BRD-K50311478_Na-Tosyl-Phe Chloromethyl Ketone_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

71 genes differentially expressed following the BRD-K50311478_Na-Tosyl-Phe Chloromethyl Ketone_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ASPH aspartate beta-hydroxylase
ATF3 activating transcription factor 3
CCND2 cyclin D2
CD24 CD24 molecule
CDA cytidine deaminase
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CRABP2 cellular retinoic acid binding protein 2
EMC2 ER membrane protein complex subunit 2
GCLM glutamate-cysteine ligase, modifier subunit
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HOXB6 homeobox B6
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IGFBP5 insulin-like growth factor binding protein 5
ITM2A integral membrane protein 2A
LTF lactotransferrin
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MDK midkine (neurite growth-promoting factor 2)
MMP12 matrix metallopeptidase 12
NQO2 NAD(P)H dehydrogenase, quinone 2
PCDH9 protocadherin 9
PCSK5 proprotein convertase subtilisin/kexin type 5
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
RGS1 regulator of G-protein signaling 1
SCPEP1 serine carboxypeptidase 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMC1A structural maintenance of chromosomes 1A
TFF3 trefoil factor 3 (intestinal)
TRIM2 tripartite motif containing 2
TXN thioredoxin
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae)
WNT5A wingless-type MMTV integration site family, member 5A
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
AKAP1 A kinase (PRKA) anchor protein 1
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
BCHE butyrylcholinesterase
C7 complement component 7
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDK6 cyclin-dependent kinase 6
CHRDL1 chordin-like 1
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CTSH cathepsin H
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
GRWD1 glutamate-rich WD repeat containing 1
GYG1 glycogenin 1
HIST1H2BG histone cluster 1, H2bg
HTRA1 HtrA serine peptidase 1
INPP5A inositol polyphosphate-5-phosphatase, 40kDa
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KANK2 KN motif and ankyrin repeat domains 2
KDM5D lysine (K)-specific demethylase 5D
PEG3 paternally expressed 3
PENK proenkephalin
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PTGDS prostaglandin D2 synthase 21kDa (brain)
S100A2 S100 calcium binding protein A2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SOX4 SRY (sex determining region Y)-box 4
TM4SF1 transmembrane 4 L six family member 1
TRIM28 tripartite motif containing 28
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