BRD-K49865102_PD-0325901_MDAMB231_3_h_0.12_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

96 genes differentially expressed following the BRD-K49865102_PD-0325901_MDAMB231_3_h_0.12_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ADA adenosine deaminase
ATF3 activating transcription factor 3
BAMBI BMP and activin membrane-bound inhibitor
CEMIP cell migration inducing protein, hyaluronan binding
COL3A1 collagen, type III, alpha 1
CPE carboxypeptidase E
DHRS2 dehydrogenase/reductase (SDR family) member 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EPAS1 endothelial PAS domain protein 1
GLO1 glyoxalase I
HIST1H1C histone cluster 1, H1c
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HOPX HOP homeobox
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGFBP5 insulin-like growth factor binding protein 5
ITM2A integral membrane protein 2A
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
PIR pirin (iron-binding nuclear protein)
PLCB4 phospholipase C, beta 4
PRAME preferentially expressed antigen in melanoma
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
SATB1 SATB homeobox 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLPI secretory leukocyte peptidase inhibitor
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
XIST X inactive specific transcript (non-protein coding)
ZFPM2 zinc finger protein, FOG family member 2

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADRB2 adrenoceptor beta 2, surface
APOD apolipoprotein D
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BIRC2 baculoviral IAP repeat containing 2
CAST calpastatin
CHMP4A charged multivesicular body protein 4A
CHN1 chimerin 1
CRISP3 cysteine-rich secretory protein 3
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EFNB2 ephrin-B2
EGR3 early growth response 3
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPCAM epithelial cell adhesion molecule
ETV1 ets variant 1
FAM46A family with sequence similarity 46, member A
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GAL galanin/GMAP prepropeptide
HBEGF heparin-binding EGF-like growth factor
HMGA2 high mobility group AT-hook 2
IER3 immediate early response 3
IER5 immediate early response 5
KIAA1598
KLF10 Kruppel-like factor 10
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
MARCKS myristoylated alanine-rich protein kinase C substrate
MBP myelin basic protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
NKX3-1 NK3 homeobox 1
NOTCH2 notch 2
NPY neuropeptide Y
NRGN neurogranin (protein kinase C substrate, RC3)
OSBPL10 oxysterol binding protein-like 10
PAN2 PAN2 poly(A) specific ribonuclease subunit
PARP8 poly (ADP-ribose) polymerase family, member 8
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PROM1 prominin 1
RPS4Y1 ribosomal protein S4, Y-linked 1
SCG5 secretogranin V
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SFRP1 secreted frizzled-related protein 1
SNAP25 synaptosomal-associated protein, 25kDa
SOSTDC1 sclerostin domain containing 1
SOX9 SRY (sex determining region Y)-box 9
SPP1 secreted phosphoprotein 1
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
STC1 stanniocalcin 1
STX1A syntaxin 1A (brain)
TACSTD2 tumor-associated calcium signal transducer 2
THBS1 thrombospondin 1
TMEM47 transmembrane protein 47
VCAN versican
Funding