BRD-K50140147_NVP-TAE684_MCF10A_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

75 genes differentially expressed following the BRD-K50140147_NVP-TAE684_MCF10A_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM10 ADAM metallopeptidase domain 10
ANPEP alanyl (membrane) aminopeptidase
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BEX1 brain expressed, X-linked 1
CBR3 carbonyl reductase 3
CCNG2 cyclin G2
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFB complement factor B
CLDN10 claudin 10
CTSE cathepsin E
DEFB1 defensin, beta 1
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
FKBP5 FK506 binding protein 5
GLUL glutamate-ammonia ligase
H1FX H1 histone family, member X
LCN2 lipocalin 2
LDLR low density lipoprotein receptor
MB myoglobin
MEIS2 Meis homeobox 2
METTL7A methyltransferase like 7A
MTSS1 metastasis suppressor 1
MUC4 mucin 4, cell surface associated
MUC5B mucin 5B, oligomeric mucus/gel-forming
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEFH neurofilament, heavy polypeptide
NFIL3 nuclear factor, interleukin 3 regulated
NPTX2 neuronal pentraxin II
PADI2 peptidyl arginine deiminase, type II
PDZK1IP1 PDZK1 interacting protein 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PMP22 peripheral myelin protein 22
PROM1 prominin 1
RGS2 regulator of G-protein signaling 2
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A14 S100 calcium binding protein A14
S100P S100 calcium binding protein P
SFRP1 secreted frizzled-related protein 1
SNAP25 synaptosomal-associated protein, 25kDa
SYNGR3 synaptogyrin 3
TFF1 trefoil factor 1
TLE4 transducin-like enhancer of split 4
TNNT1 troponin T type 1 (skeletal, slow)
TSC22D3 TSC22 domain family, member 3

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
CCND1 cyclin D1
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
E2F5 E2F transcription factor 5, p130-binding
EGR2 early growth response 2
EREG epiregulin
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GLS glutaminase
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
IL1B interleukin 1, beta
INHBA inhibin, beta A
ISG15 ISG15 ubiquitin-like modifier
JUN jun proto-oncogene
MET MET proto-oncogene, receptor tyrosine kinase
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLAU plasminogen activator, urokinase
PTGDS prostaglandin D2 synthase 21kDa (brain)
SATB1 SATB homeobox 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP4 secreted frizzled-related protein 4
SNRPE small nuclear ribonucleoprotein polypeptide E
SPAG4 sperm associated antigen 4
SRSF11 serine/arginine-rich splicing factor 11
STAT1 signal transducer and activator of transcription 1, 91kDa
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TPD52L1 tumor protein D52-like 1
XIST X inactive specific transcript (non-protein coding)
Funding