Dataset | LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules |
Category | transcriptomics |
Type | small molecule perturbation |
Description | small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map) |
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415 genes differentially expressed following the BRD-K49865102_PD-0325901_MCF10A_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
Symbol | Name |
---|---|
1060P11.3 | killer cell immunoglobulin-like receptor, three domains, pseudogene |
ABCG1 | ATP-binding cassette, sub-family G (WHITE), member 1 |
ABHD4 | abhydrolase domain containing 4 |
ABLIM1 | actin binding LIM protein 1 |
ACKR3 | atypical chemokine receptor 3 |
ADIRF | adipogenesis regulatory factor |
AHNAK | AHNAK nucleoprotein |
AHNAK2 | AHNAK nucleoprotein 2 |
AKR1C1 | aldo-keto reductase family 1, member C1 |
AKR1C2 | aldo-keto reductase family 1, member C2 |
AKR1C3 | aldo-keto reductase family 1, member C3 |
ALCAM | activated leukocyte cell adhesion molecule |
ALDH3A2 | aldehyde dehydrogenase 3 family, member A2 |
ANXA4 | annexin A4 |
APOL1 | apolipoprotein L, 1 |
ARHGEF3 | Rho guanine nucleotide exchange factor (GEF) 3 |
ASS1 | argininosuccinate synthase 1 |
ATF3 | activating transcription factor 3 |
ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 |
BLVRB | biliverdin reductase B |
BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like |
BPGM | 2,3-bisphosphoglycerate mutase |
BPIFA1 | BPI fold containing family A, member 1 |
BST2 | bone marrow stromal cell antigen 2 |
BTG1 | B-cell translocation gene 1, anti-proliferative |
BTG2 | BTG family, member 2 |
C10ORF10 | chromosome 10 open reading frame 10 |
C1R | complement component 1, r subcomponent |
C1S | complement component 1, s subcomponent |
C3 | complement component 3 |
C9ORF3 | chromosome 9 open reading frame 3 |
CA12 | carbonic anhydrase XII |
CAPN1 | calpain 1, (mu/I) large subunit |
CAV1 | caveolin 1, caveolae protein, 22kDa |
CBLB | Cbl proto-oncogene B, E3 ubiquitin protein ligase |
CCNG2 | cyclin G2 |
CDH1 | cadherin 1, type 1, E-cadherin (epithelial) |
CDKN1C | cyclin-dependent kinase inhibitor 1C (p57, Kip2) |
CELF2 | CUGBP, Elav-like family member 2 |
CFB | complement factor B |
CFD | complement factor D (adipsin) |
CLIC5 | chloride intracellular channel 5 |
CLU | clusterin |
COL1A1 | collagen, type I, alpha 1 |
CP | ceruloplasmin (ferroxidase) |
CRYAB | crystallin, alpha B |
CSTA | cystatin A (stefin A) |
CTSD | cathepsin D |
CYP4B1 | cytochrome P450, family 4, subfamily B, polypeptide 1 |
DCN | decorin |
DDR1 | discoidin domain receptor tyrosine kinase 1 |
DEFB1 | defensin, beta 1 |
DIAPH2 | diaphanous-related formin 2 |
DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 |
DNAJC6 | DnaJ (Hsp40) homolog, subfamily C, member 6 |
DSP | desmoplakin |
EFEMP1 | EGF containing fibulin-like extracellular matrix protein 1 |
EFNA1 | ephrin-A1 |
EGLN3 | egl-9 family hypoxia-inducible factor 3 |
EPHX1 | epoxide hydrolase 1, microsomal (xenobiotic) |
EPS8L2 | EPS8-like 2 |
F11R | F11 receptor |
F13A1 | coagulation factor XIII, A1 polypeptide |
FAM134B | family with sequence similarity 134, member B |
FAM13B | family with sequence similarity 13, member B |
FBLN1 | fibulin 1 |
FBLN2 | fibulin 2 |
FGF9 | fibroblast growth factor 9 |
FXYD3 | FXYD domain containing ion transport regulator 3 |
GAA | glucosidase, alpha; acid |
GABARAPL1 | GABA(A) receptor-associated protein like 1 |
GADD45B | growth arrest and DNA-damage-inducible, beta |
GJA1 | gap junction protein, alpha 1, 43kDa |
GLUL | glutamate-ammonia ligase |
GM2A | GM2 ganglioside activator |
GOLGA8A | golgin A8 family, member A |
GPNMB | glycoprotein (transmembrane) nmb |
