BRD-K50140147_NVP-TAE684_HA1E_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

218 genes differentially expressed following the BRD-K50140147_NVP-TAE684_HA1E_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ADGRG2 adhesion G protein-coupled receptor G2
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
AIM1 absent in melanoma 1
APOL3 apolipoprotein L, 3
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ATP2A3 ATPase, Ca++ transporting, ubiquitous
BAMBI BMP and activin membrane-bound inhibitor
BCL6 B-cell CLL/lymphoma 6
BIRC3 baculoviral IAP repeat containing 3
BMP2 bone morphogenetic protein 2
BST2 bone marrow stromal cell antigen 2
BTG1 B-cell translocation gene 1, anti-proliferative
C1S complement component 1, s subcomponent
C3 complement component 3
C8ORF4 chromosome 8 open reading frame 4
CBR3 carbonyl reductase 3
CCL2 chemokine (C-C motif) ligand 2
CCL5 chemokine (C-C motif) ligand 5
CCL8 chemokine (C-C motif) ligand 8
CCNG2 cyclin G2
CD24 CD24 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLU clusterin
CSRP1 cysteine and glycine-rich protein 1
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL6 chemokine (C-X-C motif) ligand 6
CXCL9 chemokine (C-X-C motif) ligand 9
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DPP4 dipeptidyl-peptidase 4
ECH1 enoyl CoA hydratase 1, peroxisomal
EFNA1 ephrin-A1
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
EMX2 empty spiracles homeobox 2
EPAS1 endothelial PAS domain protein 1
FABP4 fatty acid binding protein 4, adipocyte
FBLN1 fibulin 1
FTH1 ferritin, heavy polypeptide 1
GBP1 guanylate binding protein 1, interferon-inducible
GBP2 guanylate binding protein 2, interferon-inducible
GCH1 GTP cyclohydrolase 1
GOLGA8H golgin A8 family, member H
GRB7 growth factor receptor-bound protein 7
GSDMB gasdermin B
GSN gelsolin
H2BFS H2B histone family, member S (pseudogene)
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HLA-B major histocompatibility complex, class I, B
HLA-F major histocompatibility complex, class I, F
ICAM1 intercellular adhesion molecule 1
IDO1 indoleamine 2,3-dioxygenase 1
IFI27 interferon, alpha-inducible protein 27
IFI35 interferon-induced protein 35
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIH1 interferon induced with helicase C domain 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IFITM1 interferon induced transmembrane protein 1
INA internexin neuronal intermediate filament protein, alpha
IRF1 interferon regulatory factor 1
IRF7 interferon regulatory factor 7
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
ISG20 interferon stimulated exonuclease gene 20kDa
KIF5C kinesin family member 5C
LAMP3 lysosomal-associated membrane protein 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LITAF lipopolysaccharide-induced TNF factor
LOC100505650 uncharacterized LOC100505650
LTB lymphotoxin beta (TNF superfamily, member 3)
MICB MHC class I polypeptide-related sequence B
MX1 MX dynamin-like GTPase 1
MX2 MX dynamin-like GTPase 2
MYH11 myosin, heavy chain 11, smooth muscle
NEFH neurofilament, heavy polypeptide
NFIB nuclear factor I/B
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKG7 natural killer cell granule protein 7
NMI N-myc (and STAT) interactor
NNMT nicotinamide N-methyltransferase
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OASL 2'-5'-oligoadenylate synthetase-like
PARP12 poly (ADP-ribose) polymerase family, member 12
PAX8 paired box 8
PBX3 pre-B-cell leukemia homeobox 3
PCP4 Purkinje cell protein 4
PDGFD platelet derived growth factor D
PEG10 paternally expressed 10
PLSCR1 phospholipid scramblase 1
PPAP2B phosphatidic acid phosphatase type 2B
PPL periplakin
PRAME preferentially expressed antigen in melanoma
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRTN3 proteinase 3
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTPRO protein tyrosine phosphatase, receptor type, O
RAB27A RAB27A, member RAS oncogene family
RAB29 RAB29, member RAS oncogene family
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RSAD2 radical S-adenosyl methionine domain containing 2
RTN2 reticulon 2
RYR1 ryanodine receptor 1 (skeletal)
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC43A3 solute carrier family 43, member 3
SNN stannin
SOD2 superoxide dismutase 2, mitochondrial
SP110 SP110 nuclear body protein
STAT1 signal transducer and activator of transcription 1, 91kDa
STOM stomatin
SYNE2 spectrin repeat containing, nuclear envelope 2
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TAPBP TAP binding protein (tapasin)
TDRD7 tudor domain containing 7
TFPI2 tissue factor pathway inhibitor 2
THEMIS2 thymocyte selection associated family member 2
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIM14 tripartite motif containing 14
TRIM22 tripartite motif containing 22
UBA7 ubiquitin-like modifier activating enzyme 7
UBE2L6 ubiquitin-conjugating enzyme E2L 6
USP18 ubiquitin specific peptidase 18
VCAM1 vascular cell adhesion molecule 1
XAF1 XIAP associated factor 1
ZFPM2 zinc finger protein, FOG family member 2

decreased expression

Symbol Name
AK4 adenylate kinase 4
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BZW1 basic leucine zipper and W2 domains 1
CCDC86 coiled-coil domain containing 86
CCND1 cyclin D1
COL1A1 collagen, type I, alpha 1
COL5A1 collagen, type V, alpha 1
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CRLF1 cytokine receptor-like factor 1
DACT1 dishevelled-binding antagonist of beta-catenin 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
ELL2 elongation factor, RNA polymerase II, 2
EPHB2 EPH receptor B2
F3 coagulation factor III (thromboplastin, tissue factor)
FABP7 fatty acid binding protein 7, brain
FAM171A1 family with sequence similarity 171, member A1
FAT1 FAT atypical cadherin 1
FOSL1 FOS-like antigen 1
FOXD1 forkhead box D1
GADD45B growth arrest and DNA-damage-inducible, beta
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HES1 hes family bHLH transcription factor 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGFBP3 insulin-like growth factor binding protein 3
INHBA inhibin, beta A
ITGA6 integrin, alpha 6
JCHAIN joining chain of multimeric IgA and IgM
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KLF10 Kruppel-like factor 10
LGALS3 lectin, galactoside-binding, soluble, 3
LOX lysyl oxidase
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MINA MYC induced nuclear antigen
MOK MOK protein kinase
MYC v-myc avian myelocytomatosis viral oncogene homolog
OAT ornithine aminotransferase
PDLIM2 PDZ and LIM domain 2 (mystique)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PRSS23 protease, serine, 23
PSPH phosphoserine phosphatase
PYCR1 pyrroline-5-carboxylate reductase 1
RGS4 regulator of G-protein signaling 4
RPN1 ribophorin I
RPP40 ribonuclease P/MRP 40kDa subunit
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SUB1 SUB1 homolog (S. cerevisiae)
TGFBI transforming growth factor, beta-induced, 68kDa
THBS1 thrombospondin 1
TMED2 transmembrane emp24 domain trafficking protein 2
TMEM45A transmembrane protein 45A
TRAM2 translocation associated membrane protein 2
TUBB6 tubulin, beta 6 class V
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
VCAN versican
WDR12 WD repeat domain 12
WNT5B wingless-type MMTV integration site family, member 5B
Funding