BRD-K51313569_palbociclib_A375_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

96 genes differentially expressed following the BRD-K51313569_palbociclib_A375_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIRF adipogenesis regulatory factor
AHNAK2 AHNAK nucleoprotein 2
AMIGO2 adhesion molecule with Ig-like domain 2
APOD apolipoprotein D
ASS1 argininosuccinate synthase 1
BMP4 bone morphogenetic protein 4
BST2 bone marrow stromal cell antigen 2
C9ORF16 chromosome 9 open reading frame 16
CES2 carboxylesterase 2
CFB complement factor B
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL14 chemokine (C-X-C motif) ligand 14
CYFIP2 cytoplasmic FMR1 interacting protein 2
DKK3 dickkopf WNT signaling pathway inhibitor 3
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FOLR1 folate receptor 1 (adult)
FPGS folylpolyglutamate synthase
GREM1 gremlin 1, DAN family BMP antagonist
GSN gelsolin
HMGA1 high mobility group AT-hook 1
IFI27 interferon, alpha-inducible protein 27
ISG15 ISG15 ubiquitin-like modifier
KRT8 keratin 8, type II
LAMP2 lysosomal-associated membrane protein 2
LDOC1 leucine zipper, down-regulated in cancer 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LGALS4 lectin, galactoside-binding, soluble, 4
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LOXL2 lysyl oxidase-like 2
LYZ lysozyme
MDK midkine (neurite growth-promoting factor 2)
MGP matrix Gla protein
MMP1 matrix metallopeptidase 1
MT1X metallothionein 1X
MVP major vault protein
MXRA5 matrix-remodelling associated 5
NDRG1 N-myc downstream regulated 1
NELL2 NEL-like 2 (chicken)
NPDC1 neural proliferation, differentiation and control, 1
NRCAM neuronal cell adhesion molecule
PDGFC platelet derived growth factor C
PEX11A peroxisomal biogenesis factor 11 alpha
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSD3 pleckstrin and Sec7 domain containing 3
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTPRC protein tyrosine phosphatase, receptor type, C
PYCARD PYD and CARD domain containing
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SST somatostatin
SYBU syntabulin (syntaxin-interacting)
TGFB1 transforming growth factor, beta 1
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TPD52L1 tumor protein D52-like 1
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AMD1 adenosylmethionine decarboxylase 1
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNA2 cyclin A2
CCND2 cyclin D2
CCNE2 cyclin E2
CD59 CD59 molecule, complement regulatory protein
CDC42 cell division cycle 42
CDC6 cell division cycle 6
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CENPU centromere protein U
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM129A family with sequence similarity 129, member A
FEN1 flap structure-specific endonuclease 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GSTP1 glutathione S-transferase pi 1
IPO5 importin 5
KIF11 kinesin family member 11
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM4 minichromosome maintenance complex component 4
MICB MHC class I polypeptide-related sequence B
NCAPG non-SMC condensin I complex, subunit G
NUSAP1 nucleolar and spindle associated protein 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRKD3 protein kinase D3
PSPH phosphoserine phosphatase
RRM2 ribonucleotide reductase M2
SEPP1 selenoprotein P, plasma, 1
SQRDL sulfide quinone reductase-like (yeast)
STMN1 stathmin 1
TACSTD2 tumor-associated calcium signal transducer 2
ZNF22 zinc finger protein 22
Funding