BRD-K52075040_-666_A375_6.0_h_44.4_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

69 genes differentially expressed following the BRD-K52075040_-666_A375_6.0_h_44.4_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CHMP1B charged multivesicular body protein 1B
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DSG3 desmoglein 3
DUSP1 dual specificity phosphatase 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
ISLR immunoglobulin superfamily containing leucine-rich repeat
JUN jun proto-oncogene
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
NUPR1 nuclear protein, transcriptional regulator, 1
OSER1 oxidative stress responsive serine-rich 1
PIR pirin (iron-binding nuclear protein)
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RNMT RNA (guanine-7-) methyltransferase
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
TXNIP thioredoxin interacting protein
TXNL4B thioredoxin-like 4B
TXNRD1 thioredoxin reductase 1
XBP1 X-box binding protein 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ALCAM activated leukocyte cell adhesion molecule
AREG amphiregulin
BAMBI BMP and activin membrane-bound inhibitor
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CCND1 cyclin D1
CD24 CD24 molecule
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
DUSP4 dual specificity phosphatase 4
ERBB3 erb-b2 receptor tyrosine kinase 3
EREG epiregulin
FZD7 frizzled class receptor 7
HES1 hes family bHLH transcription factor 1
KANK1 KN motif and ankyrin repeat domains 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MCAM melanoma cell adhesion molecule
NFIB nuclear factor I/B
PLA2G16 phospholipase A2, group XVI
PPAP2C phosphatidic acid phosphatase type 2C
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SMAD3 SMAD family member 3
SOX9 SRY (sex determining region Y)-box 9
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TMEM2 transmembrane protein 2
TMEM47 transmembrane protein 47
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
UPK1B uroplakin 1B