BRD-K50140147_NVP-TAE684_A375_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

289 genes differentially expressed following the BRD-K50140147_NVP-TAE684_A375_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AHNAK2 AHNAK nucleoprotein 2
AKR1C3 aldo-keto reductase family 1, member C3
ANKRD10 ankyrin repeat domain 10
ANXA4 annexin A4
AOX1 aldehyde oxidase 1
APOD apolipoprotein D
ARMCX1 armadillo repeat containing, X-linked 1
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BCL6 B-cell CLL/lymphoma 6
BEX4 brain expressed, X-linked 4
BTG1 B-cell translocation gene 1, anti-proliferative
C1RL complement component 1, r subcomponent-like
C3 complement component 3
CAMLG calcium modulating ligand
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCPG1 cell cycle progression 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CES2 carboxylesterase 2
CFB complement factor B
CPQ carboxypeptidase Q
CRYAB crystallin, alpha B
CTSK cathepsin K
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EFNA1 ephrin-A1
EPS8L2 EPS8-like 2
ERCC5 excision repair cross-complementation group 5
FADS1 fatty acid desaturase 1
FAM63A family with sequence similarity 63, member A
FAS Fas cell surface death receptor
FDXR ferredoxin reductase
FOXO4 forkhead box O4
GAS6 growth arrest-specific 6
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GDF15 growth differentiation factor 15
GOLGA8B golgin A8 family, member B
GPNMB glycoprotein (transmembrane) nmb
GPRASP1 G protein-coupled receptor associated sorting protein 1
GREM1 gremlin 1, DAN family BMP antagonist
GSN gelsolin
H2BFS H2B histone family, member S (pseudogene)
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HLA-E major histocompatibility complex, class I, E
HLA-F major histocompatibility complex, class I, F
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IER5 immediate early response 5
IFI6 interferon, alpha-inducible protein 6
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
ISG15 ISG15 ubiquitin-like modifier
ISG20 interferon stimulated exonuclease gene 20kDa
ITGA7 integrin, alpha 7
JUND jun D proto-oncogene
KIZ kizuna centrosomal protein
KLF5 Kruppel-like factor 5 (intestinal)
KLHL24 kelch-like family member 24
KRT23 keratin 23, type I
KYNU kynureninase
LDLR low density lipoprotein receptor
LITAF lipopolysaccharide-induced TNF factor
LXN latexin
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAN1A1 mannosidase, alpha, class 1A, member 1
MEIS1 Meis homeobox 1
METTL7A methyltransferase like 7A
MTSS1 metastasis suppressor 1
MVP major vault protein
MXD4 MAX dimerization protein 4
MXI1 MAX interactor 1, dimerization protein
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEU1 sialidase 1 (lysosomal sialidase)
NOV nephroblastoma overexpressed
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRCAM neuronal cell adhesion molecule
NUPR1 nuclear protein, transcriptional regulator, 1
OPTN optineurin
ORAI3 ORAI calcium release-activated calcium modulator 3
OSR2 odd-skipped related transciption factor 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PLCB4 phospholipase C, beta 4
PNRC1 proline-rich nuclear receptor coactivator 1
PROM1 prominin 1
PRUNE2 prune homolog 2 (Drosophila)
PYCARD PYD and CARD domain containing
QPCT glutaminyl-peptide cyclotransferase
RAB29 RAB29, member RAS oncogene family
RABAC1 Rab acceptor 1 (prenylated)
RPS27L ribosomal protein S27-like
RSRP1 arginine/serine-rich protein 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SIDT2 SID1 transmembrane family, member 2
SLC22A18 solute carrier family 22, member 18
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SOD2 superoxide dismutase 2, mitochondrial
SPATA20 spermatogenesis associated 20
SPON2 spondin 2, extracellular matrix protein
SQLE squalene epoxidase
SQSTM1 sequestosome 1
SSPN sarcospan
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SYBU syntabulin (syntaxin-interacting)
TOB1 transducer of ERBB2, 1
TP53I3 tumor protein p53 inducible protein 3
TPP1 tripeptidyl peptidase I
TRIM22 tripartite motif containing 22
TRPS1 trichorhinophalangeal syndrome I
TSC22D3 TSC22 domain family, member 3
VAT1 vesicle amine transport 1
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
WDTC1 WD and tetratricopeptide repeats 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)
ZFP36L2 ZFP36 ring finger protein-like 2
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ACOT7 acyl-CoA thioesterase 7
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
AURKB aurora kinase B
AUTS2 autism susceptibility candidate 2
BIRC5 baculoviral IAP repeat containing 5
BLM Bloom syndrome, RecQ helicase-like
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
CACYBP calcyclin binding protein
CBFB core-binding factor, beta subunit
CCNA2 cyclin A2
CCND1 cyclin D1
CCNE2 cyclin E2
CCNF cyclin F
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDCA3 cell division cycle associated 3
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CENPM centromere protein M
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHEK2 checkpoint kinase 2
CIT citron rho-interacting serine/threonine kinase
CKS1B CDC28 protein kinase regulatory subunit 1B
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
COL6A3 collagen, type VI, alpha 3
CSE1L CSE1 chromosome segregation 1-like (yeast)
DBF4 DBF4 zinc finger
DCK deoxycytidine kinase
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP6 dual specificity phosphatase 6
ECT2 epithelial cell transforming 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EXO1 exonuclease 1
EXOSC9 exosome component 9
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F3 coagulation factor III (thromboplastin, tissue factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM64A family with sequence similarity 64, member A
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTSE1 G-2 and S-phase expressed 1
HBB hemoglobin, beta
HES1 hes family bHLH transcription factor 1
HJURP Holliday junction recognition protein
HMGA2 high mobility group AT-hook 2
HMGB2 high mobility group box 2
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
IER2 immediate early response 2
IGFBP3 insulin-like growth factor binding protein 3
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF4A kinesin family member 4A
LMNB1 lamin B1
LMNB2 lamin B2
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP1 matrix metallopeptidase 1
MMP9 matrix metallopeptidase 9
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYO10 myosin X
NAV3 neuron navigator 3
NCAPD3 non-SMC condensin II complex, subunit D3
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NCAPH non-SMC condensin I complex, subunit H
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NEK2 NIMA-related kinase 2
NUSAP1 nucleolar and spindle associated protein 1
ODC1 ornithine decarboxylase 1
ORC6 origin recognition complex, subunit 6
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBK PDZ binding kinase
PFAS phosphoribosylformylglycinamidine synthase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLK4 polo-like kinase 4
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
RACGAP1 Rac GTPase activating protein 1
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RAD54B RAD54 homolog B (S. cerevisiae)
RANBP1 RAN binding protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RGS2 regulator of G-protein signaling 2
RNASEH2A ribonuclease H2, subunit A
RRM2 ribonucleotide reductase M2
SEPHS1 selenophosphate synthetase 1
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SPC25 SPC25, NDC80 kinetochore complex component
SRSF3 serine/arginine-rich splicing factor 3
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TACSTD2 tumor-associated calcium signal transducer 2
TIPIN TIMELESS interacting protein
TK1 thymidine kinase 1, soluble
TMPO thymopoietin
TMSB15A thymosin beta 15a
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM4 tropomyosin 4
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TSPAN13 tetraspanin 13
TTK TTK protein kinase
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
VRK1 vaccinia related kinase 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZNF22 zinc finger protein 22
ZWINT ZW10 interacting kinetochore protein
Funding