BRD-K50168500_canertinib_MCF10A_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

165 genes differentially expressed following the BRD-K50168500_canertinib_MCF10A_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADCY1 adenylate cyclase 1 (brain)
ADD3 adducin 3 (gamma)
ADGRG2 adhesion G protein-coupled receptor G2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
BEX1 brain expressed, X-linked 1
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CFD complement factor D (adipsin)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CPVL carboxypeptidase, vitellogenic-like
CRIP1 cysteine-rich protein 1 (intestinal)
CRYAB crystallin, alpha B
CST3 cystatin C
CTH cystathionine gamma-lyase
CXCL12 chemokine (C-X-C motif) ligand 12
FGFR3 fibroblast growth factor receptor 3
GLUL glutamate-ammonia ligase
H1FX H1 histone family, member X
HAUS4 HAUS augmin-like complex, subunit 4
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPB8 heat shock 22kDa protein 8
IFI44L interferon-induced protein 44-like
IGFBP5 insulin-like growth factor binding protein 5
IGKV4-1 immunoglobulin kappa variable 4-1
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8
KLF4 Kruppel-like factor 4 (gut)
KRT13 keratin 13, type I
KRT19 keratin 19, type I
KRT5 keratin 5, type II
LY6E lymphocyte antigen 6 complex, locus E
MAOA monoamine oxidase A
METTL7A methyltransferase like 7A
MSRA methionine sulfoxide reductase A
MYLIP myosin regulatory light chain interacting protein
NEFL neurofilament, light polypeptide
NPTX2 neuronal pentraxin II
NUPR1 nuclear protein, transcriptional regulator, 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PIR pirin (iron-binding nuclear protein)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RELN reelin
RPS4Y1 ribosomal protein S4, Y-linked 1
SDC2 syndecan 2
SIDT2 SID1 transmembrane family, member 2
SYT1 synaptotagmin I
TCF4 transcription factor 4
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSC22D3 TSC22 domain family, member 3
TUBA1A tubulin, alpha 1a
VAV3 vav 3 guanine nucleotide exchange factor
VCAN versican
VLDLR very low density lipoprotein receptor
VSNL1 visinin-like 1
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1
ZMIZ1 zinc finger, MIZ-type containing 1

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AMIGO2 adhesion molecule with Ig-like domain 2
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARL4C ADP-ribosylation factor-like 4C
BCL2A1 BCL2-related protein A1
BHLHE40 basic helix-loop-helix family, member e40
BIK BCL2-interacting killer (apoptosis-inducing)
BMP2 bone morphogenetic protein 2
C1ORF106 chromosome 1 open reading frame 106
CCDC86 coiled-coil domain containing 86
CCL20 chemokine (C-C motif) ligand 20
CCND1 cyclin D1
CD24 CD24 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL4A2 collagen, type IV, alpha 2
CTGF connective tissue growth factor
CTSS cathepsin S
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHA2 EPH receptor A2
EREG epiregulin
ETV1 ets variant 1
EVI2A ecotropic viral integration site 2A
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FBP1 fructose-1,6-bisphosphatase 1
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GBP1 guanylate binding protein 1, interferon-inducible
GEM GTP binding protein overexpressed in skeletal muscle
GOLM1 golgi membrane protein 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HMGA2 high mobility group AT-hook 2
IER2 immediate early response 2
IER3 immediate early response 3
IFI16 interferon, gamma-inducible protein 16
IL13RA2 interleukin 13 receptor, alpha 2
IL1B interleukin 1, beta
IL32 interleukin 32
IL4R interleukin 4 receptor
ITGA6 integrin, alpha 6
JMJD6 jumonji domain containing 6
LAMC2 laminin, gamma 2
LIF leukemia inhibitory factor
LTF lactotransferrin
MGLL monoglyceride lipase
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYOF myoferlin
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
OSBPL10 oxysterol binding protein-like 10
PAM peptidylglycine alpha-amidating monooxygenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAUR plasminogen activator, urokinase receptor
PLEK2 pleckstrin 2
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTRF polymerase I and transcript release factor
REEP5 receptor accessory protein 5
RGS13 regulator of G-protein signaling 13
RPIA ribose 5-phosphate isomerase A
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFTPB surfactant protein B
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX9 SRY (sex determining region Y)-box 9
SPON1 spondin 1, extracellular matrix protein
STC1 stanniocalcin 1
STK17A serine/threonine kinase 17a
STX1A syntaxin 1A (brain)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TMEM158 transmembrane protein 158 (gene/pseudogene)
TPD52 tumor protein D52
TPM4 tropomyosin 4
TSPAN8 tetraspanin 8
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF395 zinc finger protein 395
Funding