BRD-K50000283_PHA-767491_A375_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

106 genes differentially expressed following the BRD-K50000283_PHA-767491_A375_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACKR3 atypical chemokine receptor 3
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALDOC aldolase C, fructose-bisphosphate
ANGPTL2 angiopoietin-like 2
ASCL1 achaete-scute family bHLH transcription factor 1
ASS1 argininosuccinate synthase 1
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
BAALC brain and acute leukemia, cytoplasmic
BEX1 brain expressed, X-linked 1
CFB complement factor B
CHGB chromogranin B
CHL1 cell adhesion molecule L1-like
CLCA4 chloride channel accessory 4
CLIP3 CAP-GLY domain containing linker protein 3
DCN decorin
DHDDS dehydrodolichyl diphosphate synthase
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DNTT DNA nucleotidylexotransferase
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EMP1 epithelial membrane protein 1
GPM6B glycoprotein M6B
GREB1 growth regulation by estrogen in breast cancer 1
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IL13RA1 interleukin 13 receptor, alpha 1
IVNS1ABP influenza virus NS1A binding protein
KIF5C kinesin family member 5C
LOC100505650 uncharacterized LOC100505650
LTBP1 latent transforming growth factor beta binding protein 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOA monoamine oxidase A
MMP12 matrix metallopeptidase 12
MXRA5 matrix-remodelling associated 5
NCAM1 neural cell adhesion molecule 1
NGRN neugrin, neurite outgrowth associated
NRCAM neuronal cell adhesion molecule
PCP4 Purkinje cell protein 4
PDIA5 protein disulfide isomerase family A, member 5
PRR7 proline rich 7 (synaptic)
PTP4A3 protein tyrosine phosphatase type IVA, member 3
PXMP2 peroxisomal membrane protein 2, 22kDa
RBP1 retinol binding protein 1, cellular
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RET ret proto-oncogene
RHOBTB3 Rho-related BTB domain containing 3
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SORD sorbitol dehydrogenase
SOX4 SRY (sex determining region Y)-box 4
SPINK1 serine peptidase inhibitor, Kazal type 1
SPON1 spondin 1, extracellular matrix protein
SPON2 spondin 2, extracellular matrix protein
SQLE squalene epoxidase
SST somatostatin
STC1 stanniocalcin 1
STMN2 stathmin 2
STS steroid sulfatase (microsomal), isozyme S
TAPBPL TAP binding protein-like
TM9SF3 transmembrane 9 superfamily member 3
TST thiosulfate sulfurtransferase (rhodanese)
TUBB2A tubulin, beta 2A class IIa
VCAN versican
ZKSCAN1 zinc finger with KRAB and SCAN domains 1
ZNF423 zinc finger protein 423

decreased expression

Symbol Name
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA3 annexin A3
ANXA5 annexin A5
APOE apolipoprotein E
BACE2 beta-site APP-cleaving enzyme 2
BASP1 brain abundant, membrane attached signal protein 1
C1ORF116 chromosome 1 open reading frame 116
CNN3 calponin 3, acidic
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
CST7 cystatin F (leukocystatin)
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
EFNB2 ephrin-B2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EZR ezrin
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GNG11 guanine nucleotide binding protein (G protein), gamma 11
HDGFRP3 hepatoma-derived growth factor, related protein 3
HOXC6 homeobox C6
KRT17 keratin 17, type I
KRT6B keratin 6B, type II
KRT7 keratin 7, type II
LITAF lipopolysaccharide-induced TNF factor
MET MET proto-oncogene, receptor tyrosine kinase
MMP9 matrix metallopeptidase 9
MOK MOK protein kinase
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
NQO1 NAD(P)H dehydrogenase, quinone 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
RGS13 regulator of G-protein signaling 13
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SQSTM1 sequestosome 1
STAP1 signal transducing adaptor family member 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMEM2 transmembrane protein 2
VCAM1 vascular cell adhesion molecule 1
Funding