BRD-K51377689_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

85 genes differentially expressed following the BRD-K51377689_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADORA2B adenosine A2b receptor
AHNAK AHNAK nucleoprotein
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ARG2 arginase 2
BASP1 brain abundant, membrane attached signal protein 1
BTG2 BTG family, member 2
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CSRP2 cysteine and glycine-rich protein 2
CXCL8 chemokine (C-X-C motif) ligand 8
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
FOSL1 FOS-like antigen 1
FSD1 fibronectin type III and SPRY domain containing 1
FTH1 ferritin, heavy polypeptide 1
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
KRT17 keratin 17, type I
KRT19 keratin 19, type I
LY75 lymphocyte antigen 75
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MMP7 matrix metallopeptidase 7
MTCL1 microtubule crosslinking factor 1
PLAC8 placenta-specific 8
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RAP1GAP RAP1 GTPase activating protein
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGS2 regulator of G-protein signaling 2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SERTAD2 SERTA domain containing 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLPI secretory leukocyte peptidase inhibitor
SRGN serglycin
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM45A transmembrane protein 45A
TRIM16 tripartite motif containing 16
TSKU tsukushi, small leucine rich proteoglycan
TXNRD1 thioredoxin reductase 1

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AGR2 anterior gradient 2
ALDOB aldolase B, fructose-bisphosphate
CA2 carbonic anhydrase II
CCNF cyclin F
CPA3 carboxypeptidase A3 (mast cell)
CPE carboxypeptidase E
EDNRB endothelin receptor type B
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EVL Enah/Vasp-like
FGF13 fibroblast growth factor 13
FHL1 four and a half LIM domains 1
GREM1 gremlin 1, DAN family BMP antagonist
GSN gelsolin
GSTZ1 glutathione S-transferase zeta 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
ISG15 ISG15 ubiquitin-like modifier
LAGE3 L antigen family, member 3
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MARCKSL1 MARCKS-like 1
MFAP5 microfibrillar associated protein 5
MT1E metallothionein 1E
MYBPC1 myosin binding protein C, slow type
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NFIB nuclear factor I/B
OSR2 odd-skipped related transciption factor 2
PDLIM3 PDZ and LIM domain 3
PLK2 polo-like kinase 2
PTGIS prostaglandin I2 (prostacyclin) synthase
PXDN peroxidasin
RGS5 regulator of G-protein signaling 5
RPL37A ribosomal protein L37a
SPINK1 serine peptidase inhibitor, Kazal type 1
SPON1 spondin 1, extracellular matrix protein
TFF1 trefoil factor 1
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TPBG trophoblast glycoprotein
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