BRD-K51313569_palbociclib_HS578T_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

161 genes differentially expressed following the BRD-K51313569_palbociclib_HS578T_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
AKR1C1 aldo-keto reductase family 1, member C1
ASS1 argininosuccinate synthase 1
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BHLHE41 basic helix-loop-helix family, member e41
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C3 complement component 3
CD47 CD47 molecule
CD8A CD8a molecule
CFI complement factor I
COL18A1 collagen, type XVIII, alpha 1
COL4A5 collagen, type IV, alpha 5
CST1 cystatin SN
EGR1 early growth response 1
HIST1H2AC histone cluster 1, H2ac
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HP haptoglobin
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP6 insulin-like growth factor binding protein 6
IL32 interleukin 32
KIF5C kinesin family member 5C
KRT14 keratin 14, type I
LAMC2 laminin, gamma 2
LEPROT leptin receptor overlapping transcript
LOC100505650 uncharacterized LOC100505650
LYRM1 LYR motif containing 1
MME membrane metallo-endopeptidase
NMRK1 nicotinamide riboside kinase 1
OXTR oxytocin receptor
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PRKCI protein kinase C, iota
PRKCQ protein kinase C, theta
PSPH phosphoserine phosphatase
RBP1 retinol binding protein 1, cellular
RBP4 retinol binding protein 4, plasma
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RPL31 ribosomal protein L31
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SIRT3 sirtuin 3
SLC38A1 solute carrier family 38, member 1
SOX17 SRY (sex determining region Y)-box 17
STC2 stanniocalcin 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
CCNA2 cyclin A2
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CENPU centromere protein U
CXCL14 chemokine (C-X-C motif) ligand 14
DCK deoxycytidine kinase
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DONSON downstream neighbor of SON
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FANCI Fanconi anemia, complementation group I
FBXO5 F-box protein 5
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
H2AFX H2A histone family, member X
HES1 hes family bHLH transcription factor 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HJURP Holliday junction recognition protein
HMGB2 high mobility group box 2
IRS2 insulin receptor substrate 2
KDM5D lysine (K)-specific demethylase 5D
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF4A kinesin family member 4A
KLF4 Kruppel-like factor 4 (gut)
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MDFIC MyoD family inhibitor domain containing
MELK maternal embryonic leucine zipper kinase
MGLL monoglyceride lipase
MKI67 marker of proliferation Ki-67
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPG non-SMC condensin I complex, subunit G
NCAPH non-SMC condensin I complex, subunit H
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NID1 nidogen 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NTS neurotensin
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
PBK PDZ binding kinase
PLK1 polo-like kinase 1
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RACGAP1 Rac GTPase activating protein 1
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RCC1 regulator of chromosome condensation 1
RFC5 replication factor C (activator 1) 5, 36.5kDa
RPS4Y1 ribosomal protein S4, Y-linked 1
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
S100P S100 calcium binding protein P
SHCBP1 SHC SH2-domain binding protein 1
SMC4 structural maintenance of chromosomes 4
STMN1 stathmin 1
TACC3 transforming, acidic coiled-coil containing protein 3
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TIMELESS timeless circadian clock
TMEM194A transmembrane protein 194A
TMPO thymopoietin
TMSB15A thymosin beta 15a
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein
Funding