BRD-K51313569_palbociclib_LNCAP_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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64 genes differentially expressed following the BRD-K51313569_palbociclib_LNCAP_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARMCX3 armadillo repeat containing, X-linked 3
BLNK B-cell linker
CCL4 chemokine (C-C motif) ligand 4
CDC20 cell division cycle 20
CDKN2A cyclin-dependent kinase inhibitor 2A
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CX3CL1 chemokine (C-X3-C motif) ligand 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL12 chemokine (C-X-C motif) ligand 12
EDNRB endothelin receptor type B
FAXDC2 fatty acid hydroxylase domain containing 2
FHL1 four and a half LIM domains 1
GPM6B glycoprotein M6B
HBD hemoglobin, delta
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
JCHAIN joining chain of multimeric IgA and IgM
KRT8 keratin 8, type II
MFAP4 microfibrillar-associated protein 4
MPPED2 metallophosphoesterase domain containing 2
NPIPB3 nuclear pore complex interacting protein family, member B3
PCNA proliferating cell nuclear antigen
PDE8B phosphodiesterase 8B
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGS1 regulator of G-protein signaling 1
S100A8 S100 calcium binding protein A8
SDPR serum deprivation response
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SIRT3 sirtuin 3
TBX2 T-box 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
VAMP8 vesicle-associated membrane protein 8

decreased expression

Symbol Name
ADCY1 adenylate cyclase 1 (brain)
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
APOD apolipoprotein D
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CPB1 carboxypeptidase B1 (tissue)
CXADR coxsackie virus and adenovirus receptor
CXCL14 chemokine (C-X-C motif) ligand 14
DEGS1 delta(4)-desaturase, sphingolipid 1
FABP4 fatty acid binding protein 4, adipocyte
FN1 fibronectin 1
GMNN geminin, DNA replication inhibitor
GPNMB glycoprotein (transmembrane) nmb
GRB7 growth factor receptor-bound protein 7
HSPA8 heat shock 70kDa protein 8
IFI6 interferon, alpha-inducible protein 6
KLK10 kallikrein-related peptidase 10
KLK6 kallikrein-related peptidase 6
MAB21L1 mab-21-like 1 (C. elegans)
MAP7 microtubule-associated protein 7
MAPK6 mitogen-activated protein kinase 6
MFSD10 major facilitator superfamily domain containing 10
NNMT nicotinamide N-methyltransferase
OXA1L oxidase (cytochrome c) assembly 1-like
SNAP25 synaptosomal-associated protein, 25kDa
SPP1 secreted phosphoprotein 1
STMN2 stathmin 2
TM4SF1 transmembrane 4 L six family member 1
TOX3 TOX high mobility group box family member 3
WDR76 WD repeat domain 76