SPON2 spondin 2, extracellular matrix protein
SSBP2 single-stranded DNA binding protein 2
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STMN2 stathmin 2
SULF1 sulfatase 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
SYBU syntabulin (syntaxin-interacting)
TAGLN transgelin
TMEM45A transmembrane protein 45A
TMOD1 tropomodulin 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS1 tensin 1
TP53I3 tumor protein p53 inducible protein 3
TPD52L1 tumor protein D52-like 1
TPM1 tropomyosin 1 (alpha)
TPST2 tyrosylprotein sulfotransferase 2
TRIM16 tripartite motif containing 16
TSC22D3 TSC22 domain family, member 3
TUBA1A tubulin, alpha 1a
VAT1 vesicle amine transport 1
XIST X inactive specific transcript (non-protein coding)
XK X-linked Kx blood group
YPEL5 yippee-like 5 (Drosophila)
ZMAT3 zinc finger, matrin-type 3
ZMIZ1 zinc finger, MIZ-type containing 1
ZSCAN31 zinc finger and SCAN domain containing 31

decreased expression

Symbol Name
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMD1 adenosylmethionine decarboxylase 1
ANXA3 annexin A3
AREG amphiregulin
ARHGAP29 Rho GTPase activating protein 29
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ASPH aspartate beta-hydroxylase
AURKA aurora kinase A
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BIN1 bridging integrator 1
BIRC5 baculoviral IAP repeat containing 5
BOP1 block of proliferation 1
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C1QBP complement component 1, q subcomponent binding protein
CCNA2 cyclin A2
CCND1 cyclin D1
CD44 CD44 molecule (Indian blood group)
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COTL1 coactosin-like F-actin binding protein 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
CYTL1 cytokine-like 1
DBF4 DBF4 zinc finger
DCBLD2 discoidin, CUB and LCCL domain containing 2
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
ECT2 epithelial cell transforming 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EREG epiregulin
ETV1 ets variant 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FASN fatty acid synthase
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLRX glutaredoxin (thioltransferase)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
HIST1H4C histone cluster 1, H4c
HMGA1 high mobility group AT-hook 1
HMGA2 high mobility group AT-hook 2
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IER3 immediate early response 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
ITGB5 integrin, beta 5
KDM5D lysine (K)-specific demethylase 5D
KIF20A kinesin family member 20A
LBR lamin B receptor
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LPAR1 lysophosphatidic acid receptor 1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MLPH melanophilin
MRPL12 mitochondrial ribosomal protein L12
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
NAV3 neuron navigator 3
NET1 neuroepithelial cell transforming 1
NRP1 neuropilin 1
NT5E 5'-nucleotidase, ecto (CD73)
PA2G4 proliferation-associated 2G4, 38kDa
PCNA proliferating cell nuclear antigen
PDE4B phosphodiesterase 4B, cAMP-specific
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLK1 polo-like kinase 1
PNP purine nucleoside phosphorylase
PRSS23 protease, serine, 23
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
QDPR quinoid dihydropteridine reductase
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RANBP1 RAN binding protein 1
RPS4Y1 ribosomal protein S4, Y-linked 1
RRM2 ribonucleotide reductase M2
S100B S100 calcium binding protein B
SFRP1 secreted frizzled-related protein 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SMC4 structural maintenance of chromosomes 4
SOX9 SRY (sex determining region Y)-box 9
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SRM spermidine synthase
STEAP1 six transmembrane epithelial antigen of the prostate 1
STX1A syntaxin 1A (brain)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TACC3 transforming, acidic coiled-coil containing protein 3
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS4 thrombospondin 4
TM4SF1 transmembrane 4 L six family member 1
TNC tenascin C
TNNT1 troponin T type 1 (skeletal, slow)
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
ZC3H13 zinc finger CCCH-type containing 13
ZWINT ZW10 interacting kinetochore protein
Funding