BRD-K51575138_TPCA-1_SNGM_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

145 genes differentially expressed following the BRD-K51575138_TPCA-1_SNGM_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALDOB aldolase B, fructose-bisphosphate
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
AQP1 aquaporin 1 (Colton blood group)
ARL4C ADP-ribosylation factor-like 4C
ASNS asparagine synthetase (glutamine-hydrolyzing)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLEC2B C-type lectin domain family 2, member B
COG2 component of oligomeric golgi complex 2
CRABP2 cellular retinoic acid binding protein 2
CREB1 cAMP responsive element binding protein 1
CST1 cystatin SN
CXADR coxsackie virus and adenovirus receptor
CXCR4 chemokine (C-X-C motif) receptor 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EFNB2 ephrin-B2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EMX2 empty spiracles homeobox 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GPR183 G protein-coupled receptor 183
HIST1H1C histone cluster 1, H1c
HOXA10 homeobox A10
HOXA5 homeobox A5
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
KDM5D lysine (K)-specific demethylase 5D
KLK5 kallikrein-related peptidase 5
MARS methionyl-tRNA synthetase
MMP12 matrix metallopeptidase 12
NR1D2 nuclear receptor subfamily 1, group D, member 2
PDZD8 PDZ domain containing 8
PIH1D1 PIH1 domain containing 1
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
PSPH phosphoserine phosphatase
REG3A regenerating islet-derived 3 alpha
RPS4Y1 ribosomal protein S4, Y-linked 1
SCAF8 SR-related CTD-associated factor 8
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SPON2 spondin 2, extracellular matrix protein
TACSTD2 tumor-associated calcium signal transducer 2
TARP TCR gamma alternate reading frame protein
TARS threonyl-tRNA synthetase
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TIMP3 TIMP metallopeptidase inhibitor 3
TSC22D3 TSC22 domain family, member 3
TTC39A tetratricopeptide repeat domain 39A
XBP1 X-box binding protein 1
ZHX2 zinc fingers and homeoboxes 2
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
ABHD3 abhydrolase domain containing 3
AES amino-terminal enhancer of split
AMIGO2 adhesion molecule with Ig-like domain 2
ANKRD36B ankyrin repeat domain 36B
ANXA4 annexin A4
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
BRCA1 breast cancer 1, early onset
C2CD5 C2 calcium-dependent domain containing 5
CADPS2 Ca++-dependent secretion activator 2
CAV1 caveolin 1, caveolae protein, 22kDa
CCND2 cyclin D2
CHPT1 choline phosphotransferase 1
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COCH cochlin
CSRP1 cysteine and glycine-rich protein 1
CTSS cathepsin S
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DPYSL3 dihydropyrimidinase-like 3
DRAM1 DNA-damage regulated autophagy modulator 1
EIF5 eukaryotic translation initiation factor 5
FKBP1A FK506 binding protein 1A, 12kDa
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
HBB hemoglobin, beta
HMGA2 high mobility group AT-hook 2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IFI16 interferon, gamma-inducible protein 16
IGHM immunoglobulin heavy constant mu
IGLV2-23 immunoglobulin lambda variable 2-23
IL32 interleukin 32
JCHAIN joining chain of multimeric IgA and IgM
KIAA1033 KIAA1033
KLF5 Kruppel-like factor 5 (intestinal)
KRT7 keratin 7, type II
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LINC00342 long intergenic non-protein coding RNA 342
LOC100272216 uncharacterized LOC100272216
LONP2 lon peptidase 2, peroxisomal
LTBP2 latent transforming growth factor beta binding protein 2
MAGED1 melanoma antigen family D1
MAN1A1 mannosidase, alpha, class 1A, member 1
MCM6 minichromosome maintenance complex component 6
MEG3 maternally expressed 3 (non-protein coding)
MET MET proto-oncogene, receptor tyrosine kinase
METTL3 methyltransferase like 3
MLXIP MLX interacting protein
MSLN mesothelin
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYO5C myosin VC
MZB1 marginal zone B and B1 cell-specific protein
NBPF10 neuroblastoma breakpoint family, member 10
NTS neurotensin
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OXA1L oxidase (cytochrome c) assembly 1-like
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PIP prolactin-induced protein
PKM pyruvate kinase, muscle
PLAT plasminogen activator, tissue
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PTPRK protein tyrosine phosphatase, receptor type, K
RIN2 Ras and Rab interactor 2
RSRP1 arginine/serine-rich protein 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SFRP1 secreted frizzled-related protein 1
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SMC4 structural maintenance of chromosomes 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TES testin LIM domain protein
TFRC transferrin receptor
TM4SF1 transmembrane 4 L six family member 1
TMEM243 transmembrane protein 243, mitochondrial
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRIM22 tripartite motif containing 22
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TUBB4B tubulin, beta 4B class IVb
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
WFDC2 WAP four-disulfide core domain 2
XIST X inactive specific transcript (non-protein coding)
Funding