BRD-K51189903_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

106 genes differentially expressed following the BRD-K51189903_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARG2 arginase 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
BANK1 B-cell scaffold protein with ankyrin repeats 1
CCDC109B coiled-coil domain containing 109B
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTH cystathionine gamma-lyase
DDIT4 DNA-damage-inducible transcript 4
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EVI2A ecotropic viral integration site 2A
FHL1 four and a half LIM domains 1
G0S2 G0/G1 switch 2
GREM1 gremlin 1, DAN family BMP antagonist
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ITM2C integral membrane protein 2C
LCN2 lipocalin 2
LPAR6 lysophosphatidic acid receptor 6
LTB lymphotoxin beta (TNF superfamily, member 3)
LXN latexin
LY96 lymphocyte antigen 96
MAP7 microtubule-associated protein 7
MKNK1 MAP kinase interacting serine/threonine kinase 1
NNMT nicotinamide N-methyltransferase
NPTX2 neuronal pentraxin II
PDLIM3 PDZ and LIM domain 3
PDLIM4 PDZ and LIM domain 4
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLK2 polo-like kinase 2
PON2 paraoxonase 2
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTPRD protein tyrosine phosphatase, receptor type, D
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
PXDN peroxidasin
RPS4Y1 ribosomal protein S4, Y-linked 1
RTN2 reticulon 2
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SGK1 serum/glucocorticoid regulated kinase 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC38A6 solute carrier family 38, member 6
SOCS2 suppressor of cytokine signaling 2
SPP1 secreted phosphoprotein 1
SRGN serglycin
SST somatostatin
STEAP1 six transmembrane epithelial antigen of the prostate 1
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
TARP TCR gamma alternate reading frame protein
TGFBI transforming growth factor, beta-induced, 68kDa
TM6SF1 transmembrane 6 superfamily member 1
TMEM100 transmembrane protein 100
TNNT1 troponin T type 1 (skeletal, slow)
TPD52L1 tumor protein D52-like 1
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
WSB1 WD repeat and SOCS box containing 1
XYLT1 xylosyltransferase I
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BST2 bone marrow stromal cell antigen 2
CA12 carbonic anhydrase XII
CDA cytidine deaminase
CES1 carboxylesterase 1
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
ERBB4 erb-b2 receptor tyrosine kinase 4
FAM46A family with sequence similarity 46, member A
FOLR1 folate receptor 1 (adult)
FOSL1 FOS-like antigen 1
FST follistatin
FZD7 frizzled class receptor 7
GPRC5A G protein-coupled receptor, class C, group 5, member A
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IQGAP1 IQ motif containing GTPase activating protein 1
KYNU kynureninase
LAMP3 lysosomal-associated membrane protein 3
LPL lipoprotein lipase
MARCKS myristoylated alanine-rich protein kinase C substrate
MEGF9 multiple EGF-like-domains 9
NAV2 neuron navigator 2
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
PFN2 profilin 2
PLK1 polo-like kinase 1
PRKCD protein kinase C, delta
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SPEN spen family transcriptional repressor
SPRED2 sprouty-related, EVH1 domain containing 2
TNS3 tensin 3
TREM1 triggering receptor expressed on myeloid cells 1
TRIO trio Rho guanine nucleotide exchange factor
TUBB2A tubulin, beta 2A class IIa
Funding