BRD-K51189903_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

79 genes differentially expressed following the BRD-K51189903_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
CA2 carbonic anhydrase II
CCND2 cyclin D2
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CECR1 cat eye syndrome chromosome region, candidate 1
CLIP2 CAP-GLY domain containing linker protein 2
COL15A1 collagen, type XV, alpha 1
COL1A1 collagen, type I, alpha 1
DDIT4 DNA-damage-inducible transcript 4
DEPTOR DEP domain containing MTOR-interacting protein
EDNRB endothelin receptor type B
FGF13 fibroblast growth factor 13
FOLR1 folate receptor 1 (adult)
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GCH1 GTP cyclohydrolase 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HSPA1A heat shock 70kDa protein 1A
ITM2A integral membrane protein 2A
ITM2C integral membrane protein 2C
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
LGALS1 lectin, galactoside-binding, soluble, 1
LTF lactotransferrin
LUM lumican
MAP7 microtubule-associated protein 7
MAPT microtubule-associated protein tau
MARCH3 membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase
MATN2 matrilin 2
NEFH neurofilament, heavy polypeptide
NID2 nidogen 2 (osteonidogen)
OSR2 odd-skipped related transciption factor 2
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDZRN3 PDZ domain containing ring finger 3
PEG3 paternally expressed 3
PLXNC1 plexin C1
PRPH peripherin
QPCT glutaminyl-peptide cyclotransferase
RET ret proto-oncogene
RPP38 ribonuclease P/MRP 38kDa subunit
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A1 secretoglobin, family 2A, member 1
SFRP4 secreted frizzled-related protein 4
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TBX3 T-box 3
TSPYL5 TSPY-like 5
WARS tryptophanyl-tRNA synthetase

decreased expression

Symbol Name
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANKRD36B ankyrin repeat domain 36B
AQP3 aquaporin 3 (Gill blood group)
BCHE butyrylcholinesterase
BRD4 bromodomain containing 4
CD9 CD9 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNB2 ephrin-B2
EMP1 epithelial membrane protein 1
GAGE3 G antigen 3
GPRC5A G protein-coupled receptor, class C, group 5, member A
IL7R interleukin 7 receptor
LBH limb bud and heart development
LYPD1 LY6/PLAUR domain containing 1
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MET MET proto-oncogene, receptor tyrosine kinase
MTCL1 microtubule crosslinking factor 1
NMU neuromedin U
NRN1 neuritin 1
PLBD1 phospholipase B domain containing 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPL periplakin
RND3 Rho family GTPase 3
SDC4 syndecan 4
SLC35F2 solute carrier family 35, member F2
STK39 serine threonine kinase 39
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TUBB2A tubulin, beta 2A class IIa
WEE1 WEE1 G2 checkpoint kinase
Funding