BRD-K50140147_NVP-TAE684_HT29_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

231 genes differentially expressed following the BRD-K50140147_NVP-TAE684_HT29_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADGRF5 adhesion G protein-coupled receptor F5
AGR2 anterior gradient 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANXA4 annexin A4
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATP9A ATPase, class II, type 9A
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BCAS1 breast carcinoma amplified sequence 1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
CCNG1 cyclin G1
CCNG2 cyclin G2
CCNI cyclin I
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHPT1 choline phosphotransferase 1
CLIC3 chloride intracellular channel 3
CST3 cystatin C
CTSA cathepsin A
CXCL14 chemokine (C-X-C motif) ligand 14
CYFIP2 cytoplasmic FMR1 interacting protein 2
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DAPK1 death-associated protein kinase 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DYNLRB1 dynein, light chain, roadblock-type 1
DYNLT3 dynein, light chain, Tctex-type 3
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FAM134B family with sequence similarity 134, member B
FOLR1 folate receptor 1 (adult)
FOXO4 forkhead box O4
FXYD2 FXYD domain containing ion transport regulator 2
GABARAPL2 GABA(A) receptor-associated protein-like 2
GOLGA8A golgin A8 family, member A
GOLGA8H golgin A8 family, member H
GPX3 glutathione peroxidase 3
GSN gelsolin
HBP1 HMG-box transcription factor 1
HIST1H2BD histone cluster 1, H2bd
HLA-E major histocompatibility complex, class I, E
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IDS iduronate 2-sulfatase
IGBP1 immunoglobulin (CD79A) binding protein 1
JUN jun proto-oncogene
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KLHL24 kelch-like family member 24
KRT18 keratin 18, type I
KRT20 keratin 20, type I
LCN2 lipocalin 2
LEPROT leptin receptor overlapping transcript
LRP10 low density lipoprotein receptor-related protein 10
LY75 lymphocyte antigen 75
MACF1 microtubule-actin crosslinking factor 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAOA monoamine oxidase A
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MARCKSL1 MARCKS-like 1
MET MET proto-oncogene, receptor tyrosine kinase
MMP7 matrix metallopeptidase 7
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MUC13 mucin 13, cell surface associated
MUC2 mucin 2, oligomeric mucus/gel-forming
MVP major vault protein
NNMT nicotinamide N-methyltransferase
NPDC1 neural proliferation, differentiation and control, 1
NUPR1 nuclear protein, transcriptional regulator, 1
ORAI3 ORAI calcium release-activated calcium modulator 3
PAWR PRKC, apoptosis, WT1, regulator
PCCA propionyl CoA carboxylase, alpha polypeptide
PDGFC platelet derived growth factor C
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PDZK1IP1 PDZK1 interacting protein 1
PGLS 6-phosphogluconolactonase
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PINK1 PTEN induced putative kinase 1
PKP4 plakophilin 4
PLA2G16 phospholipase A2, group XVI
PLCB4 phospholipase C, beta 4
PNRC1 proline-rich nuclear receptor coactivator 1
POF1B premature ovarian failure, 1B
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PROM1 prominin 1
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PYCARD PYD and CARD domain containing
QPCT glutaminyl-peptide cyclotransferase
RAB40B RAB40B, member RAS oncogene family
RABAC1 Rab acceptor 1 (prenylated)
RAP1GAP RAP1 GTPase activating protein
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
REG1A regenerating islet-derived 1 alpha
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPS4Y1 ribosomal protein S4, Y-linked 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPP1 selenoprotein P, plasma, 1
SERF2 small EDRK-rich factor 2
SFXN3 sideroflexin 3
SIDT2 SID1 transmembrane family, member 2
SLC22A18 solute carrier family 22, member 18
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC44A4 solute carrier family 44, member 4
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SOS2 son of sevenless homolog 2 (Drosophila)
SOX4 SRY (sex determining region Y)-box 4
SPINK4 serine peptidase inhibitor, Kazal type 4
STXBP1 syntaxin binding protein 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIMP1 TIMP metallopeptidase inhibitor 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOX3 TOX high mobility group box family member 3
TPM1 tropomyosin 1 (alpha)
TPP1 tripeptidyl peptidase I
TRIM8 tripartite motif containing 8
TSC22D3 TSC22 domain family, member 3
TSPAN1 tetraspanin 1
TSPAN31 tetraspanin 31
TSPAN8 tetraspanin 8
TUBA1A tubulin, alpha 1a
TXNIP thioredoxin interacting protein
VAT1 vesicle amine transport 1
VIM vimentin
WDTC1 WD and tetratricopeptide repeats 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ATAD2 ATPase family, AAA domain containing 2
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BIRC5 baculoviral IAP repeat containing 5
BTG3 BTG family, member 3
C1QBP complement component 1, q subcomponent binding protein
CA2 carbonic anhydrase II
CCNA2 cyclin A2
CCNF cyclin F
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CENPN centromere protein N
CENPU centromere protein U
CHEK2 checkpoint kinase 2
COL5A1 collagen, type V, alpha 1
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
CSE1L CSE1 chromosome segregation 1-like (yeast)
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
DBF4 DBF4 zinc finger
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DLK1 delta-like 1 homolog (Drosophila)
DPT dermatopontin
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP5 dual specificity phosphatase 5
EIF4A1 eukaryotic translation initiation factor 4A1
EIF5A eukaryotic translation initiation factor 5A
ESR1 estrogen receptor 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM129A family with sequence similarity 129, member A
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
GAL galanin/GMAP prepropeptide
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
H2AFX H2A histone family, member X
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGB2 high mobility group box 2
HSPA14 heat shock 70kDa protein 14
IGHM immunoglobulin heavy constant mu
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LTF lactotransferrin
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NUP210 nucleoporin 210kDa
OAT ornithine aminotransferase
ODC1 ornithine decarboxylase 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBK PDZ binding kinase
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PFN2 profilin 2
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PON3 paraoxonase 3
PPAT phosphoribosyl pyrophosphate amidotransferase
PPIF peptidylprolyl isomerase F
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRC1 protein regulator of cytokinesis 1
PRMT1 protein arginine methyltransferase 1
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RAD51 RAD51 recombinase
RANBP1 RAN binding protein 1
RDX radixin
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RRM2 ribonucleotide reductase M2
SLC43A3 solute carrier family 43, member 3
SMC1A structural maintenance of chromosomes 1A
SPON1 spondin 1, extracellular matrix protein
SRM spermidine synthase
SRSF7 serine/arginine-rich splicing factor 7
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFRC transferrin receptor
TK1 thymidine kinase 1, soluble
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIP13 thyroid hormone receptor interactor 13
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UCHL5 ubiquitin carboxyl-terminal hydrolase L5
VRK1 vaccinia related kinase 1
XIST X inactive specific transcript (non-protein coding)
Funding