BRD-K52850071_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

76 genes differentially expressed following the BRD-K52850071_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ACKR3 atypical chemokine receptor 3
AQP3 aquaporin 3 (Gill blood group)
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
BCL6 B-cell CLL/lymphoma 6
C6ORF48 chromosome 6 open reading frame 48
CBS cystathionine-beta-synthase
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COBL cordon-bleu WH2 repeat protein
DDIT4 DNA-damage-inducible transcript 4
DFNA5 deafness, autosomal dominant 5
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EGR1 early growth response 1
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
GARS glycyl-tRNA synthetase
INHBA inhibin, beta A
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1M metallothionein 1M
MT1X metallothionein 1X
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NQO1 NAD(P)H dehydrogenase, quinone 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
RCAN1 regulator of calcineurin 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
STC2 stanniocalcin 2
THBD thrombomodulin
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIB3 tribbles pseudokinase 3
TXNDC9 thioredoxin domain containing 9
UPK1B uroplakin 1B
ZNF131 zinc finger protein 131

decreased expression

Symbol Name
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CD200 CD200 molecule
CNN3 calponin 3, acidic
DMD dystrophin
FAM69A family with sequence similarity 69, member A
GJA1 gap junction protein, alpha 1, 43kDa
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA1A heat shock 70kDa protein 1A
IFI27 interferon, alpha-inducible protein 27
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LPAR6 lysophosphatidic acid receptor 6
MXRA7 matrix-remodelling associated 7
NOV nephroblastoma overexpressed
OLFM4 olfactomedin 4
OSBPL10 oxysterol binding protein-like 10
PDGFC platelet derived growth factor C
PDGFD platelet derived growth factor D
PEG10 paternally expressed 10
POSTN periostin, osteoblast specific factor
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
TFRC transferrin receptor
ZNF395 zinc finger protein 395
ZNF586 zinc finger protein 586
ZSCAN18 zinc finger and SCAN domain containing 18
Funding