BRD-K50140147_NVP-TAE684_MDAMB231_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

134 genes differentially expressed following the BRD-K50140147_NVP-TAE684_MDAMB231_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AHR aryl hydrocarbon receptor
ALDOC aldolase C, fructose-bisphosphate
ATF3 activating transcription factor 3
ATHL1 ATH1, acid trehalase-like 1 (yeast)
BBX bobby sox homolog (Drosophila)
BEX1 brain expressed, X-linked 1
BHLHE41 basic helix-loop-helix family, member e41
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BST2 bone marrow stromal cell antigen 2
C6ORF62 chromosome 6 open reading frame 62
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CFI complement factor I
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CXCL8 chemokine (C-X-C motif) ligand 8
DAXX death-domain associated protein
DDIT4 DNA-damage-inducible transcript 4
DUSP4 dual specificity phosphatase 4
ELF1 E74-like factor 1 (ets domain transcription factor)
ETV1 ets variant 1
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FAM13A family with sequence similarity 13, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FILIP1L filamin A interacting protein 1-like
FOXO4 forkhead box O4
GBP2 guanylate binding protein 2, interferon-inducible
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GOLGA8H golgin A8 family, member H
HIST1H2BK histone cluster 1, H2bk
HLA-E major histocompatibility complex, class I, E
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
ICAM1 intercellular adhesion molecule 1
KYNU kynureninase
LDLR low density lipoprotein receptor
LXN latexin
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MEIS1 Meis homeobox 1
MSMO1 methylsterol monooxygenase 1
MXI1 MAX interactor 1, dimerization protein
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
ORAI3 ORAI calcium release-activated calcium modulator 3
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PON2 paraoxonase 2
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SFXN3 sideroflexin 3
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TNS3 tensin 3
TUBA1A tubulin, alpha 1a
TXNIP thioredoxin interacting protein
VAMP8 vesicle-associated membrane protein 8

decreased expression

Symbol Name
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A
AURKB aurora kinase B
AUTS2 autism susceptibility candidate 2
BIN1 bridging integrator 1
BZW2 basic leucine zipper and W2 domains 2
CA2 carbonic anhydrase II
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CCNF cyclin F
CD24 CD24 molecule
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CENPU centromere protein U
COQ2 coenzyme Q2 4-hydroxybenzoate polyprenyltransferase
CXCL13 chemokine (C-X-C motif) ligand 13
DBF4 DBF4 zinc finger
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EMP1 epithelial membrane protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GMNN geminin, DNA replication inhibitor
HMGB2 high mobility group box 2
IL13RA2 interleukin 13 receptor, alpha 2
IL1R2 interleukin 1 receptor, type II
KRT15 keratin 15, type I
KRT5 keratin 5, type II
LEFTY1 left-right determination factor 1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MALL mal, T-cell differentiation protein-like
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MMP12 matrix metallopeptidase 12
MRPS2 mitochondrial ribosomal protein S2
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NPY neuropeptide Y
NRG1 neuregulin 1
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
PENK proenkephalin
PLAC8 placenta-specific 8
PLXNA2 plexin A2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PRIM1 primase, DNA, polypeptide 1 (49kDa)
RAD51AP1 RAD51 associated protein 1
RANBP1 RAN binding protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RRM2 ribonucleotide reductase M2
RTN1 reticulon 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SNAP25 synaptosomal-associated protein, 25kDa
SPP1 secreted phosphoprotein 1
SRSF7 serine/arginine-rich splicing factor 7
STEAP1 six transmembrane epithelial antigen of the prostate 1
STMN2 stathmin 2
TAC1 tachykinin, precursor 1
TEAD4 TEA domain family member 4
TMPO thymopoietin
UBE2C ubiquitin-conjugating enzyme E2C
USP1 ubiquitin specific peptidase 1
WHSC1 Wolf-Hirschhorn syndrome candidate 1
Funding