BRD-K50168500_canertinib_HME1_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

211 genes differentially expressed following the BRD-K50168500_canertinib_HME1_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
AHNAK2 AHNAK nucleoprotein 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ALDOC aldolase C, fructose-bisphosphate
ANGPT1 angiopoietin 1
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BLVRB biliverdin reductase B
BPIFA1 BPI fold containing family A, member 1
BST2 bone marrow stromal cell antigen 2
BTG1 B-cell translocation gene 1, anti-proliferative
C1R complement component 1, r subcomponent
C1RL complement component 1, r subcomponent-like
C1S complement component 1, s subcomponent
C6ORF48 chromosome 6 open reading frame 48
CAT catalase
CBS cystathionine-beta-synthase
CCPG1 cell cycle progression 1
CDH3 cadherin 3, type 1, P-cadherin (placental)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CFB complement factor B
CFD complement factor D (adipsin)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLU clusterin
COL18A1 collagen, type XVIII, alpha 1
CREG1 cellular repressor of E1A-stimulated genes 1
CRYAB crystallin, alpha B
CTSA cathepsin A
CTSD cathepsin D
CXADR coxsackie virus and adenovirus receptor
DDAH2 dimethylarginine dimethylaminohydrolase 2
DLK1 delta-like 1 homolog (Drosophila)
EPB41L1 erythrocyte membrane protein band 4.1-like 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERP29 endoplasmic reticulum protein 29
FBLN1 fibulin 1
FMO2 flavin containing monooxygenase 2 (non-functional)
FOLR1 folate receptor 1 (adult)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FTH1 ferritin, heavy polypeptide 1
GAA glucosidase, alpha; acid
GBP2 guanylate binding protein 2, interferon-inducible
GCLC glutamate-cysteine ligase, catalytic subunit
GDF15 growth differentiation factor 15
GJA1 gap junction protein, alpha 1, 43kDa
GPNMB glycoprotein (transmembrane) nmb
GPX4 glutathione peroxidase 4
HMOX1 heme oxygenase 1
HOXA5 homeobox A5
HSPB1 heat shock 27kDa protein 1
HSPB8 heat shock 22kDa protein 8
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGF1R insulin-like growth factor 1 receptor
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ISYNA1 inositol-3-phosphate synthase 1
JAG2 jagged 2
KAZN kazrin, periplakin interacting protein
LAMP2 lysosomal-associated membrane protein 2
LEPROT leptin receptor overlapping transcript
LOC100505650 uncharacterized LOC100505650
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MEIS2 Meis homeobox 2
METTL7A methyltransferase like 7A
MFGE8 milk fat globule-EGF factor 8 protein
MTA1 metastasis associated 1
MX2 MX dynamin-like GTPase 2
MXI1 MAX interactor 1, dimerization protein
NAV2 neuron navigator 2
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEU1 sialidase 1 (lysosomal sialidase)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NNMT nicotinamide N-methyltransferase
NQO1 NAD(P)H dehydrogenase, quinone 1
NUPR1 nuclear protein, transcriptional regulator, 1
OLFML2A olfactomedin-like 2A
ORAI3 ORAI calcium release-activated calcium modulator 3
PERP PERP, TP53 apoptosis effector
PHGDH phosphoglycerate dehydrogenase
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLD3 phospholipase D family, member 3
PLIN2 perilipin 2
PLK2 polo-like kinase 2
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPL periplakin
PRDX2 peroxiredoxin 2
PROM1 prominin 1
PRUNE2 prune homolog 2 (Drosophila)
PSAP prosaposin
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RHOB ras homolog family member B
RNASET2 ribonuclease T2
SECTM1 secreted and transmembrane 1
SEPP1 selenoprotein P, plasma, 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFN stratifin
SIDT2 SID1 transmembrane family, member 2
SLPI secretory leukocyte peptidase inhibitor
SPATA20 spermatogenesis associated 20
SQSTM1 sequestosome 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TACSTD2 tumor-associated calcium signal transducer 2
TMEM45A transmembrane protein 45A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNPO1 transportin 1
TP53 tumor protein p53
TPD52L1 tumor protein D52-like 1
TPP1 tripeptidyl peptidase I
TRA2A transformer 2 alpha homolog (Drosophila)
TRAPPC6A trafficking protein particle complex 6A
TRIM22 tripartite motif containing 22
TSC22D3 TSC22 domain family, member 3
TXNRD1 thioredoxin reductase 1
UBA7 ubiquitin-like modifier activating enzyme 7
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAT1 vesicle amine transport 1
XAF1 XIAP associated factor 1
ZNF292 zinc finger protein 292
ZNF395 zinc finger protein 395
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACOT9 acyl-CoA thioesterase 9
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA3 annexin A3
AOC3 amine oxidase, copper containing 3
AREG amphiregulin
BMP2 bone morphogenetic protein 2
C3ORF14 chromosome 3 open reading frame 14
CCL19 chemokine (C-C motif) ligand 19
CCND1 cyclin D1
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CNN3 calponin 3, acidic
CPM carboxypeptidase M
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL5 chemokine (C-X-C motif) ligand 5
DOCK4 dedicator of cytokinesis 4
DUSP6 dual specificity phosphatase 6
EDNRA endothelin receptor type A
EGR1 early growth response 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FHL1 four and a half LIM domains 1
G0S2 G0/G1 switch 2
GAL galanin/GMAP prepropeptide
GREM1 gremlin 1, DAN family BMP antagonist
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IDI1 isopentenyl-diphosphate delta isomerase 1
IER3 immediate early response 3
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL7R interleukin 7 receptor
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
ITGA6 integrin, alpha 6
ITGB5 integrin, beta 5
JCHAIN joining chain of multimeric IgA and IgM
JMJD6 jumonji domain containing 6
KCTD12 potassium channel tetramerization domain containing 12
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LPAR1 lysophosphatidic acid receptor 1
LRRC59 leucine rich repeat containing 59
LTF lactotransferrin
MALL mal, T-cell differentiation protein-like
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MARCKS myristoylated alanine-rich protein kinase C substrate
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MMP9 matrix metallopeptidase 9
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MSMO1 methylsterol monooxygenase 1
MXRA7 matrix-remodelling associated 7
NT5E 5'-nucleotidase, ecto (CD73)
PDE4B phosphodiesterase 4B, cAMP-specific
PDLIM5 PDZ and LIM domain 5
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PMEPA1 prostate transmembrane protein, androgen induced 1
PPID peptidylprolyl isomerase D
PRKCH protein kinase C, eta
PRSS3 protease, serine, 3
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RFTN1 raftlin, lipid raft linker 1
S100A12 S100 calcium binding protein A12
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SMAGP small cell adhesion glycoprotein
SQLE squalene epoxidase
SRI sorcin
STEAP1 six transmembrane epithelial antigen of the prostate 1
STK17A serine/threonine kinase 17a
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TOX3 TOX high mobility group box family member 3
TRAPPC4 trafficking protein particle complex 4
TSPAN13 tetraspanin 13
TSPAN8 tetraspanin 8
TUBB2A tubulin, beta 2A class IIa
TUBB4B tubulin, beta 4B class IVb
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
VEGFC vascular endothelial growth factor C
Funding