BRD-K50776152_cjd-pla-20-1_H1299_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

150 genes differentially expressed following the BRD-K50776152_cjd-pla-20-1_H1299_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADM adrenomedullin
ALOX5 arachidonate 5-lipoxygenase
AQP9 aquaporin 9
AREG amphiregulin
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ATF3 activating transcription factor 3
ATP11B ATPase, class VI, type 11B
BPHL biphenyl hydrolase-like (serine hydrolase)
CADM1 cell adhesion molecule 1
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CCNB1 cyclin B1
CD24 CD24 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CD93 CD93 molecule
COL11A1 collagen, type XI, alpha 1
COL15A1 collagen, type XV, alpha 1
COL4A1 collagen, type IV, alpha 1
COL4A5 collagen, type IV, alpha 5
COMP cartilage oligomeric matrix protein
CPA3 carboxypeptidase A3 (mast cell)
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DSP desmoplakin
F11R F11 receptor
FGFBP1 fibroblast growth factor binding protein 1
FGFR2 fibroblast growth factor receptor 2
GATA6 GATA binding protein 6
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
GPX2 glutathione peroxidase 2
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IER5 immediate early response 5
IFNAR1 interferon (alpha, beta and omega) receptor 1
IGFBP5 insulin-like growth factor binding protein 5
IL1B interleukin 1, beta
IRF6 interferon regulatory factor 6
JAG1 jagged 1
LMO3 LIM domain only 3 (rhombotin-like 2)
LST1 leukocyte specific transcript 1
MEF2C myocyte enhancer factor 2C
MFAP5 microfibrillar associated protein 5
MMP2 matrix metallopeptidase 2
MPZL2 myelin protein zero-like 2
MTSS1 metastasis suppressor 1
MXRA5 matrix-remodelling associated 5
NARFL nuclear prelamin A recognition factor-like
NIT1 nitrilase 1
ORC1 origin recognition complex, subunit 1
PAPD7 PAP associated domain containing 7
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PEG10 paternally expressed 10
RGCC regulator of cell cycle
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFRP4 secreted frizzled-related protein 4
SHB Src homology 2 domain containing adaptor protein B
SIRPA signal-regulatory protein alpha
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SNAI2 snail family zinc finger 2
SPARCL1 SPARC-like 1 (hevin)
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SULF1 sulfatase 1
SYNJ2 synaptojanin 2
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
THBS1 thrombospondin 1
TNS3 tensin 3
TRIB3 tribbles pseudokinase 3
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VEGFA vascular endothelial growth factor A
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
AMD1 adenosylmethionine decarboxylase 1
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BST2 bone marrow stromal cell antigen 2
CDC42 cell division cycle 42
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHPT1 choline phosphotransferase 1
CHRDL1 chordin-like 1
CLU clusterin
CTSB cathepsin B
DBF4 DBF4 zinc finger
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DLC1 DLC1 Rho GTPase activating protein
DUSP4 dual specificity phosphatase 4
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EXOSC9 exosome component 9
FAM216A family with sequence similarity 216, member A
GLRX glutaredoxin (thioltransferase)
GMDS GDP-mannose 4,6-dehydratase
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
HEBP1 heme binding protein 1
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
IFIT5 interferon-induced protein with tetratricopeptide repeats 5
IFITM2 interferon induced transmembrane protein 2
JADE2 jade family PHD finger 2
KANK2 KN motif and ankyrin repeat domains 2
KAZN kazrin, periplakin interacting protein
LTBP3 latent transforming growth factor beta binding protein 3
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MRPS30 mitochondrial ribosomal protein S30
NAP1L1 nucleosome assembly protein 1-like 1
NEFH neurofilament, heavy polypeptide
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NNMT nicotinamide N-methyltransferase
NPY neuropeptide Y
NPY1R neuropeptide Y receptor Y1
NUP98 nucleoporin 98kDa
OAT ornithine aminotransferase
OSBPL8 oxysterol binding protein-like 8
PARP2 poly (ADP-ribose) polymerase 2
PDLIM4 PDZ and LIM domain 4
PDZD8 PDZ domain containing 8
PENK proenkephalin
PLAC8 placenta-specific 8
PROM1 prominin 1
QDPR quinoid dihydropteridine reductase
RPN2 ribophorin II
RPS4Y1 ribosomal protein S4, Y-linked 1
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
S100A10 S100 calcium binding protein A10
SACS sacsin molecular chaperone
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SORD sorbitol dehydrogenase
STOM stomatin
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
TBC1D31 TBC1 domain family, member 31
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
UBE2S ubiquitin-conjugating enzyme E2S
UGCG UDP-glucose ceramide glucosyltransferase
ZNF131 zinc finger protein 131
Funding