GSE1 | Gse1 coiled-coil protein |
GSN | gelsolin |
HCAR3 | hydroxycarboxylic acid receptor 3 |
HIST1H2AC | histone cluster 1, H2ac |
HIST1H2BD | histone cluster 1, H2bd |
HIST1H2BK | histone cluster 1, H2bk |
HLA-E | major histocompatibility complex, class I, E |
HPGD | hydroxyprostaglandin dehydrogenase 15-(NAD) |
HSPB8 | heat shock 22kDa protein 8 |
ID3 | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein |
IFI27 | interferon, alpha-inducible protein 27 |
IFI6 | interferon, alpha-inducible protein 6 |
IFITM1 | interferon induced transmembrane protein 1 |
IGFBP3 | insulin-like growth factor binding protein 3 |
IL18 | interleukin 18 |
IL1B | interleukin 1, beta |
ISG15 | ISG15 ubiquitin-like modifier |
ITGB4 | integrin, beta 4 |
KDM3A | lysine (K)-specific demethylase 3A |
KRT15 | keratin 15, type I |
KRT19 | keratin 19, type I |
KRT6A | keratin 6A, type II |
KRT8 | keratin 8, type II |
LAMP2 | lysosomal-associated membrane protein 2 |
LBH | limb bud and heart development |
LCN2 | lipocalin 2 |
LGALS3BP | lectin, galactoside-binding, soluble, 3 binding protein |
LRRC16A | leucine rich repeat containing 16A |
LTBP1 | latent transforming growth factor beta binding protein 1 |
MAF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog |
MAGED2 | melanoma antigen family D2 |
MAOA | monoamine oxidase A |
MFAP5 | microfibrillar associated protein 5 |
MME | membrane metallo-endopeptidase |
MTSS1 | metastasis suppressor 1 |
MUC1 | mucin 1, cell surface associated |
MVP | major vault protein |
MXRA5 | matrix-remodelling associated 5 |
MYL9 | myosin, light chain 9, regulatory |
NDRG1 | N-myc downstream regulated 1 |
NUPR1 | nuclear protein, transcriptional regulator, 1 |
OLFML2A | olfactomedin-like 2A |
OPLAH | 5-oxoprolinase (ATP-hydrolysing) |
OPTN | optineurin |
ORAI3 | ORAI calcium release-activated calcium modulator 3 |
PAK6 | p21 protein (Cdc42/Rac)-activated kinase 6 |
PALLD | palladin, cytoskeletal associated protein |
PAM | peptidylglycine alpha-amidating monooxygenase |
PBXIP1 | pre-B-cell leukemia homeobox interacting protein 1 |
PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) |
PDLIM1 | PDZ and LIM domain 1 |
PDZK1IP1 | PDZK1 interacting protein 1 |
PIK3C2B | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta |
PINK1 | PTEN induced putative kinase 1 |
PLEKHB1 | pleckstrin homology domain containing, family B (evectins) member 1 |
PLS3 | plastin 3 |
PPL | periplakin |
PROS1 | protein S (alpha) |
PRSS8 | protease, serine, 8 |
PTGES | prostaglandin E synthase |
PTGIS | prostaglandin I2 (prostacyclin) synthase |
PYCARD | PYD and CARD domain containing |
QPRT | quinolinate phosphoribosyltransferase |
RAB40B | RAB40B, member RAS oncogene family |
RABAC1 | Rab acceptor 1 (prenylated) |
RABGAP1L | RAB GTPase activating protein 1-like |
RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 |
RARRES3 | retinoic acid receptor responder (tazarotene induced) 3 |
RASSF2 | Ras association (RalGDS/AF-6) domain family member 2 |
RCN1 | reticulocalbin 1, EF-hand calcium binding domain |
RGS1 | regulator of G-protein signaling 1 |
RGS2 | regulator of G-protein signaling 2 |
S100A14 | S100 calcium binding protein A14 |
S100A4 | S100 calcium binding protein A4 |
SAT1 | spermidine/spermine N1-acetyltransferase 1 |
SCGB1A1 | secretoglobin, family 1A, member 1 (uteroglobin) |
SCNN1A | sodium channel, non voltage gated 1 alpha subunit |
SCPEP1 | serine carboxypeptidase 1 |
SEPP1 | selenoprotein P, plasma, 1 |
SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 |
SERPINF1 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 |
SH3BGRL | SH3 domain binding glutamate-rich protein like |
SH3YL1 | SH3 and SYLF domain containing 1 |
