BRD-K51575138_TPCA-1_HA1E_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

94 genes differentially expressed following the BRD-K51575138_TPCA-1_HA1E_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C3 aldo-keto reductase family 1, member C3
ANXA3 annexin A3
AQP3 aquaporin 3 (Gill blood group)
ASNS asparagine synthetase (glutamine-hydrolyzing)
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CCNG2 cyclin G2
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXD1 forkhead box D1
GCLC glutamate-cysteine ligase, catalytic subunit
GSTP1 glutathione S-transferase pi 1
IFRD2 interferon-related developmental regulator 2
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
IRS2 insulin receptor substrate 2
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KDM5D lysine (K)-specific demethylase 5D
MSMB microseminoprotein, beta-
MSRB2 methionine sulfoxide reductase B2
MYOF myoferlin
PHGDH phosphoglycerate dehydrogenase
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
PRKCB protein kinase C, beta
RPS4Y1 ribosomal protein S4, Y-linked 1
RTN1 reticulon 1
S100P S100 calcium binding protein P
SIK1 salt-inducible kinase 1
TARBP1 TAR (HIV-1) RNA binding protein 1
TARP TCR gamma alternate reading frame protein
TPD52L1 tumor protein D52-like 1

decreased expression

Symbol Name
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
AQP1 aquaporin 1 (Colton blood group)
BHLHE41 basic helix-loop-helix family, member e41
CADM1 cell adhesion molecule 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCL2 chemokine (C-C motif) ligand 2
CCNB1 cyclin B1
CD93 CD93 molecule
COL1A1 collagen, type I, alpha 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYBA cytochrome b-245, alpha polypeptide
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
ELOVL2 ELOVL fatty acid elongase 2
EMP1 epithelial membrane protein 1
F13A1 coagulation factor XIII, A1 polypeptide
GAS7 growth arrest-specific 7
GNG11 guanine nucleotide binding protein (G protein), gamma 11
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
IER3 immediate early response 3
IFI16 interferon, gamma-inducible protein 16
IFI27 interferon, alpha-inducible protein 27
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IL6 interleukin 6
IRF7 interferon regulatory factor 7
ISG15 ISG15 ubiquitin-like modifier
KCTD12 potassium channel tetramerization domain containing 12
KRT19 keratin 19, type I
LMO2 LIM domain only 2 (rhombotin-like 1)
LOC100505650 uncharacterized LOC100505650
MAL mal, T-cell differentiation protein
MAP1B microtubule-associated protein 1B
MARCKSL1 MARCKS-like 1
MDK midkine (neurite growth-promoting factor 2)
MSX1 msh homeobox 1
MX1 MX dynamin-like GTPase 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PLA1A phospholipase A1 member A
PLAT plasminogen activator, tissue
PLIN2 perilipin 2
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PRAME preferentially expressed antigen in melanoma
PROM1 prominin 1
PTX3 pentraxin 3, long
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SCGB2A2 secretoglobin, family 2A, member 2
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SMAD3 SMAD family member 3
SPAG4 sperm associated antigen 4
SRPX sushi-repeat containing protein, X-linked
TCTN1 tectonic family member 1
THBD thrombomodulin
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNS1 tensin 1
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
XIST X inactive specific transcript (non-protein coding)
Funding