BRD-K51608872_N,N-dimethyl-6-({[1-(1-naphthyl)-1H-tetrazol-5-yl]thio}methyl)-1,3,5-triazine-2,4-diamine_A549_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

172 genes differentially expressed following the BRD-K51608872_N,N-dimethyl-6-({[1-(1-naphthyl)-1H-tetrazol-5-yl]thio}methyl)-1,3,5-triazine-2,4-diamine_A549_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ADGRG2 adhesion G protein-coupled receptor G2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AOX1 aldehyde oxidase 1
AP2B1 adaptor-related protein complex 2, beta 1 subunit
APOD apolipoprotein D
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAX BCL2-associated X protein
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCL2 chemokine (C-C motif) ligand 2
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHIC2 cysteine-rich hydrophobic domain 2
CTGF connective tissue growth factor
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
CYTL1 cytokine-like 1
DCN decorin
DDB2 damage-specific DNA binding protein 2, 48kDa
DKK3 dickkopf WNT signaling pathway inhibitor 3
DUSP6 dual specificity phosphatase 6
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNA1 ephrin-A1
ELF1 E74-like factor 1 (ets domain transcription factor)
EMP1 epithelial membrane protein 1
FBLN1 fibulin 1
FDXR ferredoxin reductase
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FILIP1L filamin A interacting protein 1-like
FOSL1 FOS-like antigen 1
GADD45B growth arrest and DNA-damage-inducible, beta
GNG11 guanine nucleotide binding protein (G protein), gamma 11
HBB hemoglobin, beta
HOPX HOP homeobox
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IL32 interleukin 32
IRS2 insulin receptor substrate 2
KYNU kynureninase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAOA monoamine oxidase A
MBNL2 muscleblind-like splicing regulator 2
MGP matrix Gla protein
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NEFH neurofilament, heavy polypeptide
NFE2L3 nuclear factor, erythroid 2-like 3
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NINJ1 ninjurin 1
NMT2 N-myristoyltransferase 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
PAMR1 peptidase domain containing associated with muscle regeneration 1
PCDH9 protocadherin 9
PDGFC platelet derived growth factor C
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PLAU plasminogen activator, urokinase
PMP22 peripheral myelin protein 22
PPAP2B phosphatidic acid phosphatase type 2B
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RFTN1 raftlin, lipid raft linker 1
RGCC regulator of cell cycle
RPS27L ribosomal protein S27-like
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SAP18 Sin3A-associated protein, 18kDa
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SESN1 sestrin 1
SFRP4 secreted frizzled-related protein 4
SORBS2 sorbin and SH3 domain containing 2
SOX9 SRY (sex determining region Y)-box 9
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SRPX sushi-repeat containing protein, X-linked
STOM stomatin
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TP53 tumor protein p53
TRIM22 tripartite motif containing 22
TXNIP thioredoxin interacting protein
ZBTB16 zinc finger and BTB domain containing 16
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ASNS asparagine synthetase (glutamine-hydrolyzing)
AUTS2 autism susceptibility candidate 2
BAG2 BCL2-associated athanogene 2
BAMBI BMP and activin membrane-bound inhibitor
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CA12 carbonic anhydrase XII
CBR1 carbonyl reductase 1
CD24 CD24 molecule
CLNS1A chloride channel, nucleotide-sensitive, 1A
CTR9 CTR9, Paf1/RNA polymerase II complex component
CTSL cathepsin L
CYCS cytochrome c, somatic
DSC2 desmocollin 2
EMP2 epithelial membrane protein 2
ENO2 enolase 2 (gamma, neuronal)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FASTKD5 FAST kinase domains 5
FGFR3 fibroblast growth factor receptor 3
FXYD3 FXYD domain containing ion transport regulator 3
GLO1 glyoxalase I
GPNMB glycoprotein (transmembrane) nmb
GPX3 glutathione peroxidase 3
GRSF1 G-rich RNA sequence binding factor 1
GYS1 glycogen synthase 1 (muscle)
HAPLN1 hyaluronan and proteoglycan link protein 1
HEXIM1 hexamethylene bis-acetamide inducible 1
HMOX1 heme oxygenase 1
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HPRT1 hypoxanthine phosphoribosyltransferase 1
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LCN2 lipocalin 2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
NOLC1 nucleolar and coiled-body phosphoprotein 1
NR2F6 nuclear receptor subfamily 2, group F, member 6
OAT ornithine aminotransferase
PAGR1 PAXIP1 associated glutamate-rich protein 1
PFN2 profilin 2
PGK1 phosphoglycerate kinase 1
PITX1 paired-like homeodomain 1
PLBD1 phospholipase B domain containing 1
PLIN2 perilipin 2
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1
RPL10 ribosomal protein L10
RPP25 ribonuclease P/MRP 25kDa subunit
RUFY3 RUN and FYVE domain containing 3
S100A14 S100 calcium binding protein A14
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFN stratifin
SHQ1 SHQ1, H/ACA ribonucleoprotein assembly factor
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPRR1A small proline-rich protein 1A
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TACSTD2 tumor-associated calcium signal transducer 2
TARBP1 TAR (HIV-1) RNA binding protein 1
TMEM2 transmembrane protein 2
TNNT1 troponin T type 1 (skeletal, slow)
TNS1 tensin 1
TPM4 tropomyosin 4
TUBB6 tubulin, beta 6 class V
TUSC3 tumor suppressor candidate 3
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGCG UDP-glucose ceramide glucosyltransferase
URI1 URI1, prefoldin-like chaperone
VLDLR very low density lipoprotein receptor
XBP1 X-box binding protein 1
Funding