BRD-K50140147_NVP-TAE684_HME1_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

158 genes differentially expressed following the BRD-K50140147_NVP-TAE684_HME1_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACTN1 actinin, alpha 1
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ANXA1 annexin A1
AOX1 aldehyde oxidase 1
ASS1 argininosuccinate synthase 1
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCL6 B-cell CLL/lymphoma 6
BHLHE41 basic helix-loop-helix family, member e41
BTG1 B-cell translocation gene 1, anti-proliferative
C1S complement component 1, s subcomponent
C6ORF48 chromosome 6 open reading frame 48
CAMLG calcium modulating ligand
CEMIP cell migration inducing protein, hyaluronan binding
CTGF connective tissue growth factor
CTSB cathepsin B
CTSK cathepsin K
CYR61 cysteine-rich, angiogenic inducer, 61
DFNA5 deafness, autosomal dominant 5
DSE dermatan sulfate epimerase
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EMP1 epithelial membrane protein 1
EMX2 empty spiracles homeobox 2
ESR1 estrogen receptor 1
F13A1 coagulation factor XIII, A1 polypeptide
FBN2 fibrillin 2
FCGBP Fc fragment of IgG binding protein
GOLT1B golgi transport 1B
GPNMB glycoprotein (transmembrane) nmb
GREM1 gremlin 1, DAN family BMP antagonist
GRN granulin
HBP1 HMG-box transcription factor 1
HDAC9 histone deacetylase 9
HIST1H2BD histone cluster 1, H2bd
HIST3H2A histone cluster 3, H2a
HLA-E major histocompatibility complex, class I, E
HOXA10 homeobox A10
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP7 insulin-like growth factor binding protein 7
IRS2 insulin receptor substrate 2
ITGAV integrin, alpha V
ITM2B integral membrane protein 2B
LAMA3 laminin, alpha 3
LAMC2 laminin, gamma 2
LOC100505650 uncharacterized LOC100505650
LTBP2 latent transforming growth factor beta binding protein 2
MAN1A1 mannosidase, alpha, class 1A, member 1
MMP7 matrix metallopeptidase 7
MXRA5 matrix-remodelling associated 5
NDRG1 N-myc downstream regulated 1
NONO non-POU domain containing, octamer-binding
NT5E 5'-nucleotidase, ecto (CD73)
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAX8 paired box 8
PLAGL1 pleiomorphic adenoma gene-like 1
PLEKHA5 pleckstrin homology domain containing, family A member 5
PSAP prosaposin
PTGER4 prostaglandin E receptor 4 (subtype EP4)
QARS glutaminyl-tRNA synthetase
RNASET2 ribonuclease T2
RND3 Rho family GTPase 3
SAT1 spermidine/spermine N1-acetyltransferase 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERINC1 serine incorporator 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SPATA20 spermatogenesis associated 20
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SQSTM1 sequestosome 1
SSPN sarcospan
TFPI2 tissue factor pathway inhibitor 2
TKT transketolase
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPP1 tripeptidyl peptidase I
TSC22D3 TSC22 domain family, member 3
TUBA1A tubulin, alpha 1a
VAT1 vesicle amine transport 1
VAV3 vav 3 guanine nucleotide exchange factor

decreased expression

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
ACTA1 actin, alpha 1, skeletal muscle
AGR2 anterior gradient 2
AURKA aurora kinase A
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CDC42 cell division cycle 42
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CKM creatine kinase, muscle
DBF4 DBF4 zinc finger
DCLK1 doublecortin-like kinase 1
DHCR7 7-dehydrocholesterol reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DLK1 delta-like 1 homolog (Drosophila)
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
ENO3 enolase 3 (beta, muscle)
EPCAM epithelial cell adhesion molecule
FABP7 fatty acid binding protein 7, brain
FASN fatty acid synthase
GYG1 glycogenin 1
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDI1 isopentenyl-diphosphate delta isomerase 1
IGL immunoglobulin lambda locus
INSIG1 insulin induced gene 1
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF5B kinesin family member 5B
LIMCH1 LIM and calponin homology domains 1
LPL lipoprotein lipase
MALL mal, T-cell differentiation protein-like
MAP7 microtubule-associated protein 7
MB myoglobin
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MSMO1 methylsterol monooxygenase 1
NEB nebulin
ODC1 ornithine decarboxylase 1
PBK PDZ binding kinase
PLK1 polo-like kinase 1
PLS1 plastin 1
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)
POSTN periostin, osteoblast specific factor
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
QDPR quinoid dihydropteridine reductase
RAD51C RAD51 paralog C
RANBP1 RAN binding protein 1
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SRM spermidine synthase
TACC3 transforming, acidic coiled-coil containing protein 3
THAP11 THAP domain containing 11
THBS4 thrombospondin 4
TNNC1 troponin C type 1 (slow)
TNNI2 troponin I type 2 (skeletal, fast)
TOX3 TOX high mobility group box family member 3
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TSPAN13 tetraspanin 13
TSPAN8 tetraspanin 8
TTN titin
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2S ubiquitin-conjugating enzyme E2S
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)
ZBTB18 zinc finger and BTB domain containing 18
Funding