SIK1 | salt-inducible kinase 1 |
SLC1A1 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 |
SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 |
SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 |
SOD2 | superoxide dismutase 2, mitochondrial |
SORBS1 | sorbin and SH3 domain containing 1 |
SOX4 | SRY (sex determining region Y)-box 4 |
SPATA20 | spermatogenesis associated 20 |
SPINT1 | serine peptidase inhibitor, Kunitz type 1 |
SPINT2 | serine peptidase inhibitor, Kunitz type, 2 |
SPTSSA | serine palmitoyltransferase, small subunit A |
STC2 | stanniocalcin 2 |
STOM | stomatin |
STS | steroid sulfatase (microsomal), isozyme S |
SULF1 | sulfatase 1 |
SULT1A1 | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 |
SYBU | syntabulin (syntaxin-interacting) |
SYNE2 | spectrin repeat containing, nuclear envelope 2 |
TAPBP | TAP binding protein (tapasin) |
TCEAL4 | transcription elongation factor A (SII)-like 4 |
TLE1 | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) |
TM7SF2 | transmembrane 7 superfamily member 2 |
TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 |
TNS1 | tensin 1 |
TNXB | tenascin XB |
TP53I3 | tumor protein p53 inducible protein 3 |
TPM1 | tropomyosin 1 (alpha) |
TRIM16 | tripartite motif containing 16 |
TRIM22 | tripartite motif containing 22 |
TRIM29 | tripartite motif containing 29 |
TSC22D3 | TSC22 domain family, member 3 |
TXNIP | thioredoxin interacting protein |
UCP2 | uncoupling protein 2 (mitochondrial, proton carrier) |
UST | uronyl-2-sulfotransferase |
VAMP8 | vesicle-associated membrane protein 8 |
VAV3 | vav 3 guanine nucleotide exchange factor |
VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) |
WBP1L | WW domain binding protein 1-like |
WDR45 | WD repeat domain 45 |
WDTC1 | WD and tetratricopeptide repeats 1 |
WFDC2 | WAP four-disulfide core domain 2 |
WISP2 | WNT1 inducible signaling pathway protein 2 |
YPEL5 | yippee-like 5 (Drosophila) |
ZBTB16 | zinc finger and BTB domain containing 16 |
ZSCAN31 | zinc finger and SCAN domain containing 31 |
Symbol | Name |
---|---|
AKT3 | v-akt murine thymoma viral oncogene homolog 3 |
ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 |
ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E |
ANPEP | alanyl (membrane) aminopeptidase |
APOBEC3B | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B |
ASF1B | anti-silencing function 1B histone chaperone |
ASPH | aspartate beta-hydroxylase |
ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) |
ATAD2 | ATPase family, AAA domain containing 2 |
AURKA | aurora kinase A |
AURKB | aurora kinase B |
BCHE | butyrylcholinesterase |
BIRC5 | baculoviral IAP repeat containing 5 |
BMP2 | bone morphogenetic protein 2 |
BRCA1 | breast cancer 1, early onset |
BUB1 | BUB1 mitotic checkpoint serine/threonine kinase |
BZW1 | basic leucine zipper and W2 domains 1 |
CCNA2 | cyclin A2 |
CCNB1 | cyclin B1 |
CCNB2 | cyclin B2 |
CCND1 | cyclin D1 |
CCNF | cyclin F |
CDC20 | cell division cycle 20 |
CDC25A | cell division cycle 25A |
CDC45 | cell division cycle 45 |
CDC6 | cell division cycle 6 |
CDCA3 | cell division cycle associated 3 |
CDCA4 | cell division cycle associated 4 |
CDK1 | cyclin-dependent kinase 1 |
CDKN2C | cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) |
CDKN3 | cyclin-dependent kinase inhibitor 3 |
CENPA | centromere protein A |
CENPF | centromere protein F, 350/400kDa |
CENPN | centromere protein N |
CENPU | centromere protein U |
CEP55 | centrosomal protein 55kDa |
CKS1B | CDC28 protein kinase regulatory subunit 1B |
CKS2 | CDC28 protein kinase regulatory subunit 2 |
COTL1 | coactosin-like F-actin binding protein 1 |
CSE1L | CSE1 chromosome segregation 1-like (yeast) |
CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) |
CXCL8 | chemokine (C-X-C motif) ligand 8 |
CXCL9 | chemokine (C-X-C motif) ligand 9 |
CYR61 | cysteine-rich, angiogenic inducer, 61 |
DBF4 | DBF4 zinc finger |
DEPDC1 | DEP domain containing 1 |
DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 |
DNAJC9 | DnaJ (Hsp40) homolog, subfamily C, member 9 |
DONSON | downstream neighbor of SON |
DTL | denticleless E3 ubiquitin protein ligase homolog (Drosophila) |
DUSP2 | dual specificity phosphatase 2 |
DUSP4 | dual specificity phosphatase 4 |
DUSP6 | dual specificity phosphatase 6 |
ECT2 | epithelial cell transforming 2 |
EFHD2 | EF-hand domain family, member D2 |
EGR1 | early growth response 1 |
EGR2 | early growth response 2 |
EGR3 | early growth response 3 |
EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 |
EIF5 | eukaryotic translation initiation factor 5 |
ELANE | elastase, neutrophil expressed |
ELOVL2 | ELOVL fatty acid elongase 2 |
EREG | epiregulin |
ESPL1 | extra spindle pole bodies homolog 1 (S. cerevisiae) |
ETV1 | ets variant 1 |
ETV5 | ets variant 5 |
EXO1 | exonuclease 1 |
EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit |
FANCG | Fanconi anemia, complementation group G |
FANCI | Fanconi anemia, complementation group I |
FBXO5 | F-box protein 5 |
FEN1 | flap structure-specific endonuclease 1 |
FGFR3 | fibroblast growth factor receptor 3 |
FOSL1 | FOS-like antigen 1 |
FOXM1 | forkhead box M1 |
GAL | galanin/GMAP prepropeptide |
GINS1 | GINS complex subunit 1 (Psf1 homolog) |
GINS2 | GINS complex subunit 2 (Psf2 homolog) |
GTSE1 | G-2 and S-phase expressed 1 |
H2AFX | H2A histone family, member X |
HBEGF | heparin-binding EGF-like growth factor |
HHEX | hematopoietically expressed homeobox |
HIST1H4C | histone cluster 1, H4c |
HJURP | Holliday junction recognition protein |
HMGA1 | high mobility group AT-hook 1 |
HMGA2 | high mobility group AT-hook 2 |
HMGB2 | high mobility group box 2 |
HMMR | hyaluronan-mediated motility receptor (RHAMM) |
HSPD1 | heat shock 60kDa protein 1 (chaperonin) |
IER3 | immediate early response 3 |
IFRD2 | interferon-related developmental regulator 2 |
IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 |
IL13RA2 | interleukin 13 receptor, alpha 2 |
IL17RB | interleukin 17 receptor B |
JMJD6 | jumonji domain containing 6 |
KIAA0101 | KIAA0101 |
KIF11 | kinesin family member 11 |
KIF14 | kinesin family member 14 |
KIF15 | kinesin family member 15 |
KIF18B | kinesin family member 18B |
KIF20A | kinesin family member 20A |
KIF4A | kinesin family member 4A |
LBR | lamin B receptor |
LIF | leukemia inhibitory factor |
LIG1 | ligase I, DNA, ATP-dependent |
LMNB1 | lamin B1 |
MAD2L1 | MAD2 mitotic arrest deficient-like 1 (yeast) |
MALL | mal, T-cell differentiation protein-like |
MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 |
MCM10 | minichromosome maintenance complex component 10 |
MCM2 | minichromosome maintenance complex component 2 |
MCM3 | minichromosome maintenance complex component 3 |
MCM4 | minichromosome maintenance complex component 4 |
MCM5 | minichromosome maintenance complex component 5 |
MCM6 | minichromosome maintenance complex component 6 |
MCM7 | minichromosome maintenance complex component 7 |
MELK | maternal embryonic leucine zipper kinase |
MKI67 | marker of proliferation Ki-67 |
MMP9 | matrix metallopeptidase 9 |
MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 |
MYBPC1 | myosin binding protein C, slow type |
NAV3 | neuron navigator 3 |
NCAPG | non-SMC condensin I complex, subunit G |
NCAPG2 | non-SMC condensin II complex, subunit G2 |
NCAPH | non-SMC condensin I complex, subunit H |
