BRD-K50140147_NVP-TAE684_PC3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

93 genes differentially expressed following the BRD-K50140147_NVP-TAE684_PC3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
AGR2 anterior gradient 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
AQP1 aquaporin 1 (Colton blood group)
ARL4A ADP-ribosylation factor-like 4A
ATP9A ATPase, class II, type 9A
CCND2 cyclin D2
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD59 CD59 molecule, complement regulatory protein
CDH17 cadherin 17, LI cadherin (liver-intestine)
CDKN2A cyclin-dependent kinase inhibitor 2A
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DHCR7 7-dehydrocholesterol reductase
DSP desmoplakin
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EFNB2 ephrin-B2
ERBB3 erb-b2 receptor tyrosine kinase 3
ETV1 ets variant 1
F5 coagulation factor V (proaccelerin, labile factor)
FGG fibrinogen gamma chain
FXYD3 FXYD domain containing ion transport regulator 3
G0S2 G0/G1 switch 2
GBP2 guanylate binding protein 2, interferon-inducible
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HIST2H2BE histone cluster 2, H2be
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
ITGB4 integrin, beta 4
KRT18 keratin 18, type I
KRT19 keratin 19, type I
LDLR low density lipoprotein receptor
LGALS3 lectin, galactoside-binding, soluble, 3
LXN latexin
MYO6 myosin VI
NDRG1 N-myc downstream regulated 1
NELL2 NEL-like 2 (chicken)
NTS neurotensin
PCDH9 protocadherin 9
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PRSS2 protease, serine, 2 (trypsin 2)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS2 regulator of G-protein signaling 2
S100P S100 calcium binding protein P
SCGB2A2 secretoglobin, family 2A, member 2
SFRP1 secreted frizzled-related protein 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SNX13 sorting nexin 13
SOX4 SRY (sex determining region Y)-box 4
SPDEF SAM pointed domain containing ETS transcription factor
STK26 serine/threonine protein kinase 26
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIMP1 TIMP metallopeptidase inhibitor 1
TM4SF1 transmembrane 4 L six family member 1
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TPD52L1 tumor protein D52-like 1
TSPAN13 tetraspanin 13
TSPAN8 tetraspanin 8

decreased expression

Symbol Name
AXL AXL receptor tyrosine kinase
CIT citron rho-interacting serine/threonine kinase
CORO1A coronin, actin binding protein, 1A
CYB5A cytochrome b5 type A (microsomal)
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GOLM1 golgi membrane protein 1
HBB hemoglobin, beta
IGFBP3 insulin-like growth factor binding protein 3
IL13RA2 interleukin 13 receptor, alpha 2
MN1 meningioma (disrupted in balanced translocation) 1
MYBPC1 myosin binding protein C, slow type
NCAPG2 non-SMC condensin II complex, subunit G2
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NPTX2 neuronal pentraxin II
POPDC3 popeye domain containing 3
RAD23B RAD23 homolog B (S. cerevisiae)
RAD51AP1 RAD51 associated protein 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SNN stannin
SORBS2 sorbin and SH3 domain containing 2
STK10 serine/threonine kinase 10
TXNDC9 thioredoxin domain containing 9
Funding