BRD-K51556300_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

93 genes differentially expressed following the BRD-K51556300_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2
ADIRF adipogenesis regulatory factor
AQP1 aquaporin 1 (Colton blood group)
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CD38 CD38 molecule
CEMIP cell migration inducing protein, hyaluronan binding
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLC Charcot-Leyden crystal galectin
CLDN3 claudin 3
CRABP2 cellular retinoic acid binding protein 2
CTBP2 C-terminal binding protein 2
DCN decorin
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EML3 echinoderm microtubule associated protein like 3
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
GLRX glutaredoxin (thioltransferase)
GOLGA4 golgin A4
GREM1 gremlin 1, DAN family BMP antagonist
GSDMB gasdermin B
H1F0 H1 histone family, member 0
HBB hemoglobin, beta
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HYOU1 hypoxia up-regulated 1
IGKC immunoglobulin kappa constant
IGKV4-1 immunoglobulin kappa variable 4-1
ITM2C integral membrane protein 2C
JCHAIN joining chain of multimeric IgA and IgM
KRT18 keratin 18, type I
LGALS1 lectin, galactoside-binding, soluble, 1
LIMCH1 LIM and calponin homology domains 1
LXN latexin
MAP7 microtubule-associated protein 7
MCAM melanoma cell adhesion molecule
MEST mesoderm specific transcript
MMP9 matrix metallopeptidase 9
MT1M metallothionein 1M
NEBL nebulette
NNMT nicotinamide N-methyltransferase
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDE4B phosphodiesterase 4B, cAMP-specific
PON3 paraoxonase 3
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRUNE2 prune homolog 2 (Drosophila)
QPCT glutaminyl-peptide cyclotransferase
RAI14 retinoic acid induced 14
RGCC regulator of cell cycle
RHOB ras homolog family member B
SCGB1D2 secretoglobin, family 1D, member 2
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SOCS2 suppressor of cytokine signaling 2
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TPD52 tumor protein D52
TPD52L1 tumor protein D52-like 1
TUBB2A tubulin, beta 2A class IIa
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
XBP1 X-box binding protein 1
ZDHHC11 zinc finger, DHHC-type containing 11

decreased expression

Symbol Name
ADGRL2 adhesion G protein-coupled receptor L2
AIM2 absent in melanoma 2
CCND1 cyclin D1
CPVL carboxypeptidase, vitellogenic-like
DHRS2 dehydrogenase/reductase (SDR family) member 2
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
F13A1 coagulation factor XIII, A1 polypeptide
FXYD3 FXYD domain containing ion transport regulator 3
GOLGA8A golgin A8 family, member A
IFI16 interferon, gamma-inducible protein 16
IL1R2 interleukin 1 receptor, type II
KRT17 keratin 17, type I
MXRA5 matrix-remodelling associated 5
NAV3 neuron navigator 3
NREP neuronal regeneration related protein
PLTP phospholipid transfer protein
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
RXRA retinoid X receptor, alpha
SCML1 sex comb on midleg-like 1 (Drosophila)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFRP1 secreted frizzled-related protein 1
SPEN spen family transcriptional repressor
TMEM97 transmembrane protein 97
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSPAN8 tetraspanin 8