BRD-K51313569_palbociclib_MCF10A_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

173 genes differentially expressed following the BRD-K51313569_palbociclib_MCF10A_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRG2 adhesion G protein-coupled receptor G2
AMDHD2 amidohydrolase domain containing 2
BASP1 brain abundant, membrane attached signal protein 1
C3 complement component 3
CFB complement factor B
CLU clusterin
CRIP1 cysteine-rich protein 1 (intestinal)
DSP desmoplakin
ELOVL4 ELOVL fatty acid elongase 4
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ESR1 estrogen receptor 1
FADS1 fatty acid desaturase 1
FAM63A family with sequence similarity 63, member A
FLG filaggrin
FOLR1 folate receptor 1 (adult)
HACD1 3-hydroxyacyl-CoA dehydratase 1
HBB hemoglobin, beta
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IGFBP3 insulin-like growth factor binding protein 3
IL1B interleukin 1, beta
KRT19 keratin 19, type I
KRT6A keratin 6A, type II
KRT7 keratin 7, type II
LDOC1 leucine zipper, down-regulated in cancer 1
LTBP1 latent transforming growth factor beta binding protein 1
LXN latexin
MAP7 microtubule-associated protein 7
MLPH melanophilin
MTSS1 metastasis suppressor 1
MVP major vault protein
MXRA5 matrix-remodelling associated 5
NEBL nebulette
NMNAT2 nicotinamide nucleotide adenylyltransferase 2
ORAI3 ORAI calcium release-activated calcium modulator 3
PCP4 Purkinje cell protein 4
PRDX1 peroxiredoxin 1
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PYCARD PYD and CARD domain containing
QPRT quinolinate phosphoribosyltransferase
RABAC1 Rab acceptor 1 (prenylated)
RNASET2 ribonuclease T2
S100A7 S100 calcium binding protein A7
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SFN stratifin
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLPI secretory leukocyte peptidase inhibitor
TACSTD2 tumor-associated calcium signal transducer 2
TFPI2 tissue factor pathway inhibitor 2
TM4SF1 transmembrane 4 L six family member 1
WFDC2 WAP four-disulfide core domain 2

decreased expression

Symbol Name
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ANXA1 annexin A1
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
BTG3 BTG family, member 3
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
CCNA2 cyclin A2
CCNB1 cyclin B1
CCNB2 cyclin B2
CCND2 cyclin D2
CCNF cyclin F
CDC20 cell division cycle 20
CDC45 cell division cycle 45
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CIT citron rho-interacting serine/threonine kinase
COL3A1 collagen, type III, alpha 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DBF4 DBF4 zinc finger
DCN decorin
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
E2F2 E2F transcription factor 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF5 eukaryotic translation initiation factor 5
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
EXO1 exonuclease 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM64A family with sequence similarity 64, member A
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FGFR3 fibroblast growth factor receptor 3
FOXM1 forkhead box M1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GMNN geminin, DNA replication inhibitor
GTSE1 G-2 and S-phase expressed 1
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
H2AFV H2A histone family, member V
HIST1H2BG histone cluster 1, H2bg
HIST1H4C histone cluster 1, H4c
HJURP Holliday junction recognition protein
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF4A kinesin family member 4A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LBR lamin B receptor
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LUM lumican
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MCM10 minichromosome maintenance complex component 10
MCM7 minichromosome maintenance complex component 7
MGP matrix Gla protein
MKI67 marker of proliferation Ki-67
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPD2 non-SMC condensin I complex, subunit D2
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NCAPH non-SMC condensin I complex, subunit H
NDC80 NDC80 kinetochore complex component
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NEK2 NIMA-related kinase 2
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
OLFM4 olfactomedin 4
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PHGDH phosphoglycerate dehydrogenase
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POSTN periostin, osteoblast specific factor
PRC1 protein regulator of cytokinesis 1
PSRC1 proline/serine-rich coiled-coil 1
PTTG1 pituitary tumor-transforming 1
RACGAP1 Rac GTPase activating protein 1
RAD51AP1 RAD51 associated protein 1
RFC3 replication factor C (activator 1) 3, 38kDa
RHOBTB3 Rho-related BTB domain containing 3
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SAP30 Sin3A-associated protein, 30kDa
SHCBP1 SHC SH2-domain binding protein 1
SMC1A structural maintenance of chromosomes 1A
SMC4 structural maintenance of chromosomes 4
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPAG5 sperm associated antigen 5
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPC25 SPC25, NDC80 kinetochore complex component
STMN1 stathmin 1
TK1 thymidine kinase 1, soluble
TMEM194A transmembrane protein 194A
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
Funding