NDC80 | NDC80 kinetochore complex component |
NEIL3 | nei endonuclease VIII-like 3 (E. coli) |
NEK2 | NIMA-related kinase 2 |
NETO2 | neuropilin (NRP) and tolloid (TLL)-like 2 |
NFIB | nuclear factor I/B |
NPTX2 | neuronal pentraxin II |
NT5E | 5'-nucleotidase, ecto (CD73) |
PARP2 | poly (ADP-ribose) polymerase 2 |
PBK | PDZ binding kinase |
PCNA | proliferating cell nuclear antigen |
PCSK1 | proprotein convertase subtilisin/kexin type 1 |
PDE4B | phosphodiesterase 4B, cAMP-specific |
PHGDH | phosphoglycerate dehydrogenase |
PHLDA1 | pleckstrin homology-like domain, family A, member 1 |
PHLDA2 | pleckstrin homology-like domain, family A, member 2 |
PLAT | plasminogen activator, tissue |
PLK1 | polo-like kinase 1 |
PLK4 | polo-like kinase 4 |
POLE2 | polymerase (DNA directed), epsilon 2, accessory subunit |
POLR3G | polymerase (RNA) III (DNA directed) polypeptide G (32kD) |
PRC1 | protein regulator of cytokinesis 1 |
PRIM1 | primase, DNA, polypeptide 1 (49kDa) |
PRKD3 | protein kinase D3 |
PRPF4 | pre-mRNA processing factor 4 |
PRSS3 | protease, serine, 3 |
PSAT1 | phosphoserine aminotransferase 1 |
PTTG1 | pituitary tumor-transforming 1 |
RAC2 | ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) |
RACGAP1 | Rac GTPase activating protein 1 |
RAD51AP1 | RAD51 associated protein 1 |
RANBP1 | RAN binding protein 1 |
RFC2 | replication factor C (activator 1) 2, 40kDa |
RFC3 | replication factor C (activator 1) 3, 38kDa |
RFC4 | replication factor C (activator 1) 4, 37kDa |
RFC5 | replication factor C (activator 1) 5, 36.5kDa |
RPS11 | ribosomal protein S11 |
RRM1 | ribonucleotide reductase M1 |
RRM2 | ribonucleotide reductase M2 |
S100A12 | S100 calcium binding protein A12 |
SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 |
SFRP1 | secreted frizzled-related protein 1 |
SH2B3 | SH2B adaptor protein 3 |
SHCBP1 | SHC SH2-domain binding protein 1 |
SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 |
SMC2 | structural maintenance of chromosomes 2 |
SMC4 | structural maintenance of chromosomes 4 |
SNRPB | small nuclear ribonucleoprotein polypeptides B and B1 |
SOX9 | SRY (sex determining region Y)-box 9 |
SPAG5 | sperm associated antigen 5 |
SPARC | secreted protein, acidic, cysteine-rich (osteonectin) |
SPATS2L | spermatogenesis associated, serine-rich 2-like |
SPC25 | SPC25, NDC80 kinetochore complex component |
SPDL1 | spindle apparatus coiled-coil protein 1 |
SPHK1 | sphingosine kinase 1 |
SPRY1 | sprouty homolog 1, antagonist of FGF signaling (Drosophila) |
SPRY2 | sprouty homolog 2 (Drosophila) |
SPRY4 | sprouty homolog 4 (Drosophila) |
SRGN | serglycin |
SRM | spermidine synthase |
STEAP1 | six transmembrane epithelial antigen of the prostate 1 |
STX1A | syntaxin 1A (brain) |
SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) |
TACC3 | transforming, acidic coiled-coil containing protein 3 |
TIPIN | TIMELESS interacting protein |
TMEM158 | transmembrane protein 158 (gene/pseudogene) |
TMEM97 | transmembrane protein 97 |
TMPO | thymopoietin |
TNC | tenascin C |
TOP2A | topoisomerase (DNA) II alpha 170kDa |
TPX2 | TPX2, microtubule-associated |
TRIP13 | thyroid hormone receptor interactor 13 |
TROAP | trophinin associated protein |
TSPAN4 | tetraspanin 4 |
TTK | TTK protein kinase |
TUBB4B | tubulin, beta 4B class IVb |
TYMS | thymidylate synthetase |
UBE2C | ubiquitin-conjugating enzyme E2C |
UBE2S | ubiquitin-conjugating enzyme E2S |
UCHL5 | ubiquitin carboxyl-terminal hydrolase L5 |
UPP1 | uridine phosphorylase 1 |
USP1 | ubiquitin specific peptidase 1 |
VRK1 | vaccinia related kinase 1 |
YKT6 | YKT6 v-SNARE homolog (S. cerevisiae) |
ZWILCH | zwilch kinetochore protein |
ZWINT | ZW10 interacting kinetochore protein |